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Self-perpetuating signals may drive tumor cells to spread
Date:7/16/2013

s, prompting more people to withdraw their money, in a kind of self-fulfilling prophecy (or positive feedback loop).

The team went on to show that this positive feedback circuit is switched on in very specific regions in the connective tissue cells, causing proteins to push against only one side of the outer envelope of the cell, eventually causing movement in one preferred direction. Predictably, two important protein components of this signaling circuit, called Ras and PI3K, are often mutated in cancer. This suggests that misregulation of this circuit may increase the invasiveness of cancer cells. It also highlights the need to understand how signaling proteins interact with each other inside cells, hopefully leading one day to new therapies for cancer and other deadly diseases.

This study, entitled "The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts" was published online in Molecular Biology of the Cell on May 15. It is supported by a grant from the Ministry of Education.


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Contact: Catherine Kolf
ckolf@jhmi.edu
410-287-2251
Johns Hopkins Medicine
Source:Eurekalert

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