Navigation Links
Sepsis Plus Heart Rhythm Disorder Linked to Stroke, Death
Date:11/13/2011

SUNDAY, Nov. 13 (HealthDay News) -- Patients who develop atrial fibrillation -- a heart rhythm disorder -- for the first time while they are hospitalized with severe sepsis are at increased risk for stroke and death, a new study finds.

Atrial fibrillation (AF) is one of the most common heart rhythm problems among critically ill patients, according to background study information. Six percent to 20 percent of patients with severe sepsis develop new-onset atrial fibrillation, which suggests that severe sepsis may contribute to the condition, the researchers wrote.

Their analysis of 2007 data from California hospitals showed that patients with severe sepsis accounted for 14 percent of all new-onset atrial fibrillation that occurred in hospitalized patients. The researchers also found that patients with severe sepsis were nearly seven times more likely to develop new-onset AF than those without severe sepsis.

Factors associated with increased risk of new-onset atrial fibrillation in patients with severe sepsis included; being older, white and male; a history of heart failure, obesity, cancer and stroke; and organ failures, respiratory failure and renal failure.

Developing the faulty heart rhythm increased the risk of ischemic stroke (reduced blood flow to the brain) and death among patients hospitalized with severe sepsis. In-hospital ischemic stroke occurred in 75 of 2,896 (2.6 percent) with new-onset atrial fibrillation, compared with 57 of 9,986 (0.57 percent) with preexisting AF and 249 of 36,200 (0.69 percent) without AF.

In-hospital death occurred in 56 percent (1,629) of severe sepsis patients with new-onset atrial fibrillation and 39 percent (18, 027) of those without it.

The researchers said a number of factors might explain the increased stroke risk in this group of patients with severe sepsis.

"Severe sepsis alone may be associated with an increased risk of stroke through hemodynamic [blood circulation] collapse, increased systemic inflammation, and coagulopathy [clotting/bleeding disorder]. New-onset AF may simply be a marker for greater severity of illness and, thus, greater stroke risk," wrote Dr. Allan J. Walkey, of the Boston University School of Medicine, and colleagues.

The study appears online Nov. 13 in the Journal of the American Medical Association and will be presented at the American Heart Association annual meeting in Orlando, Fla.

"Given projected estimates of severe sepsis incidence in 1 million Americans in 2011, it is likely that new-onset AF occurs in more than 60,000 patients with severe sepsis in the United States each year," the researchers wrote.

"Current guidelines do not address AF that occurs in the setting of severe sepsis or acute infection, suggesting that new-onset AF that occurs during severe sepsis is an underrecognized public health problem. If our findings of increased stroke and death in the setting of AF and severe sepsis are replicated in other data sets, then it will be important to examine management strategies that might diminish the risk of adverse outcomes associated with AF during severe sepsis."

More information

The U.S. National Heart, Lung, and Blood Institute has more about atrial fibrillation.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Nov. 10, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hospital-Acquired Sepsis, Pneumonia a Growing Menace
2. Two Sepsis Treatments Look Equally Effective
3. Fast sepsis test can save lives
4. The death switch in sepsis also promotes survival
5. Gene protects lung from damage due to pneumonia, sepsis, trauma, transplants
6. Hospital Spending Doesnt Affect Sepsis Survival Rates
7. Roundworm could provide new treatment for sepsis
8. Streptococci and E. coli continue to put newborns at risk for sepsis
9. Study: Resiniferatoxin may increase sepsis-related mortality
10. Quicker detection and treatment of severe sepsis
11. U.S. Stroke Belt May Also Be Sepsis Belt
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sepsis Plus Heart Rhythm Disorder Linked to Stroke, Death
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
Breaking Medicine Technology: