Navigation Links
Sentinel node biopsy safe, effective in head and neck melanomas, U-M study finds
Date:8/5/2011

This release is available in Spanish.

ANN ARBOR, Mich. A common technique for determining whether melanoma has spread can be used safely and effectively even in tumors from the head and neck area, according to a new study from the University of Michigan Comprehensive Cancer Center.

Sentinel lymph node biopsy involves injecting a special dye to identify the first node where cancer would likely spread. If that node is clean, patients can avoid further debilitating surgery to remove multiple lymph nodes. If that node shows cancer, patients know they need the more extensive surgery or further treatment with radiation, chemotherapy or a clinical trial. Patients with melanoma of a certain size or larger are routinely offered this procedure.

But many surgeons believed that the complex anatomy combined with the critical nerves and blood vessels in the head and neck area made sentinel lymph node biopsy unsafe and inaccurate for melanomas in that region.

In the current study, which appears online in Cancer, researchers looked at 353 head and neck melanoma patients who had received sentinel lymph node biopsy at U-M over a 10-year period. After reviewing patients' records, the researchers found that the sentinel lymph node could be identified in all but one patient, and no patients sustained permanent nerve injuries during the procedure.

About 20 percent of the patients had at least one sentinel node positive for cancer and were referred for a complete dissection to remove additional lymph nodes.

Among the remaining 283 patients with negative sentinel nodes, 12 patients recurred in the region where the sentinel lymph node was identified. This suggests that the test yielded 12 false-negative results, which means a negative test was incorrect 4 percent of the time. This rate is similar when sentinel lymph node biopsy is used for melanomas in other parts of the body.

"Sentinel lymph node biopsy is a safe and effective way to determine the status of the regional nodal basin for melanomas affecting the head and neck region. Furthermore, our study showed that it can be done accurately for these patients," says study author Carol Bradford, M.D., professor and chair of otolaryngology at the U-M Medical School.

The researchers also found that sentinel lymph node biopsy was the biggest predictor of how well a patient would do after surgery, including overall survival as well as recurrence-free survival.

"This procedure should be offered in patients with head and neck melanomas the same as patients with melanomas in other parts of the body. Not only is sentinel lymph node biopsy feasible and safe in these patients, but it helps determine the best course of treatment to offer patients the best hope of survival," Bradford says.

The authors stress the need for patients with head and neck melanoma to seek out a specialist in head and neck cancer surgery and sentinel lymph node biopsy. The Multidisciplinary Melanoma Clinic at the U-M Comprehensive Cancer Center includes specialty surgeons highly skilled in performing this procedure.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. The sentinel node dilemma in breast cancer surgery
2. Microbubbles to light the way to sentinel lymph nodes of breast cancer patients
3. Sentinel Life Medicare Supplement – Significant Commission Increase Announced
4. MedPage Today(R) and Milwaukee Journal Sentinel Develop Journalism Content Collaboration for Enterprise Medical Reporting
5. For Many, Risks of Lung Biopsy May Outweigh Benefits: Study
6. Noninvasive diagnostics may offer alternative to liver biopsy for assessing liver fibrosis
7. Shave biopsy is a safe and acceptable method for initial evaluation of melanoma
8. New technology fuses MRI, ultrasound to achieve targeted biopsy of prostate cancer
9. Closely monitoring low-risk prostate cancer, with biopsy, does not raise risk of death
10. Elastography helps identify patients who need biopsy
11. Virtual biopsy may allow earlier diagnosis of brain disorder in athletes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sentinel node biopsy safe, effective in head and neck melanomas, U-M study finds 
(Date:12/2/2016)... ... December 02, 2016 , ... Two years ago, Arizona State ... watched live by 1 million viewers and won numerous honors, including the region’s ... at the Walter Cronkite School of Journalism and Mass Communication are following up ...
(Date:12/2/2016)... Angeles, CA (PRWEB) , ... December 02, 2016 , ... For over twenty-four years, ... lien basis to help personal injury victims find high quality medical care. When the ... Los Angeles area. Fast forward to present day and the now ten-page directory features ...
(Date:12/2/2016)... ... December 02, 2016 , ... Advanced Inc., a leading provider of ... Bice, CPA, MBA to serve as Advanced Inc.’s Chief Financial Officer, effective December 1, ... Jason brings extensive financial and operational leadership experience to Advanced Inc. He began his ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... U.S. Surgeon ... interview with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at ... learned that medicine is about more than making diagnoses and prescribing medicine,” he states. ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... December 2, 2016 According ... Diagnostics/IVD Market by Product (Instruments, Reagents, Software), Technology ... Oncology, Cardiology, Nephrology, Infectious Diseases) - Forecast to ... valued at USD 60.22 Billion in 2016. This ... of 5.5% during the forecast period (2016-2021) to ...
(Date:12/2/2016)...  The Addiction Treatment Advisory Group (ATAG), created ... Pharmacy (AMCP), has released detailed findings on how ... addiction crisis, including through improved access to naloxone ... newly released paper, "The Role of Managed Care ... issues around gaps and barriers to addiction treatment ...
(Date:12/2/2016)... , Dec. 2, 2016 Boston Scientific ... definitive agreement to acquire certain manufacturing assets and capabilities ... (TSX: NVC) advanced biological tissue business, as well as ... of $75 million in cash. The Neovasc advanced biological ... including the Boston Scientific Lotus™ Valve System. * ...
Breaking Medicine Technology: