Navigation Links
Separating a cancer prevention drug from heart disease risk
Date:9/13/2011

Several clinical studies have shown that taking the anti-inflammatory drug celecoxib can reduce the risk of developing polyps that lead to colon cancers, at the cost of increasing the risk of heart disease. But what if this tradeoff was not necessary?

Researchers at Winship Cancer Institute of Emory University have identified a way that celecoxib (Celebrex) pushes cancer cells into suicide, separately from its known effects. The Winship team's results outline a route to alternatives to celecoxib that keep its cancer-preventive properties while avoiding its risks.

Celecoxib's risk profile has confined its use to people who have inherited cancer risk or those who have had cancer already. Its effectiveness at stopping tumor progression and recurrence is being tested in several clinical trials for people who have had lung, head and neck and other types of cancer.

Shi-Yong Sun, PhD, and colleagues report in an upcoming issue of the journal Cancer Research that celecoxib inhibits an enzyme called GSK3 (glycogen synthase kinase 3) in lung cancer cells. This causes the disappearance of a protein called c-FLIP, which usually staves off apoptosis, a form of cellular suicide.

"We have been focusing on how celecoxib induces c-FLIP degradation and apoptosis in cancer cells, independent of COX-2 inhibition," Sun says.

Scientists think that celecoxib's ability to inhibit COX-2 enzymes is the basis for its anti-inflammatory properties as well as its influence on heart disease.

Sun is professor of hematology and medical oncology at Emory University School of Medicine and a Georgia Cancer Coalition Distinguished Cancer Scholar. The first author of the paper, postdoc Shuzhen Chen, is now at the Chinese Academy of Medical Sciences' Institute of Medicinal Biotechnology in Beijing. Fadlo Khuri, MD, deputy director of Winship Cancer Institute, is a co-author on the paper.

The result was surprising partly because until a few years ago, scientists thought that inhibiting GSK3, while possibly helpful in diseases such as diabetes, could promote cancer. However, recent results suggest that blocking GSK3 may stop cell growth in prostate, pancreatic and colon cancers and some types of leukemia.

Sun cautions: "We do not know whether GSK3 inhibition by celecoxib has anything to do with celecoxib's cardiovascular risk."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. Web tool aims to improve the workplace for breast cancer survivors
2. IUD reduces the risk of cervical cancer
3. IUDs May Lower Womens Risk for Cervical Cancer: Study
4. Women With BRCA Mutations Get Cancer Diagnosis Earlier Than Before
5. NSAID Painkillers Linked to Risk of Kidney Cancer
6. X-ray protein probe leads to potential anticancer tactic
7. Lung cancer signatures in blood samples may aid in early detection
8. Women who inherit BRCA gene mutations develop cancer earlier than their ancestors
9. Breast cancer patients with BRCA gene diagnosed almost 8 years earlier than generation before
10. Moffitt Cancer Center researchers use new tool to counter multiple myeloma drug resistance
11. Talking -- or Not Talking -- Can Give Cancer Patients a Sense of Control
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... MEDIA OPPORTUNITY: , Save Our ... interview citizens on why they are rallying against Mayo Clinic. Specifically, media can talk ... against Dr. Noseworthy’s (CEO) decision to close the Albert Lea hospital. , The rally ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... buildings, and Richard Pedranti Architect (RPA), a full-service architecture firm focusing ... partner’s Solsken Line of Model Homes . Independently, Ecocor and RPA have ...
(Date:9/22/2017)... ... ... Happy Living’s mission - to improve the health and wellbeing of the ... delicious worlds of theatre and wines. , After watching Scott Barry perform on ... play into a book. The Greener The Grass ( https://www.happyliving.com/books/the-greener-the-grass ) was published on ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... of independent freestanding emergency rooms is celebrating the one year anniversary of its ... our facility opening,” said Dr. Otinwa, Facility Medical Director of First Choice Emergency ...
(Date:9/22/2017)... ... 22, 2017 , ... “Letters From Home”: a moving compilation of letters ... to God. “Letters From Home” is the creation of published author, John Allred, a ... of Jerry Savelle Ministries International, who has traveled and ministered on four continents. , ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Texas , Sept. 7, 2017 ... science focused on fulfilling the promise of precision ... further validate the benefits of its molecular profiling ... study utilized comprehensive genomic profiling plus (CGP+) with ... individual patient,s tumor on a molecular level, leading ...
(Date:9/7/2017)... 7, 2017   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade cell and tissue hypothermic storage ... Mike Rice , President and CEO, will be presenting at ... Rodman & Renshaw 19 th Annual Global Investment Conference ... p.m. Pacific time). The conference is being held at the ...
(Date:9/6/2017)...   PDI , a leader in infection prevention ... educational session focused on the role of chlorhexidine gluconate ... the 2017 Annual Scientific Meeting of the Association for ... the Phoenix Convention Center in ... will also feature PDI,s Prevantics® Device Swab ...
Breaking Medicine Technology: