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Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
Date:6/29/2011

HOUSTON -- (June 30, 2011) The genome of the most common form of ovarian cancer is characterized by a few common gene mutations but also surprisingly frequent structural changes in the genome itself, said members of The Cancer Genome Atlas (http://cancergenome.nih.gov/), including the Baylor College of Medicine (www.bcm.edu) Human Genome Sequencing Center (www.hgsc.bcm.tmc.edu/), that sequenced and analyzed more than 300 such tumors. The study was the first to achieve an overview of this type of ovarian cancer.

"We found that ovarian cancer has a dramatic pattern of genomic disruption," said Dr. Richard Gibbs (www.hgsc.bcm.tmc.edu/content-home-HGSC_director-x.hgsc) , director of the Baylor Human Genome Sequencing Center and an author of the report that appears in the current issue of the journal Nature (www.nature.com). The BCM Center completed one-quarter of the sequencing.

Ovarian carcinoma (a form of cancer) is the fifth leading cause of cancer deaths among women in the United States. An estimated 21,880 cases and 13,850 deaths from the disease occurred in 2010. More than 70 percent of patients are not diagnosed until they have an advanced stage form of the disease, and the most common kind of ovarian cancer is serous ovarian adenocarcinoma a high-grade form of which was sequenced by the researchers in this project. The National Cancer Institute (www.cancer.gov) and the National Human Genome Research Institute (http://www.genome.gov/) of the National Institutes of Health (www.nih.gov) funded this project.

The researchers said in their report that the spectrum of gene mutations in the study "was surprisingly simple."

The study found that 96 percent of
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Contact: Glenna Picton
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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