Navigation Links
Severe heart defect likely caused by genetic factors
Date:10/10/2007

ve with HLHS or an associated heart defect. Of 193 blood relatives evaluated between the ages of 3 days and 74 years, 21.4 percent had HLHS or associated heart defects. In families where one child already had HLHS, the risk of HLHS recurring in a sibling was 8 percent while the risk of a sibling having an HLHS-associated cardiovascular defect was 22 percent. In families where a child and one parent had HLHS, the recurrence risk increased dramatically to 21 percent for recurring HLHS and 25 percent for an associated defect. All participants were evaluated using echocardiography to determine specific phenotype, or the visible heart characteristics and defects found among the different family test groups. During those examinations researchers diagnosed 12 new cases of associated defects among relatives of HLHS patients.

Researchers recommend further studies to pinpoint specific genes responsible for the condition. Finding the genetic basis of HLHS could have significant implications for treating children with the disease, said D. Woodrow Benson, M.D., Ph.D., director of Cardiovascular Genetics at Cincinnati Childrens and the studys senior author. This includes identifying possible interventions during fetal life (such as catheter-based procedures), the most appropriate postoperative drug therapies for individual children and determining the potential risks for failure of the right ventricle.

By using family based linkage analysis, where specific genetic traits are mapped, it should be possible to identify the genes that cause the disease, Dr. Benson said. Once we know what genes are involved we can study how the disease developments, which may lead to new treatment approaches.

Earlier studies in animals indicate HLHS may develop because of embryonic alterations in blood flow, such as a premature narrowing of the aortic valve and foramen ovale (which in the fetal heart allows blood to enter the left atrium from the right). Other studies have
'/>"/>

Contact: Nick Miller
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Patients With Severe Hemophilia At Risk Of Developing Osteoporosis
3. Severe stress weakens immunity
4. Severe Acute respiratory Syndrome (SARS)
5. WHO Travel Advice to prevent spread of "Severe Acute Respiratory Syndrome (SARS)
6. Traffic pollution linked to severe asthma attacks
7. Severe sleep apnea can cause liver problems
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. Strong Magnetic Stimulation Can Help Treating Severe Depression
10. Patients Suffering From Severe Mental Diseases Are At Risk Of Being Crime Victims
11. Acute Toxicity Of Nano-Scale Zinc Powder: Severe Renal Damage And Anemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... Mike Day, a former ... will compete in the Ironman World Championships in Kona on October 10th. , Mike ... Traumatic Brain Injury (TBI) through combat and the cutting-edge treatments that restore their quality ...
(Date:9/4/2015)... OR (PRWEB) , ... September 04, 2015 , ... ... markets a line of personal humidifying medical devices, announced its only mission and ... explains Bio-Logic Aqua® Research Founder Sharon Kleyne, body water evaporation is becoming dangerously ...
(Date:9/4/2015)... ... 04, 2015 , ... The conference program for the upcoming ... 9-10, 2015 at the Diplomat Resort & Spa has been announced and is ... at the top of their field and will be presenting sessions such as ...
(Date:9/4/2015)... ... 2015 , ... ECC announces the site selection and commencement ... with intellectual, developmental and acquired disabilities. The first community, named Luna Azul, will ... homes. In this community, adults will live safely and permanently in homes owned ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... in South Glastonbury, Connecticut, has been selected for the Residential Award of Merit ... efficiency and resiliency measures. Chosen from a highly competitive field of submissions, the ...
Breaking Medicine News(10 mins):Health News:Navy SEAL Shot 27 Times Competes in Ironman World Championship in Kona to Raise Money for Veteran's Suffering from TBI and PTSD 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 3Health News:Integrative Healthcare Symposium Focus On: The Microbiome Conference Program Announced 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4Health News:South Glastonbury Home Selected for Award by Connecticut Green Building Council 2
... (NYSE Amex: FHC ) today announced that it ... results for the second quarter and first half of FY2009 ... 2009. The Company expects to report its second quarter ... day. Shareholders and other interested parties may participate in the ...
... COSTA MESA, Calif., May 1 Oxygen Biotherapeutics, Inc. ... has filed a Cosmetic Product Ingredient Statement (CPIS) with ... product. Oxycyte is the company,s perfluorocarbon (PFC) therapeutic ... sign that we are a big step closer to ...
... after a fall, sudden twist or blow to the ankle joint. ... experience chronic ankle pain, even after being treated for their initial ... 2009 issue of the Journal of the American Academy of ... ankle can be a possible cause for this chronic pain. ...
... Guidelines at the Point of Care-TAMPA, Fla., May ... of drug information applications and clinical information solutions, ... is now providing physicians with the latest treatment ... by the Centers for Disease Control and Prevention ...
... and active Mediterranean lifestyle are curePALM BAY, Fla., May ... likely we are to maintain a healthy diet -- ... than that eaten in the Mediterranean?In his new book, ... published by iUniverse ), Ray Adamcik M.D., ...
... NUTLEY, N.J., May 1 /PRNewswire/ -- ... contributions to industry in New Jersey at the ... Honored were Nancy Shore DiLella, J.D., senior counsel ... the leading hepatitis C treatment, Pegasys(R) (peginterferon alfa-2a); ...
Cached Medicine News:Health News:The Female Health Company Schedules Second Quarter Conference Call for May 8, 2009 2Health News:Oxygen Biotherapeutics, Inc. Files Cosmetic Product Ingredient Statement for new Oxycyte-based Cosmetic Gel 2Health News:Oxygen Biotherapeutics, Inc. Files Cosmetic Product Ingredient Statement for new Oxycyte-based Cosmetic Gel 3Health News:Chronic ankle pain may be more than just a sprain 2Health News:EMPOWERx E-Prescribing Solution Provides Latest Treatment Guidelines for 2008-2009 H1N1 Influenza Virus 2Health News:'The Globe's Best Diet: The Metabolic Syndrome Cure' 2Health News:Roche Women Honored as 2009 TWIN Awardees 2Health News:Roche Women Honored as 2009 TWIN Awardees 3Health News:Roche Women Honored as 2009 TWIN Awardees 4Health News:Roche Women Honored as 2009 TWIN Awardees 5
(Date:9/4/2015)... Texas , Sept. 4, 2015  Luminex Corporation ... present at the Morgan Stanley Global Healthcare Conference to ... Grand Hyatt Hotel in New York City ... at 11:40 a.m. Eastern time on Friday, September 18, ... accessed at Luminex Corporation,s website at http://www.luminexcorp.com . ...
(Date:9/4/2015)... 4, 2015 According to a ... Plateletpheresis, Erythrocytapheresis, Leukapheresis, and Photopheresis) by Procedure (Therapeutic Apheresis, ... - Global Forecast to 2020", published by MarketsandMarkets, the ... Billion by 2020, growing at a CAGR of 11.2% ... Browse 139 Tables and 45 F ...
(Date:9/4/2015)... Oramed Pharmaceuticals Inc. (NASDAQ: ... focused on the development of oral drug delivery systems, ... upcoming Rodman & Renshaw 17 th Annual Global ... New York City .  Dr. Michael ... overview on September 9, 2015. Presentation ...
Breaking Medicine Technology:Luminex Corporation To Present At The Morgan Stanley Global Healthcare Conference 2Apheresis Market Worth 2.5 Billion USD by 2020 2Apheresis Market Worth 2.5 Billion USD by 2020 3Apheresis Market Worth 2.5 Billion USD by 2020 4Apheresis Market Worth 2.5 Billion USD by 2020 5Oramed to Present at the Rodman & Renshaw Global Investment Conference 2Oramed to Present at the Rodman & Renshaw Global Investment Conference 3
... 2011 Par Pharmaceutical Companies, Inc. (NYSE: PRX ... EST on Friday, January 6, 2012 at the Millennium Hotel, ... Executive Officer, Patrick G. LePore, and other members of the ... growth strategy, current products and pipelines, and business outlook to ...
... Calif., Dec. 5, 2011  Beyond Lucid Technologies, Inc., ... disaster management, and First Response industries, today announced ... the mHealth Summit, and the publication of a ... connect ambulances with hospitals via telemedicine. ...
Cached Medicine Technology:Beyond Lucid Technologies Advances Telemedicine for EMS Providers 2Beyond Lucid Technologies Advances Telemedicine for EMS Providers 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: