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Severe heart defect likely caused by genetic factors
Date:10/10/2007

pointed to the role of certain genes (TBX5 and IRX1) in the formation of defective heart chambers with distinct shapes, functionality and molecular structure. Based on analysis of how these genes function, scientists hypothesize that HLHS may result from a primary defect in the growth of muscle tissue during the hearts development.

Currently there are no experimental models to clarify the relative contributions of these two hypotheses to the development of HLHS, Dr. Hinton said. An important step forward in this research will be to understand the degree to which these hypothetical causes actually contribute to the condition.


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Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

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