Navigation Links
Shape of nanoparticles points the way toward more targeted drugs

LA JOLLA, Calif., June 10, 2013 Conventional treatments for diseases such as cancer can carry harmful side effectsand the primary reason is that such treatments are not targeted specifically to the cells of the body where they're needed. What if drugs for cancer, cardiovascular disease, and other diseases can be targeted specifically and only to cells that need the medicine, and leave normal tissues untouched?

A new study involving Sanford-Burnham Medical Research Institute's Erkki Ruoslahti, M.D., Ph.D., contributing to work by Samir Mitragotri, Ph.D., at the University of California, Santa Barbara, found that the shape of nanoparticles can enhance drug targeting. The study, published in Proceedings of the National Academy of Sciences, found that rod-shaped nanoparticlesor nanorodsas opposed to spherical nanoparticles, appear to adhere more effectively to the surface of endothelial cells that line the inside of blood vessels.

"While nanoparticle shape has been shown to impact cellular uptake, the latest study shows that specific tissues can be targeted by controlling the shape of nanoparticles. Keeping the material, volume, and the targeting antibody the same, a simple change in the shape of the nanoparticle enhances its ability to target specific tissues," said Mitragotri.

"The elongated particles are more effective," added Ruoslahti. "Presumably the reason is that if you have a spherical particle and it has binding sites on it, the curvature of the sphere allows only so many of those binding sites to interact with membrane receptors on the surface of a cell."

In contrast, the elongated nanorods have a larger surface area that is in contact with the surface of the endothelial cells. More of the antibodies that coat the nanorod can therefore bind receptors on the surface of endothelial cells, and that leads to more effective cell adhesion and more effective drug delivery.

Testing targeted nanoparticles

Mitragotri's lab tested the efficacy of rod-shaped nanoparticles in synthesized networks of channels called "synthetic microvascular networks," or SMNs, that mimic conditions inside blood vessels. The nanoparticles were also tested in vivo in animal models, and separately in mathematical models.

The researchers also found that nanorods targeted to lung tissue in mice accumulated at a rate that was two-fold over nanospheres engineered with the same targeting antibody. Also, enhanced targeting of nanorods was seen in endothelial cells in the brain, which has historically been a challenging organ to target with drugs.

Nanoparticles already used in some cancer drugs

Nanoparticles have been studied as vessels to carry drugs through the body. Once they are engineered with antibodies that bind to specific receptors on the surface of targeted cells, these nanoparticles also can, in principle, become highly specific to the disease they are designed to treat.

Ruoslahti, a pioneer in the field of cell adhesionhow cells bind to their surroundingshas developed small chain molecules called peptides that can be used to target drugs to tumors and atherosclerotic plaques.

Promising results

"Greater specific attachment exhibited by rod-shaped particles offers several advantages in the field of drug delivery, particularly in the delivery of drugs such as chemotherapeutics, which are highly toxic and necessitate the use of targeted approaches," the authors wrote in their paper.

The studies demonstrate that nanorods with a high aspect ratio attach more effectively to targeted cells compared with spherical nanoparticles. The findings hold promise for the development of novel targeted therapies with fewer harmful side effects.


Contact: Deborah Robison
Sanford-Burnham Medical Research Institute

Related medicine news :

1. Four Skechers Lawsuits Filed by Wright & Schulte LLC on Behalf of Consumers Who Suffered Serious Knee Injuries Allegedly Due to Dangerous Design of Skechers Shape-Ups
2. Skechers Lawsuit Filed by Wright & Schulte on Behalf of Virginia Man Who Suffered Serious Back Injuries Allegedly Due to Use of Defectively Designed Shape-Ups
3. Before You Sail Away for Summer, Dive Into Your Supply Chain Technology - Is it in Ship-shape or is it a Shipwreck?
4. Shape-shifting nanoparticles flip from sphere to net in response to tumor signal
5. Weight Loss Secrets
6. How “The Fat Loss Code” Helps People Gain A Healthy Life And Get In Shape - Health Review
7. Ten Skechers Lawsuits Filed by Wright & Schulte on Behalf of Consumers Who Sustained Severe Tendon Damage Allegedly Due to Wearing Skechers Shape-Ups
8. How To Get Ripped Fast
9. How “Adonis Golden Ratio” Helps Men Achieve Their Ideal Body Shape –
10. PolyU introduces International Design and Business Management Master Programme to Develop "T-Shaped" Professionals
11. Skechers Stress Fractures Lawsuit Filed on Behalf of Woman Who Suffered Six Stress Fractures Allegedly from Skechers Shape-Ups Toning Shoes, by Wright & Schulte LLC
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, I ... Bronx, N.Y. “I thought there had to be a convenient and comfortable way to ... The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. In ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care ... disease. The Periwinkle Pioneers, nominated by the public, will receive special recognition throughout ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... philanthropic seniors, is resulting in a way for homeless people to have a ... have launched a new initiative whereby they are repurposing plastic bags into sleeping ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in 2012, ... adult stem cell therapies to patients with chronic degenerative medical conditions. Now, the ... Registered Trademark (RTM). , Organizations are required to hold a registered trademark in ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic Software ... software creates an agreement between the practice owner and the patient that automatically ... notification, and projections. Click here to learn more. , ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Thanks to ... Dignity Health St. Mary,s Medical Center,s Sister Diane Grassilli ... breast imaging capabilities in San Francisco ... an anonymous friend, stepped forward with a gift of ... for Breast Digital Mammography with Tomosynthesis and Whole Breast ...
(Date:11/24/2015)... Colo. , Nov. 24, 2015  Array ... that its Chief Executive Officer, Ron Squarer ... Healthcare Conference in New York.  The public is ... webcast on the Array BioPharma website.Event:Piper Jaffray Annual ... , Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time ...
(Date:11/24/2015)... HOUSTON, TX and VANCOUVER, Nov. 24, 2015 /PRNewswire/ ... EPI; NASDAQ: EPIX ) announced today that the ... clinical study of EPI-506 as a treatment for metastatic ... States and Canada.  --> ... --> In the Phase 1/2 clinical trial, ...
Breaking Medicine Technology: