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Severe asymptomatic heart disease may accompany narrowing in leg arteries
Date:12/1/2009

CHICAGO Results of a randomized, controlled clinical trial presented today at the annual meeting of the Radiological Society of North America (RSNA) reveal that one in five patients with narrowing or blockage in arteries that supply blood to the legs and other parts of the body also have significant but silent coronary artery disease.

Peripheral arterial disease (PAD) occurs when plaque, a combination of fat, cholesterol and other substances, builds up in the arteries, limiting the flow of oxygen-rich blood throughout the body. PAD usually affects arteries that carry blood to the legs, causing poor circulation, discomfort and pain. More than eight million Americans have PAD, according to the American Heart Association.

According to the National Heart, Lung and Blood Institute, coronary artery disease is the most common type of heart disease and the leading cause of death in the U.S.

"PAD patients, including those experiencing no symptoms of heart disease, are known to be at high risk for cardiovascular events such as a heart attack or stroke," said Rozemarijn Vliegenthart Proenca, M.D., Ph.D., radiology resident at the University Medical Center Groningen in the Netherlands. "The purpose of our clinical trial was to investigate whether noninvasive imaging of the heart and subsequent treatment of PAD patients result in a decrease in cardiac events compared to standard care."

In the clinical trial, a total of 231 PAD patients from four participating hospitals in the Netherlands were divided into one of two groups: one in which 108 patients received standard careconsisting of lifestyle changes and medicationfor their condition, and a second group in which 115 patients underwent cardiac imaging of the heart in addition to standard care.

"With new, noninvasive cardiac imaging techniques, asymptomatic coronary atherosclerosis can be readily detected and treated," Dr. Vliegenthart Proenca said.

Among the 115 pat
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Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

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