Navigation Links
Seven New Cholesterol Genes Discovered

Study finds only those that regulate LDL levels influence heart disease risk

SUNDAY, Jan. 13 (HealthDay News) -- Seven new cholesterol-regulating genes, some of which influence the risk of heart disease, have been identified in an international study of almost 20,000 people in three countries.

"I would predict that some of these genes will be the targets for future drugs," said the study's senior author, Goncalo Abecasis, an associate professor of biostatistics at the University of Michigan School of Public Health.

In their report, published in the Jan. 13 issue of Nature Genetics., the researchers also confirmed the role of 11 previously identified cholesterol-related genes in the risk of heart disease.

"What was most exciting was that only the genetic changes that affect LDL cholesterol influence the risk of heart disease," Abecasis said. "Every genetic change that raises the level of LDL cholesterol influences the risk of heart disease."

LDL cholesterol is well known to be the "bad" kind that forms plaques that eventually can block arteries, causing heart attacks and other cardiovascular troubles. LDL cholesterol is the target of statins, drugs given to reduce coronary risk. HDL cholesterol is the "good" kind, which does not contribute to plaque formation.

"The conventional wisdom is that HDL cholesterol is good for you," Abecasis said. "But in our studies we found no major impact from those genes changing HDL cholesterol levels."

The research, done in collaboration with University of North Carolina and Harvard University researchers, started with genetic studies of 8,800 people from Italy, Sweden and Finland.

The researchers examined more than 2 million genetic variations in those individuals, eventually concentrating on 25 genetic variants, which together are responsible for about 25 percent of levels of blood lipids such as cholesterol.

The study associated incidence of different variants with the incidence of heart disease in those individuals. The results were then confirmed in a study of 11,000 individuals from the three populations.

Future research centering on the newly identified genes could produce "drugs that are as effective as statins in affecting the risk of heart disease," Abecasis said.

Another paper in the same issue of the journal reported the possible discovery of the long-sought "thrifty gene," whose existence was proposed more than three decades ago.

A study of more than a half-million genetic variants in 2,000 Europeans and Indian Asians found that a gene designated MLXIPL works the way the thrifty gene is said to do, turning excess blood glucose into fat tissue.

"These genes are advantageous during times of famine," said research leader Dr. James Scott, a professor of cardiovascular medicine at Imperial College in London.

However, in this era of plenty, the thrifty gene can be a serious problem.

"It's hard to say we've proved that it is a thrifty gene," Scott said. "But it looks like it has all the characteristics of such a gene. We hope this goes a long way toward proving it."

The thrifty gene would be "part of the very complex genetics of a complex disease such as obesity or of heart disease," Scott said. "This would be another step on the pathway of understanding why a person's family history is an indication of the risk of cardiovascular disease."

More information

The different cholesterols are described by the American Heart Association.

SOURCES: Goncalo Abecasis, Ph.D., associate professor, biostatistics, University of Michigan School of Public Health, Ann Arbor; James Scott, M.D., professor, cardiovascular medicine, Imperial College, London; Jan. 13, 2008, Nature Genetics

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Health Level Seven Appoints John Quinn as CTO
2. AMERIGROUP Contracts with Federal Government to Offer Medicare Advantage Health Plans in Seven States
3. Kaiser Permanente Study Shows One in Seven Women are Depressed Before, During, or After Pregnancy
4. Hospital Corporation of America Purchases Seventh CyberKnife(R) System
5. Seven Finalists Announced for 2007 Insight Award for Customer Advocacy in Healthcare
6. New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos
7. President Musevenis Visit Protested by HIV/AIDS Experts
8. HealthPartners is National Benchmark in Six Out of Seven Areas in National Business Coalition on Health Report
9. CNN Honors Extraordinary Deeds of Seven Everyday People in Global Event
10. Medifast, Inc. Receives Approval to Sell Medifast Weight Control Centers Franchises in Seven Additional States
11. Seven Community Service Organizations Granted Over $60,000 From Delta Dental Of Illinois
Post Your Comments:
Related Image:
Seven New Cholesterol Genes Discovered
(Date:12/1/2015)... , ... December 01, 2015 , ... ... has announced its acquisition by Jordan Industries International, LLC (“JII”). , With support ... equipment rentals and maintenance services to hospitals, surgery centers, clinics, research labs and ...
(Date:12/1/2015)... ... December 01, 2015 , ... According to an article published ... discrimination claim against the U.S. Department of Health and Human Services, claiming that any ... plans are breaking the clause in the law prohibiting the denial of coverage for ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... leadless pacemakers in the U.S. and is the only hospital in the region ... largest clinical data presentation of transcatheter pacing patients were revealed recently at a ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Paul Vitenas, one ... Surgery, has been named by MedEsthetics magazine as the Best Single Physician Practice in ... among the many elite aesthetic physicians honored by the industry publication. , Dr. ...
(Date:12/1/2015)... ... December 01, 2015 , ... Growth in medical payments per ... decreases in utilization of hospital and nonhospital care, according to a recent study by ... for Louisiana, 16th Edition , found medical payments per claim with more than seven ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Dec. 1, 2015 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... chronic pain, announced today that the company will present at ... December 1-3 at the Luxe Sunset Boulevard Hotel in ... CEO of Relmada Therapeutics, will present on Thursday, December 3, ... . Please register at least 10 minutes prior ...
(Date:12/1/2015)... , Dec. 1, 2015 CytRx Corporation (NASDAQ: ... specializing in oncology, today announced that it has reached ... pivotal global Phase 3 clinical trial of aldoxorubicin in ... originally estimated to be completed in Q1 2016. The Phase ... under a Special Protocol Assessment from the FDA at ...
(Date:12/1/2015)... , Dec. 1, 2015  Today, ... the launch of CareFront, a first-of-its-kind population health ... diagnosed with cancer. Designed to be built into ... cancer patients with resources for their care and ... program also offers tools to help patients understand ...
Breaking Medicine Technology: