Navigation Links
Severe Sepsis Can Harm the Immune System

TUESDAY, Dec. 20 (HealthDay News) -- Severe sepsis can impair the immune system, a new study says.

Sepsis causes more than 225,000 deaths annually in the United States, the researchers said. "Developing new therapies for sepsis has been particularly challenging, with more than 25 unsuccessful drug trials," Jonathan S. Boomer, of the Washington University School of Medicine, St. Louis, and colleagues wrote as background information in the study. "Characterized by an initial intense inflammatory response or 'cytokine storm,' patients with sepsis may present with fever, shock, altered mental status, and organ dysfunction," they said.

"Whether this hyperinflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting," the researchers noted.

Sepsis is a severe, systemic bacterial infection occurring in the body's blood system or tissues. It can be life-threatening, and patients require rapid treatment with intravenous antibiotics.

For the new study, researchers analyzed lung and spleen tissue from 40 intensive care unit patients, average age 72, who died with active severe sepsis and compared them to spleen and lung samples from a control group of 49 people, average age 53, who died without sepsis.

The median (midpoint) number of days in the ICU for patients with sepsis was 8, and the median duration of sepsis was 4 days.

Findings from biochemical tests and cell and tissue analyses for patients who died of sepsis were consistent with immune suppression, compared to the patients who did not have sepsis when they died.

The study appears Dec. 21 in the Journal of the American Medical Association.

With therapies improving, patients are more likely to survive sepsis, the researchers suggested, but may still have impaired immune systems, leaving them more susceptible to infections from organisms that wouldn't affect healthier people.

"The present study has a number of important therapeutic implications. Most investigative agents in sepsis have been directed at blocking inflammation and immune activation. Although such therapies may be successful if applied early, they may be harmful if applied later in the immuno-suppressive phase," the researchers wrote in a journal news release.

"An important part of implementing more targeted therapies will be to accurately determine the immune status of individual patients during their disease," the researchers concluded.

More information

The U.S. National Institute of General Medical Sciences has more about sepsis.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Dec. 16, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
2. Severe sleep apnea decreases frequency of nightmare recall
3. Severe Sleep Apnea Has Silver Lining
4. H1N1 learnings: Risk factors for severe outcomes among patients admitted to hospital with H1N1
5. Obesity -- mild or severe -- raises kidney stone risk
6. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
7. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
8. Severe Injuries From ATV Accidents on the Rise
9. CEIT-IK4 designs tool for operations on people with severe or profound auditory loss
10. Georgia Dentist Uncovers Obscure Law That Helps Dental Patients With Severe Anxiety
11. Stem Cells Might One Day Treat Severe Asthma
Post Your Comments:
Related Image:
Severe Sepsis Can Harm the Immune System
(Date:10/13/2017)... ... 13, 2017 , ... Lori R. Somekh, founder of the Law Office ... of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our office ... forum to network with elder law attorneys nationwide,” said Somekh. , ElderCounsel ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
Breaking Medicine Technology: