Navigation Links
Seven New Cholesterol Genes Discovered
Date:1/13/2008

Study finds only those that regulate LDL levels influence heart disease risk

SUNDAY, Jan. 13 (HealthDay News) -- Seven new cholesterol-regulating genes, some of which influence the risk of heart disease, have been identified in an international study of almost 20,000 people in three countries.

"I would predict that some of these genes will be the targets for future drugs," said the study's senior author, Goncalo Abecasis, an associate professor of biostatistics at the University of Michigan School of Public Health.

In their report, published in the Jan. 13 issue of Nature Genetics., the researchers also confirmed the role of 11 previously identified cholesterol-related genes in the risk of heart disease.

"What was most exciting was that only the genetic changes that affect LDL cholesterol influence the risk of heart disease," Abecasis said. "Every genetic change that raises the level of LDL cholesterol influences the risk of heart disease."

LDL cholesterol is well known to be the "bad" kind that forms plaques that eventually can block arteries, causing heart attacks and other cardiovascular troubles. LDL cholesterol is the target of statins, drugs given to reduce coronary risk. HDL cholesterol is the "good" kind, which does not contribute to plaque formation.

"The conventional wisdom is that HDL cholesterol is good for you," Abecasis said. "But in our studies we found no major impact from those genes changing HDL cholesterol levels."

The research, done in collaboration with University of North Carolina and Harvard University researchers, started with genetic studies of 8,800 people from Italy, Sweden and Finland.

The researchers examined more than 2 million genetic variations in those individuals, eventually concentrating on 25 genetic variants, which together are responsible for about 25 percent of levels of blood lipids such as cholesterol.

The study associated incidence of different variants with the incidence of heart disease in those individuals. The results were then confirmed in a study of 11,000 individuals from the three populations.

Future research centering on the newly identified genes could produce "drugs that are as effective as statins in affecting the risk of heart disease," Abecasis said.

Another paper in the same issue of the journal reported the possible discovery of the long-sought "thrifty gene," whose existence was proposed more than three decades ago.

A study of more than a half-million genetic variants in 2,000 Europeans and Indian Asians found that a gene designated MLXIPL works the way the thrifty gene is said to do, turning excess blood glucose into fat tissue.

"These genes are advantageous during times of famine," said research leader Dr. James Scott, a professor of cardiovascular medicine at Imperial College in London.

However, in this era of plenty, the thrifty gene can be a serious problem.

"It's hard to say we've proved that it is a thrifty gene," Scott said. "But it looks like it has all the characteristics of such a gene. We hope this goes a long way toward proving it."

The thrifty gene would be "part of the very complex genetics of a complex disease such as obesity or of heart disease," Scott said. "This would be another step on the pathway of understanding why a person's family history is an indication of the risk of cardiovascular disease."

More information

The different cholesterols are described by the American Heart Association.



SOURCES: Goncalo Abecasis, Ph.D., associate professor, biostatistics, University of Michigan School of Public Health, Ann Arbor; James Scott, M.D., professor, cardiovascular medicine, Imperial College, London; Jan. 13, 2008, Nature Genetics


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Health Level Seven Appoints John Quinn as CTO
2. AMERIGROUP Contracts with Federal Government to Offer Medicare Advantage Health Plans in Seven States
3. Kaiser Permanente Study Shows One in Seven Women are Depressed Before, During, or After Pregnancy
4. Hospital Corporation of America Purchases Seventh CyberKnife(R) System
5. Seven Finalists Announced for 2007 Insight Award for Customer Advocacy in Healthcare
6. New Poll Finds Nearly Seven in 10 New Jersey Voters Support Smoke-Free Casinos
7. President Musevenis Visit Protested by HIV/AIDS Experts
8. HealthPartners is National Benchmark in Six Out of Seven Areas in National Business Coalition on Health Report
9. CNN Honors Extraordinary Deeds of Seven Everyday People in Global Event
10. Medifast, Inc. Receives Approval to Sell Medifast Weight Control Centers Franchises in Seven Additional States
11. Seven Community Service Organizations Granted Over $60,000 From Delta Dental Of Illinois
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Seven New Cholesterol Genes Discovered
(Date:3/24/2017)... ... March 24, 2017 , ... Judy Buchanan, co-owner ... in Frederick, MD. Judy says, “I am passionate about sharing Reiki as a ... very difficult and challenging time.” , A Certified Medical Reiki™ Master trained by ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Vintage and Harvest A Cultivation ... and college Bible teacher residing in North Carolina with his wife, Anna Marie. He ... them with six grandchildren. David is also the author of “Shadow and Substance.” , ...
(Date:3/23/2017)... ... 2017 , ... In 2016 the World Health Organization declared the Zika virus ... Zika-related cases in the Americas within the next year. Lyme disease is one of ... skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect borne illnesses are ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... their communities, 16 more public health departments have been awarded national accreditation through ... 4.5 million people into the expanding network of communities across the nation whose ...
(Date:3/23/2017)... , ... March 23, 2017 , ... The IoT (Internet ... WiFi connectivity are making a huge impact on businesses and individual consumers alike. ... the IoT will have a value anywhere from $4 trillion to $11 trillion dollars ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 23, 2017  Mirabilis Medical, a ... for non-invasive surgery, announced today CE Mark authorization ... of uterine fibroids throughout the European Union.  The ... from the US Food and Drug Administration to ... in the United States.  The Mirabilis System combines ...
(Date:3/24/2017)... GENEVA , March 24, 2017 ... revitalizes efforts to develop sutezolid as effective response to ... Day, TB Alliance and the Medicines Patent Pool (MPP) ... sutezolid, an antibiotic drug candidate which demonstrated encouraging results ... of sutezolid in combination with other TB drugs and ...
(Date:3/23/2017)... DUBLIN , Mar 23, 2017 Research ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... CAGR of around 6.9% over the next decade to reach approximately ... market estimates and forecasts for all the given segments on global ...
Breaking Medicine Technology: