Navigation Links
Severe heart attack damage limited by hydrogen sulfide
Date:9/19/2007

BIRMINGHAM, Ala. Administering hydrogen sulfide (H2S) directly into the heart during a simulated heart attack significantly reduces the tissue and cell damage often seen in oxygen-starved organs, according to a new study from researchers at the University of Alabama at Birmingham.

H2S boosts post-heart-attack function by helping to minimize reperfusion injury, an unwanted side effect of restoring blood flow swiftly to hearts suffering from low oxygen, the study authors said.

In testing on mice, the H2S injection led to a 72 percent reduction in the amount of severe heart-tissue death after restoring normal oxygen and blood flow to mice hearts. The 72 percent reduction compares to a much larger average amount of tissue death in un-treated mice hearts after the same 30 minutes of oxygen deprivation.

Findings on the protective qualities of H2S have broad implications for improving human survival after cardiac arrest, heart transplant and trauma in general, said David Kraus, Ph.D., a UAB associate professor in the Departments of Environmental Health Sciences and Biology and co-author on the new study.

One of the most damaging biological stresses on the heart and other organs from trauma or transplantation is the rapid change in oxygen levels, Kraus said. First theres a drop, which elicits a dramatic cellular adjustment to survive low oxygen, and then a rapid rise caused by resuscitation.

H2S as an internal bodily signal appears to serve as an important protective mechanism during the stress of low oxygen availability, he said.

The study was published Sept. 18 in the online Early Edition of the journal Proceedings of the National Academy of Sciences. The UAB researchers worked with a team led by David Lefer, Ph.D. from the Albert Einstein College of Medicine in Bronx, N.Y.

The tests were done by injecting H2S directly into the hearts of mice who had been anesthetized for surgery, and whose left ventricular artery had been clamped for 30 minutes to simulate a heart attack.

In addition to a decrease in heart-tissue death, H2S-treated mice hearts showed a 35 percent drop in blood-protein levels that signal myocardial damage, and a 26 percent drop in heart-tissue markers of inflammation when compared to un-treated mice hearts.

Furthermore, by isolating mitochondria from the H2S-treated mice, the authors confirmed that heart-cell functional integrity had been preserved. Recent reports from other researchers demonstrate that inhaled H2S can induce a fully reversible suspended animation state in animals.

Kraus said it follows that H2S could be used to place organs into suspended animation before surgery or during medical transport until normal oxygen and blood flow is restored. Also, by augmenting internal H2S production in the body, perhaps through diet, people may reduce their risks of cardiovascular disease, chronic oxidative cell damage and other illnesses, Kraus said.

H2S is normally considered a toxic, flammable gas that is responsible for the foul odor of rotten eggs. But in the UAB study it was carefully formulated into a low concentration saline-type solution.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Patients With Severe Hemophilia At Risk Of Developing Osteoporosis
3. Severe stress weakens immunity
4. Severe Acute respiratory Syndrome (SARS)
5. WHO Travel Advice to prevent spread of "Severe Acute Respiratory Syndrome (SARS)
6. Traffic pollution linked to severe asthma attacks
7. Severe sleep apnea can cause liver problems
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. Strong Magnetic Stimulation Can Help Treating Severe Depression
10. Patients Suffering From Severe Mental Diseases Are At Risk Of Being Crime Victims
11. Acute Toxicity Of Nano-Scale Zinc Powder: Severe Renal Damage And Anemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, ... Brake Technology (ABT), an innovative braking system that allows skaters of all levels ... one of the biggest concerns of beginner and intermediate skaters – learning how ...
(Date:1/18/2017)... ... , ... Floundering on New Year’s resolutions? Need an excuse to get back ... The U.S. Apple Association agrees and recommends starting each day with apples, a ... heart disease. , The U.S. Apple Association – which represents apple growers and producers ...
(Date:1/17/2017)... ... ... Anesthesia Progress – Everyone wants less pain during dental surgery, but ... patient. Dentists have several general anesthesia alternatives and finding the right option can result ... College in Tokyo, Japan wanted to find out which anesthetic was the better choice ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... of difference. Eden Activewear is a stand-out company for several differences from other ... and only manufacture on demand, this is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, to ... Carol Francis re-releases powerfully uplifting interview with medical expert and prolific author, Dr. ... and pass through tough times, Dr. Bernie Siegel energizes listeners to live life ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017   Synthetic Biologics, Inc. (NYSE ... designed to preserve the microbiome to protect and ... to initiate a Phase 2b/3 adaptive pivotal trial ... lactone designed to reduce methane production by certain ... to treat the underlying cause of irritable bowel ...
(Date:1/18/2017)...  Aprima Medical Software, a leading provider of ... and revenue cycle management (RCM) solutions for medical ... reseller Healthcare Data Solutions (HDS) of Coral Cables, ... assume full support for HDS,s customers, which include ... 15 states. Financial terms were not disclosed. ...
(Date:1/18/2017)... Jan. 18, 2017   Spotlight Innovation Inc. ... Therapeutics plans, in the second quarter of 2017, ... roll-on intended to provide relief from chronic pain, ... analgesics. It was developed under a licensing agreement ... products derived from snake venom. Additionally, Caretta Therapeutics ...
Breaking Medicine Technology: