Navigation Links
Severe COPD may lead to cognitive impairment
Date:7/7/2009

Severe chronic obstructive pulmonary disease (COPD) is associated with lower cognitive function in older adults, according to research from Mount Sinai School of Medicine. Researchers compared cognitive performance in over 4,150 adults with and without COPD and found that individuals with severe COPD had significantly lower cognitive function than those without, even after controlling for confounding factors such as comorbidities.

The results were published in the July 15 issue of the American Journal of Respiratory and Critical Care Medicine.

"Our findings should raise awareness that adults with severe COPD are at greater risk for developing cognitive impairment, which may make managing their COPD more challenging, and will likely further worsen their general health and quality of life," wrote lead author of the study, William W. Hung, M.D., M.P.H., assistant professor at Mount Sinai School of Medicine.

Patients with COPD may experience periods of hypoxialow oxygen levelsthat might lead to brain abnormalities that could reduce cognitive capacity. Alternatively, hypoxia may cause or exacerbate diseases that are characterized by cognitive impairment, such as Alzheimer's disease. Although past studies have observed a higher rate of cognitive impairment among adults with COPD, the relationship has not been formally tested longitudinally in large populations until now.

"We wanted to determine whether the observed relationship between COPD and cognitive impairment was, in fact, something we could document over time, and if so, we wanted to determine whether the degree to which it occurred was significant," said Dr. Hung.

To do so, Dr. Hung and colleagues obtained data from the Health and Retirement Study, a national prospective biennial survey of Americans 50 and older. They included data from survey takers who had undergone cognitive testing in 1996 and again in 1998, 2000 or 2002.

Of the 4,150 individuals ultimately included, 492 had COPD, and of those, about one-third (153) had severe disease. Using a 35-point cognition scale, the researchers found that scores among all patients with COPD declined on average by one point over the six-year period between 1996 and 2002.

After further classifying those with COPD as having severe or nonsevere disease, the researchers found that severity and cognitive decline were linked. Even after controlling for sociodemographic characteristics and other confounding factors, the mean cognition scores for those with severe COPD were significantly lower (0.9 points; p=0.01) than those without COPD.

"These objective measures of cognition used in survey research do correlate with functional impairment," said Dr. Hung. In particular, executive functions that require greater cognitive ability, such as handling money and medications, are more poorly performed at greater levels of cognitive impairment. Extrapolating from past research using the same cognitive test, Dr. Hung and colleagues suggest that their findings would likely be associated with a 22 percent increase in the mean number of difficulties the severe COPD population would experience with daily tasks.

"While this number may not appear to be of major concern on the individual level, on a population level, it is roughly equivalent to nearly a quarter of severe COPD patients experiencing difficulty with a basic life skill," said Dr. Hung. "In this regard, these findings have serious implications. Often patients with cognitive difficulties, if undetected and untreated, have lower adherence to their treatment and follow-up regimens, and as a consequence may deteriorate more rapidly and have worse health outcomes."

In conclusion, Dr. Hung suggested that physicians and other clinical staff managing the care of these patients should be aware of their increased risk for cognitive decline and the greater needs and challenges associated with caring for cognitively impaired older adults.


'/>"/>

Contact: Keely Savoie
kgsavoie@gmail.com
315-212-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Antidepressants aid electroconvulsive therapy in treating severe depression
2. Patients with moderate to severe periodontitis need evaluation for heart disease risk
3. NUCYNTA(TM) (tapentadol) CII Immediate Release Tablets Now Available for Relief of Moderate to Severe Acute Pain
4. Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
5. Physiological response may explain why some severely obese patients overeat
6. Severe Nightmares May Warn of Suicidal Symptoms
7. MDCT angiography leads to successful treatment of severely blocked arteries in the legs
8. Glucose metabolism and recidivism of severe violent crimes in alcohol intoxications
9. Cottonseed-based drug shows promise in treating severe brain cancer
10. IBI Research Finds Employers Severely Underestimate the Prevalence and Lost Productivity Costs of Depression
11. Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
Breaking Medicine Technology: