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Selexis SA to Present Technology Platform Data at Cell Line Development & Engineering
Date:5/20/2013

Geneva, Switzerland (PRWEB) May 20, 2013

Selexis SA, a serial innovation company focused on drug discovery for lead identification and cell line development for scale-up and manufacturing of therapeutic protein drugs, announced today that the Company’s co-founder will present data on the Company’s core technology at the 2013 Cell Line Development & Engineering Conference, May 20 - 23 at the Hyatt Regency La Jolla at Aventine in La Jolla, California. Selexis’ co-founder and scientific advisory board member, Nicolas Mermod, PhD, Professor of Biotechnology and Faculty of Biology and Medicine at the University of Lausanne, will present, “Engineering the CHO Genome for Improved Transgene Integration and Expression,” on Monday, May 20 at 2:30 PM as part of the Application, Integration and Characterization of 'Omics in Cell Line Development tract.

Additionally, a poster presentation with data from the recently launched SURE CHO-Mplus™ Library, “CHO Cell Library for the Selection of Improved Recombinant Therapeutic Protein Production,” is scheduled to be presented at the conference. The poster presentation will discuss new solutions that address a broad range of recombinant protein secretion issues.

Presentation Abstract:
Epigenetic regulatory DNA elements prevent silencing and increase transgene integration and transcription for high and stable therapeutic production. We have sequenced the genome and transcriptome of a CHO cell line and of derived producer cell clones, yielding information on the integration locus, transgene integrity and copy number. Information on possible mechanisms allowing vector genomic integration was also obtained, providing approaches to further optimize transgen
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