Navigation Links
Senesco Announces Results of Pre-Clinical Efficacy, Toxicology and Dose Ranging Studies for Multiple Myeloma Therapeutic Candidate
Date:2/3/2009

9-week repeated dose study in normal mice, was designed to assess toxicity following long-term administration of twice-weekly therapeutic doses (1.5 mg/kg) of SNS-01. This study also included a group of mice that were dosed with a mouse-specific eIF5A siRNA to determine whether there were any toxic effects of suppressing eIF5A in mouse tissues. The change in mean body weight of the treated and untreated mice was exactly the same over the course of the study. In addition to the indices studied in the maximum tolerated dose experiment, hematology was monitored in this experiment. Over the course of six weeks, both the mean red blood cell count (9.8 for control mice, 9.6 for treated mice) and white blood cell count (7.5 for control mice, 7.2 for treated mice) remained consistent, further supporting the conclusion that SNS-01 was non-toxic in these studies. Histopathological analysis of the major organs was conducted by an independent pathologist and revealed no toxicity attributable to SNS-01.

Richard Dondero, Senesco's Vice President of Research and Development commented, "These mouse efficacy studies allowed us to determine a proposed therapeutic dose range for SNS-01. The results of our pre-clinical toxicology and dose-ranging studies indicate a maximum tolerated dose 2-4 times higher than those producing anti-tumor effects in mice."

It is Senesco's goal to file an Investigational New Drug Application for SNS-01 before the end of calendar year 2009. The Company will need to conduct longitudinal toxicology studies and meet with the FDA during this process.

About SNS-01

Senesco's SNS-01 consists of three components: an eIF5A plasmid, an siRNA against eIF5A and polyethyleneiminie (PEI). The eIF5A plasmid upregulates the apoptotic pathways within cancer cells. The siRNA downregulates proinflammatory cytokines, NF-kB and ICAM, which are proliferation factors for multiple myeloma. PEI i
'/>"/>

SOURCE Senesco Technologies, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Senesco Technologies to Present at 10th Annual Rodman & Renshaw Healthcare Conference
2. Senesco Expands on Preclinical Multiple Myeloma Findings
3. MAP Pharmaceuticals Announces Expiration of Hart-Scott-Rodino Waiting Period for Unit Dose Budesonide Collaboration with AstraZeneca
4. SmartNow.com Announces the Appointment of Dr. Melina Jampolis as Chief Medical Officer
5. Carriage Services Announces Fourth Quarter Earnings Release And Conference Call Schedule
6. Weight Watchers Announces Fourth Quarter and Full Year 2008 Earnings Conference Call
7. Hudsonville Ice Cream Announces Recall
8. American Dietetic Association Announces Agenda for Health Reform
9. Hologic Announces First Quarter Fiscal 2009 Operating Results
10. Arizona Heart Institute Announces FREE Public Forum Featuring Live Viewing of Surgical Procedures Via High-Definition (HD) Satellite
11. Aflac Incorporated Announces Fourth Quarter Results, Sees 2008 RBC Ratio Above 450%, Affirms 2009 Operating EPS Target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... December 25, 2014 Recently, LunaDress.co.uk has updated its ... and related accessories. Now, all of the models at LunaDress.co.uk come ... a groom lifts the wedding veil can turn out to be ... charm. A wedding veil can always bring surprise to a wedding. ... on how to choose veils for a big day . ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Overeating is common during the holidays, ... moderation, an expert says. "Don,t arrive at a party ... you know you,ll be attending a party, but deprivation leads ... dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., said ... healthy during the day and even to have a snack ...
(Date:12/25/2014)... 2014 AngelWeddingDress.com tries its best to ... realm. Today, the business has introduced its new collection ... dress promotion. , The new prom outfits are guaranteed ... dress lover. They are specially designed for 2015. Anyone ... dresses should visit its website before Jan. 26, 2015, ...
(Date:12/25/2014)... Viejo, California (PRWEB) December 25, 2014 ... release of ProFire 5k. A fully customizable business presentation ... . , “Adding the ProFire 5k business tool, users ... Said Christina Austin, CEO of Pixel Film Studios. “ProFire ... look and style to add professionalism to a presentation” ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2
... by Dr Roger Bayston in the School of Clinical Sciences, ... an allied health professional training fellowship of almost 160,000 from ... bacterial infections associated with broken bones. Pins used ... to 40 per cent of patients being treated in this ...
... NY) The American Association for Cancer Research (AACR), ... awarded Susan Band Horwitz, Ph.D. , the Rose ... molecular pharmacology at Albert Einstein College of Medicine ... Achievement in Cancer Research. Dr. Horwitz, who is ...
... 2011 Those light-emitting diodes marketed as safe, environmentally ... and a dozen other potentially hazardous substances, according to ... next generation of lighting. But as we try to ... or contribute to global warming, we have to be ...
... 10 (HealthDay News) -- People are more likely to recall an ... it is over than if they expect it to occur again, ... as equally enjoyable whether they think they,ll do them again or ... discomfort if they have a bad experience and allow them to ...
... at St. Michael,s Hospital and the Institute for Clinical and ... that will help doctors predict the probability of death in ... in the journal Circulation , found that the tool ... and one year after an ischemic stroke. An ischemic stroke, ...
... living in deprived neighbourhoods are twice as likely to have ... Coast, according to a new study by researchers at St. ... of illness and death are significantly higher in poorer neighbourhoords. ... a big role in how strongly they are affected," said ...
Cached Medicine News:Health News:Anti-bacterial collar to help mend broken bones 2Health News:Susan Band Horwitz, Ph.D., of Einstein, receives lifetime achievement award in cancer research 2Health News:Susan Band Horwitz, Ph.D., of Einstein, receives lifetime achievement award in cancer research 3Health News:LED products billed as eco-friendly contain toxic metals, study finds 2Health News:New online tool predicts probability of death from stroke 2Health News:Coastal Canadians living in high-risk neighborhoods in poorer health: Study 2
(Date:12/24/2014)... Pa. , Dec. 24, 2014  Commonwealth Cornerstone Group ... Markets Tax Credits transaction on Tuesday to help fund the ... Network (PHN) in Sharon . ... in Pennsylvania . It is the largest ... with more than 150 people on staff. Currently, ...
(Date:12/24/2014)... , Dec. 24, 2014  Conkwest, Inc., the ... the proprietary Natural Killer (NK) cell-line platform, Neukoplast® ... Patrick Soon-Shiong , NantWorks founder, physician scientist ... agreement to purchase approximately $48 million of the ... the investment, he will be named Co-Chairman of ...
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 2Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 3Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 4Conkwest Announces $50m In Strategic Investments And Appoints NantWorks Founder, Dr. Patrick Soon-Shiong As Co-Chairman Of The Board 5Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... Pharmaceuticals, Inc. (Nasdaq: PPHM ) today announced ... Group in its R&D organization. The new ... the company,s multiple external collaborations already underway or ... phosphatidylserine (PS)-targeting antibody platform for the prevention and ...
... LAKES, N.J., Oct. 7 Medco Health Solutions, Inc. (NYSE: ... find smart solutions for getting the most value out of ... Prescription Plan® has three different plan options - Choice ... in addition to providing access to a vast array of ...
Cached Medicine Technology:Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 2Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 3Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 4Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 5Peregrine Pharmaceuticals Forms Anti-Viral Research Group to Oversee Its Anti-PS Infectious Disease Collaborations 6Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 2Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 3Medco's 2010 Medicare Prescription Drug Plan Helps People Take an Active Part in Lowering Prescription Costs 4
Patented* Design for Endoscopic Shunt Placement. Designed to pass through standard shunt ventricular catheters for optically guided placement....
Preclude Dura Substitute is the only non-biological membrane designed to "seal" around suture holes. 0.3 mm as nominal thickness....
... Lyoplant is a new ... pericardium. A pure collagen implant, ... to three months, replacing implant ... collagen. Its natural structure minimizes ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Medicine Products: