Navigation Links
Shape matters: The corkscrew twist of H. pylori enables it to 'set up shop' in the stomach
Date:5/27/2010

SEATTLE The bacterium Helicobacter pylori, which lives in the human stomach and is associated with ulcers and gastric cancer, is shaped like a corkscrew, or helix. For years researchers have hypothesized that the bacterium's twisty shape is what enables it to survive and thrive within the stomach's acid-drenched environment, but until now they have had no proof.

For the first time, researchers at Fred Hutchinson Cancer Research Center have found that, at least when it comes to H. pylori's ability to colonize the stomach, shape indeed matters. Microbiologist Nina Salama, Ph.D., and colleagues report their findings May 28 in Cell.

Salama and colleagues are the first to demonstrate that the bug's helical shape helps it set up shop in the protective gelatin-like mucus that coats the stomach. Such bacterial colonization present in up to half of the world's population causes chronic inflammation that is linked to a variety of stomach disorders, from chronic gastritis and duodenitis to ulcers and cancer.

"By understanding how the bug colonizes the stomach, we can think about targeting therapy to prevent infection in the first place," said Salama, the paper's corresponding author and an associate member of the Human Biology Division at the Hutchinson Center. The paper's first author, Laura K. Sycuro, Ph.D., conducted this work while a student in the University of Washington/Fred Hutchinson Cancer Research Center Molecular and Cellular Biology graduate program. She is now a postdoctoral research associate in the Hutchinson Center's Clinical Research Division.

Specifically, the researchers discovered a group of four proteins that are responsible for generating H. pylori's characteristic curvature. Using a mouse model, they found that laboratory-engineered mutant strains of H. pylori that are deficient in these proteins fail to twist properly and, consequently, are unable to colonize the stomach. '/>"/>

Contact: Kristen Lidke Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A Must-Hear Free Summer Seminar - Dr. Sherrill Sellman Reveals "Secrets for Getting in 'Summer Shape' with Ancient Herbs"
2. Healthy Diet From Down Under To Help Brits Shape Up For Summer
3. Innovative Patent-pending Shapewear Technology Introduced for Jeans.
4. Study Published by Circulation Heart Failure Reinforces Science Behind Shape-HF Cardiopulmonary Exercise Testing Device
5. The Fresh Diet Dances With The Stars Keeping the Cast in Shape and on Its Toes
6. The Fresh Diet Dances With The Stars Keeping the Cast in Shape and on Its Toes
7. Study Results Validate Shape-HF as Simplified, Portable Cardiopulmonary Exercise Testing System
8. UW Symposium: How Disease, Therapy, Drugs and Meditation Reshape the Brain
9. The VA Maryland Health Care System Offers Tips for Senior Citizens and Older Adults to Spring into Shape
10. Doctor Joseph Racanelli is Helping Christina Get Back Her Shape After Brutal Attack
11. Apex Heart Care, First Arizona Clinic to Install Shape-HF; New Medical Device Measures Patient Physiology to Define Shortness of Breath
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... 06, 2015 Dr. Amy Reed, who together ... ban on the use of power morcellators ( http://www.morcellatorlawsuit2015.com ) ... cancer that prompted the launch of their public health campaign. ... that the 41-year-old mother of six had recently undergone surgery ... her spine. Dr. Reed had been in remission for about ...
(Date:3/6/2015)... Ticket Down is a reliable source for authentic ... Clara, California. This state-of-the-art stadium opened on July 17, ... events. , The “Kick the Dust Up Tour” featuring country ... the west coast and Levi’s Stadium. The show at the ... August 29 and fans of the award-winning artist will be ...
(Date:3/6/2015)... 06, 2015 Follow us on ... most common forms of cancer and is the leading ... be screened through various techniques and tools, including mammography, ... the gold standard technique in breast cancer screening, driven ... taken for the procedure, required expertise to carry out ...
(Date:3/6/2015)... Ticket Down is a reputable source for authentic ... their customer appreciation discount code ED-SHEERAN-2015 for added savings. , ... he began his career in the music industry 10 years ... Ed Sheeran has become a household name. , It ... is having the time of his life and his audiences ...
(Date:3/6/2015)... Further solidifying their position as a ... today that the company has earned Inavero’s Best of ... Staffing Talent Award five years in a row. Presented ... Diamond winners are proven industry leaders in service quality ... individuals they have helped find temporary and permanent jobs. ...
Breaking Medicine News(10 mins):Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 2Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 3Health News:Power Morcellator News: Bernstein Liebhard LLP Comments on Report that Physician Working to Ban Uterine Morcellation Has Cancer Recurrence 4Health News:Cheap Luke Bryan Tickets at Levi's® Stadium in Santa Clara, CA: Ticket Down Slashes Ticket Prices on Luke Bryan Concert Tickets in Santa Clara at the New Levi's® Stadium 2Health News:Cheap Luke Bryan Tickets at Levi's® Stadium in Santa Clara, CA: Ticket Down Slashes Ticket Prices on Luke Bryan Concert Tickets in Santa Clara at the New Levi's® Stadium 3Health News:Rising Popularity of 3D Mammography Drives the Global Mammography Equipment Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Rising Popularity of 3D Mammography Drives the Global Mammography Equipment Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Ed Sheeran Tickets in Indianapolis, Austin, Albany, St. Louis, London, Des Moines, Salt Lake City, Saskatoon, Regina and Denver/Morrison Now On Sale at Ticket Down 2Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 2Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 3
... point to lymph node involvement, study suggests , , WEDNESDAY, ... the area surrounding cancerous tumors in the breast are ... not the cancer spreads to the lymph nodes, new ... tumor-suppressing p53 gene in the stroma -- the region ...
... to Serve on Corporate Boards, WASHINGTON, Dec. 19 ... a need exists,for highly qualified, informed candidates to serve ... board seat. In response to this need and also,to ... Lynn Shapiro,Snyder, Esq. and Robert Reif, Esq., senior attorneys ...
... Bay Area Start-up takes the first step in offering ... Wednesday, December 19,Alijor.com announced its plan to expand its ... San Francisco Bay Area during,the summer of 2007, and ... New York City. The company hosts a website where ...
... impact on behavior, studies show , , WEDNESDAY, Dec. 19 (HealthDay ... trillion cells, looking for perhaps only one or a handful ... of new studies says. , The research, conducted with rodents ... , could rewrite the textbooks on just how important individual ...
... The holidays are a,time when many of us are ... in this community who are hoping to receive the most,important ... This past year, more than 1,000 people in our ... of many donors,and their families. But even more continue to ...
... complete the application process were offered,coverage, WASHINGTON, ... health insurance market released today by America,s,Health Insurance ... more,accessible and affordable than is widely known. The ... were offered coverage, and that,consumers have access to ...
Cached Medicine News:Health News:Area Around Breast Tumor May Predict Cancer's Spread 2Health News:Area Around Breast Tumor May Predict Cancer's Spread 3Health News:Roadmap Released for Senior Executives Who Want to Reach the 'Pinnacle' 2Health News:Roadmap Released for Senior Executives Who Want to Reach the 'Pinnacle' 3Health News:Brain Cells More Powerful Than You Think 2Health News:Brain Cells More Powerful Than You Think 3Health News:Brain Cells More Powerful Than You Think 4Health News:Giving the Gift of Life During the Holidays 2Health News:New AHIP Survey Finds Individual Health Care Coverage Accessible and Affordable 2Health News:New AHIP Survey Finds Individual Health Care Coverage Accessible and Affordable 3
(Date:3/5/2015)... PharmaTech (Cayman) Inc. (NYSE: WX ), a ... the pharmaceutical, biotechnology, and medical device industries, with operations ... financial results for the fourth quarter and full year ... Net Revenues Increased 21.3% Year Over Year to $190.6 ... Year Over Year to $140.5 Million , Manufacturing ...
(Date:3/5/2015)... and TÜBINGEN, Germany , March ... Gates Foundation and CureVac today announced that the ... million (€46 million) in CureVac, a leading clinical-stage ... part of the agreement, the foundation will also ... prophylactic vaccines based on CureVac,s proprietary messenger RNA ...
(Date:3/5/2015)... N.J. , March 5, 2015 CANTEL MEDICAL ... for its second quarter ended January 31, 2015 on Thursday, ... call to discuss the results at 11:00 AM ET. ... 407-8033 approximately 5 to 10 minutes before the beginning of ... replay of the call will be available from Thursday, March ...
Breaking Medicine Technology:WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 2WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 3WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 4WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 5WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 6WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 7WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 8WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 9WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 10WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 11WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 12WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 13WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 14WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 15WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 16WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 17WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 18WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 19WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 20WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 21WuXi PharmaTech Announces Fourth-Quarter and Full-Year 2014 Results 22The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 2The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 3The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology 4Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Second Quarter Ended January 31, 2015 2
... WALTHAM, Mass., Jan. 4, 2011 Syndax Pharmaceuticals, Inc., ... Horobin, M.D., the company,s president and CEO, will present ... 2011 at 10:00 a.m. PT at the Parc 55 ... include the recently reported results from a randomized phase ...
... Jan. 4, 2011 STAAR Surgical Company (Nasdaq: ... and marketer of minimally invasive ophthalmic products, today ... ICL implants in patients has exceeded 200,000.  Since ... used in refractive eye surgery as an alternative ...
Cached Medicine Technology:STAAR Surgical's Visian® ICL Surpasses 200,000 Implants 2STAAR Surgical's Visian® ICL Surpasses 200,000 Implants 3
For the quantitative determination of direct & total bilirubin in serum. Modified Malloy-Evelyn Diazotization Method. Endpoint Reaction Product measured at 540 nm. Linearity: 20 mg/dl...
... Spectrophotometers are simple, reliable ... use in many types ... clinical, industrial and environmental ... vial holders, Windows based ...
Spectra 5000 is one of the most versatile analytical devices used in conventional laboratories which can work in the ultravoilet and visible range from 200 to 1000 nm for quantitative and qualitative...
... 400 Series Spectrophotometer ... approach to UV-VIS instrumentation. ... are incorporated into a ... in features and performance ...
Medicine Products: