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Seven Clinical Presentations on Tapentadol Immediate Release for Acute Pain to Be Featured at 2008 American Pain Society Annual Meeting
Date:5/7/2008

Phase 3 Safety and Efficacy Studies Will Be Highlighted

TAMPA, Fla., May 7 /PRNewswire-USNewswire/ -- Acute pain is a significant medical issue in the United States. More than 25 million Americans are said to experience acute pain each year as a result of injuries or surgeries, and a recent study estimated that 42 percent of U.S. hospital emergency department visits were due to pain-related problems.

Seven clinical presentations on tapentadol immediate release (IR) tablets for acute pain, including pivotal Phase 3 safety and efficacy and gastrointestinal tolerability data, will be discussed during the poster sessions of the 27th Annual Scientific Meeting of the American Pain Society (APS) in Tampa, Florida on Thursday, May 8 and Friday, May 9.

These data presentations are supported by Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD).

Tapentadol is a novel investigational, centrally acting oral analgesic. It has a unique profile with two mechanisms of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition in a single molecule. It is being developed in immediate-release formulation for acute pain and extended-release formulation for chronic pain.

Mu-opioid agonists are drugs that bind to and activate mu-opioid receptors in the central nervous system. These drugs modify sensory and affective (mood) aspects of pain, inhibit the transmission of pain at the spinal cord and affect activity at parts of the brain that control how pain is perceived. Norepinephrine reuptake inhibitors are a type of central nervous system medication that increases the level of norepinephrine in the brain by inhibiting its re-absorption into nerve cells; these compounds have analgesic properties.

The following tapentadol immediate release studies will be presented at APS:

Thursday, May 8: 4:45 p.m. to 6:15 p.m.

Poster 223: Evidence for a Combined Mode of Action Unde
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SOURCE Johnson & Johnson Pharmaceutical Research & Development,L.L.C.
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