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Senetek PLC Announces North American Partner for Invicorp(R) Secures Financing for Advancement of Marketing and Development Efforts
Date:4/1/2008

ibility for the drug regulatory process for Invicorp(R) in North America and for establishing this breakthrough therapy in the North American market. Senetek will participate with Plethora in the success of Invicorp(R) in North America through royalties based on net sales of Invicorp(R) plus predetermined multi-million dollar milestone payments upon achievement of regulatory approvals and cumulative net sales targets.

Plethora has initiated the U.S. Phase III trial for Invicorp(R) and meetings with the FDA have confirmed the path to submission of the NDA for Invicorp(R) as a front-line therapy for erectile dysfunction (ED). The anticipated market potential in North America is in the range of $150 - 200 million in annual sales.

Invicorp(R) is a highly safe and effective treatment for erectile dysfunction (ED), a condition that affects more than 100 million men worldwide. Invicorp(R) has shown excellent results in a wide range of patients, many of whom have failed on other therapies for the treatment of ED. In completed Phase III clinical trials conducted in the United Kingdom, Denmark, Ireland and Australia, Invicorp(R) demonstrated outstanding efficacy and safety. The market for non-oral drugs is an important, growing segment of the total ED market where existing oral treatments are associated with a number of side effects and are contra-indicated for a large number of individuals including those with diabetes and those receiving nitrate therapies for angina.

Commenting on this development, Frank Massino, Chairman and Chief Executive Officer of Senetek stated, "We are pleased that Invicorp(R) has received this strong endorsement that will help serve to accelerate the Invicorp(R) development program, as leading urologists are eager to add this important therapy to their armamentarium for the treatment of the many patients who are contraindicated for, or unresponsive to oral therapies."

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