Navigation Links
Shape matters: The corkscrew twist of H. pylori enables it to 'set up shop' in the stomach
Date:5/27/2010

SEATTLE The bacterium Helicobacter pylori, which lives in the human stomach and is associated with ulcers and gastric cancer, is shaped like a corkscrew, or helix. For years researchers have hypothesized that the bacterium's twisty shape is what enables it to survive and thrive within the stomach's acid-drenched environment, but until now they have had no proof.

For the first time, researchers at Fred Hutchinson Cancer Research Center have found that, at least when it comes to H. pylori's ability to colonize the stomach, shape indeed matters. Microbiologist Nina Salama, Ph.D., and colleagues report their findings May 28 in Cell.

Salama and colleagues are the first to demonstrate that the bug's helical shape helps it set up shop in the protective gelatin-like mucus that coats the stomach. Such bacterial colonization present in up to half of the world's population causes chronic inflammation that is linked to a variety of stomach disorders, from chronic gastritis and duodenitis to ulcers and cancer.

"By understanding how the bug colonizes the stomach, we can think about targeting therapy to prevent infection in the first place," said Salama, the paper's corresponding author and an associate member of the Human Biology Division at the Hutchinson Center. The paper's first author, Laura K. Sycuro, Ph.D., conducted this work while a student in the University of Washington/Fred Hutchinson Cancer Research Center Molecular and Cellular Biology graduate program. She is now a postdoctoral research associate in the Hutchinson Center's Clinical Research Division.

Specifically, the researchers discovered a group of four proteins that are responsible for generating H. pylori's characteristic curvature. Using a mouse model, they found that laboratory-engineered mutant strains of H. pylori that are deficient in these proteins fail to twist properly and, consequently, are unable to colonize the stomach. '/>"/>

Contact: Kristen Lidke Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A Must-Hear Free Summer Seminar - Dr. Sherrill Sellman Reveals "Secrets for Getting in 'Summer Shape' with Ancient Herbs"
2. Healthy Diet From Down Under To Help Brits Shape Up For Summer
3. Innovative Patent-pending Shapewear Technology Introduced for Jeans.
4. Study Published by Circulation Heart Failure Reinforces Science Behind Shape-HF Cardiopulmonary Exercise Testing Device
5. The Fresh Diet Dances With The Stars Keeping the Cast in Shape and on Its Toes
6. The Fresh Diet Dances With The Stars Keeping the Cast in Shape and on Its Toes
7. Study Results Validate Shape-HF as Simplified, Portable Cardiopulmonary Exercise Testing System
8. UW Symposium: How Disease, Therapy, Drugs and Meditation Reshape the Brain
9. The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape
10. Doctor Joseph Racanelli is Helping Christina Get Back Her Shape After Brutal Attack
11. Apex Heart Care, First Arizona Clinic to Install Shape-HF; New Medical Device Measures Patient Physiology to Define Shortness of Breath
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Massachusetts (PRWEB) July 28, 2014 ... Summit Provider Exchange technology solution in ... integration efforts and support collaboration with their New ... bed acute-care medical center located in New Jersey, ... seasonal visitors with a variety of inpatient and ...
(Date:7/28/2014)... Maureen Salamon ... News) -- Infants and children who are at risk ... be vaccinated against the infection, according to updated recommendations ... And routine vaccinations for the potentially deadly ... American Academy of Pediatrics says. In its first ...
(Date:7/28/2014)... News) -- British researchers report that an alternative to ... In their experiments, the scientists found that clasping ... person to the other than what is known as ... might suffice as a cultural substitute for the firm ... the August issue of the American Journal of ...
(Date:7/28/2014)... HealthDay Reporter MONDAY, July ... heart rhythm irregularities are more likely to get a pacemaker ... fact, the study of more than 16,000 people found that ... to get a pacemaker than those without the memory-robbing condition. ... folks with dementia are so much more likely to be ...
(Date:7/28/2014)... 28, 2014 SIMpalm helped its ... App is available on iTunes for download . Experience ... Audio Chef allows you to listen and cook along with ... way: simply get out the ingredients and equipment, press play, ... or prepare ingredients ahead of time, just relax and cook ...
Breaking Medicine News(10 mins):Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 2Health News:Cape Regional Medical Center Chooses Summit Provider Exchange to Connect With NJSHINE and Physician Offices 3Health News:Doctors Urge Meningitis Shots for Vulnerable Infants, Children 2Health News:Doctors Urge Meningitis Shots for Vulnerable Infants, Children 3Health News:'Fist Bump' May Beat Handshake for Cleanliness 2Health News:'Fist Bump' May Beat Handshake for Cleanliness 3Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 2Health News:Pacemakers Common for Those With Dementia and Irregular Heartbeats 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4
... in post-menopausal women after they stopped taking combined hormone ... will be reported in the March 5 edition of ... Rowan T. Chlebowski, M.D., Ph.D., a Los Angeles Biomedical ... the study. , This latest study reinforces the original ...
... N.C., March 4 DARA BioSciences(TM),(Nasdaq: DARA ... Drutz, MD to the,Board of Directors. Dr. Drutz ... serve on the Company,s Compensation Committee as well ... effective February,26, 2008., Richard Franco, Sr., DARA,s ...
... ISTA Pharmaceuticals,Inc. (Nasdaq: ISTA ), today announced it ... 2008, after the U.S. markets close. ISTA will,host a ... and provide a commercial and pipeline update at 5:00 ... live conference call, U.S. and Canadian participants may,dial 866-831-6270; ...
... Initiative points to continued need for mammograms , , TUESDAY, ... cancer lingers after a woman stops taking combination hormone replacement ... in the March 5 issue of the Journal of ... the landmark Women,s Health Initiative (WHI). That trial was halted ...
... 2,500 researchers and professionals in the area of biomolecular science ... Conference & Exhibition of the Society for Biomolecular Sciences (SBS) ... advances in biotechnology, challenges and automation solutions in the field. ... years meeting include: , New Methods ...
... March 4 Perrigo Company,(Nasdaq: PRGO ; ... 20 mg,Omeprazole delayed released tablets to its retail ... same dose as Prilosec OTC(R). Under terms,of an ... is,the exclusive marketer and distributor for the store ...
Cached Medicine News:Health News:LA BioMed researcher says 'unexpected' increase in cancer risk found 2Health News:DARA BioSciences, Inc. Announces Appointment of Dr. David J. Drutz to Board 2Health News:Raised Breast Cancer Risk Persists After Combo HRT Stopped 2Health News:Raised Breast Cancer Risk Persists After Combo HRT Stopped 3Health News:Specialists in drug discovery and development convene 2Health News:Perrigo Company Announces Initial Shipments of Store Brand Omeprazole Tablets 2Health News:Perrigo Company Announces Initial Shipments of Store Brand Omeprazole Tablets 3
(Date:7/28/2014)... , July 28, 2014 /PRNewswire-iReach/ -- June 28 th ... laboratory which has developed the AMAS cancer test, is making ... Chicago.  To date, the test, which is a serum-based in ... is emerging as a significant tool in the fight against ... With an estimated 17 million cancer survivors in ...
(Date:7/28/2014)...  Serco Inc., a provider of professional, technology, ... awarded a re-compete contract to support the Navy ... Medical Systems.  Serco will provide deployable medical systems ... healthcare to meet warfighter and humanitarian requirements in ... five year contract has a one-year base period ...
(Date:7/28/2014)... , July 28, 2014 Southern ... Tipton , Ph.D., President and CEO of Southern ... Controlled Release Society (CRS) for the 2014-2015 term.  ... meeting on July 12 in Chicago ... countries.  The Controlled Release Society ...
Breaking Medicine Technology:Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2Serco Awarded $22.7 Million Contract to Support Deployable Medical Systems 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3
... a leader in the pharmaceutical treatment of breathing-control disorders, ... Thomas J. Dietz, Ph.D., as the company,s chairman.  Dr. ... a diversified financial-holdings and services company.   ... and a director of Pacific Growth Equities, LLC, a ...
... YORK, Oct. 26, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0158569/Medical-Imaging-Markets-Contrast-Agents.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging The ... are continuing to grow in significance as ...
Cached Medicine Technology:Thomas Dietz, Ph.D., Elected Chairman of Galleon Pharmaceuticals 2Medical Imaging Markets: Contrast Agents 2Medical Imaging Markets: Contrast Agents 3Medical Imaging Markets: Contrast Agents 4Medical Imaging Markets: Contrast Agents 5Medical Imaging Markets: Contrast Agents 6
The DSL-10-3000 ACTIVE Ferritin Enzyme-Linked Immunosorbent (ELISA) Kit provides materials for the quantitative measurement of ferritin in serum....
... Bio-Rad isotopic anemia ... and minimal ,pipetting steps ... information about the processes ... and the benefit to ...
... Bio-Rad isotopic anemia ... and minimal ,pipetting steps ... information about the processes ... and the benefit to ...
... Bio-Rad isotopic anemia assays ... minimal ,pipetting steps for ... about the processes ,involved ... the benefit to your ...
Medicine Products: