Navigation Links
Self-assembled viruses
Date:5/30/2008

This release is available in German.

Viruses are true experts at importing genetic material into the cells of an infected organism. This trait is now being exploited for gene therapy, in which genes are brought into the cells of a patient to treat genetic diseases or genetic defects. Korean researchers have now made an artificial virus. As described in the journal Angewandte Chemie, they have been able to use it to transport both genes and drugs into the interior of cancer cells.

Natural viruses are extremely effective at transporting genes into cells for gene therapy; their disadvantage is that they can initiate an immune response or cause cancer. Artificial viruses do not have these side effects, but are not especially effective because their size and shape are very difficult to controlbut crucial to their effectiveness. A research team headed by Myongsoo Lee has now developed a new strategy that allows the artificial viruses to maintain a defined form and size.

The researchers started with a ribbonlike protein structure (-sheet) as their template. The protein ribbons organized themselves into a defined threadlike double layer that sets the shape and size. Coupled to the outside are "protein arms" that bind short RNA helices and embed them. If this RNA is made complementary to a specific gene sequence, it can very specifically block the reading of this gene. Known as small interfering RNAs (siRNA), these sequences represent a promising approach to gene therapy.

Glucose building blocks on the surfaces of the artificial viruses should improve binding of the artificial virus to the glucose transporters on the surfaces of the target cells. These transporters are present in nearly all mammalian cells. Tumor cells have an especially large number of these transporters.

Trials with a line of human cancer cells demonstrated that the artificial viruses very effectively transport an siRNA and block the target gene.

In addition, the researchers were able to attach hydrophobic (water repellant) moleculesfor demonstration purposes a dyeto the artificial viruses. The dye was transported into the nuclei of tumor cells. This result is particularly interesting because the nucleus is the target for many important antitumor agents.


'/>"/>

Contact: Myongsoo Lee
mslee@yonsei.ac.kr
82-221-232-647
Wiley-Blackwell
Source:Eurekalert  

Related medicine news :

1. Monkey Gene That Blocks AIDS Viruses Evolved More Than Once
2. Researchers discover new battleground for viruses and immune cells
3. 6 simple steps to protect against and stop the spread of noroviruses
4. Researchers uncover more about how poxviruses evade the immune system
5. Viruses for a healthy pregnancy
6. McMaster test detects the most prevalent respiratory viruses
7. Common human viruses threaten endangered great apes
8. Influenza: Insights into cell specificity of human vs. avian viruses
9. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
10. Laser blasts viruses in blood
11. New viruses to treat bacterial diseases -- My enemies enemy is my friend
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Self-assembled viruses
(Date:5/2/2016)... , ... May 02, 2016 , ... ... website to help consumers better understand life insurance throughout various life stages. , ... an easy-to-use life insurance needs calculator and content specific to the times when ...
(Date:5/2/2016)... ... May 02, 2016 , ... WestHarbor Growth Partners, a growth, ... release of Grow Healthy Vending’s newly revamped brand campaign. Grow Healthy Vending ... vending providers in North America with locations across the United States as well ...
(Date:5/2/2016)... Naperville, Illinois (PRWEB) , ... May 02, 2016 , ... ... our modernized mail back service. MedPro now offers its mail back service for ... this offer; we are now able to provide service to all of the clients ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Dr. Rassouli, ... dental health and cognitive decline. According to the research, which was published in the ... degree of cognitive decline, and about 5.4 million Americans have Alzheimer’s disease. The study ...
(Date:5/2/2016)... , ... May 02, 2016 , ... According to an ... one in four girls are sexually abused before the age of 18. Of those ... to tell her story and others. , In her new book, Lyah! Lyah! ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 Oramed Pharmaceuticals Inc. (NASDAQ: ... focused on the development of oral drug delivery systems, announced ... 2016 conference, presented by Joseph Gunnar & Co. ... New York . Nadav Kidron , CEO of ... Presentation Details:   PIONEERS 2016, presented ...
(Date:4/28/2016)... 2016 New market research ... a report that provides an overview of the ... by identifying new targets and MOAs to produce ... discussed in this H1 2016 Osteoarthritis Pipeline report ... Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios Therapeutics, ...
(Date:4/27/2016)... 27, 2016   ... in Recurring Consumable Sales  Clinical sales grow ... Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the ... for the first quarter ended March 31, 2016 and ... of its commercial strategy. First Quarter 2016 ...
Breaking Medicine Technology: