Navigation Links
Selexis SA Launches SURE CHO-Mplus™ Libraries
Date:4/17/2013

Geneva, Switzerland (PRWEB) April 17, 2013

Selexis SA, a serial innovation company focused on drug discovery for lead identification, cell line development for scale-up and manufacturing of therapeutic protein drugs, announced today the launch of its novel platform, SURE CHO-Mplus™ Libraries, which were designed and constructed to address a broad range of issues surrounding recombinant protein secretion including metabolic limitations, trafficking backlogs, improper folding and altered post-translational modifications.

With certain recombinant proteins, optimal expression cannot be achieved by elevated transcription alone. Low productivity can be the result of a myriad of issues including faulty cleavage and protein precipitation, improper folding, metabolic overload, or backlog in protein translocation or vesicle trafficking. Within each of the Company’s SURE CHO-Mplus™ Libraries, between 8-12 secretory components have been modified to address specific secretion bottlenecks, such as aberrant glycosylation or improper protein folding. The SURE CHO-Mplus™ Libraries have been shown to significantly improve production levels of a broad range of proteins including difficult-to-express monoclonal antibodies, enzymes, structural proteins and fusion proteins such as Fc-fusions and minibodies.

“The Selexis SURE CHO-Mplus™ Libraries are a novel and powerful advancement in biologic protein expression. Selexis’ libraries enable a multiplex approach to determine optimal secretory configurations for recombinant proteins,” said Dr. Igor Fisch, CEO, Selexis SA. “With the Selexis SURE CHO-Mplus™ Libraries, biopharmaceutical companies now have solutions for optimizing the commercial viability of biologic development programs including target expression campaigns that would be otherwise terminated because of protein secretion issues.”

The CHO-Mplus™ Libraries that address secretion bottlenecks include:

  •     CHO-Mplus™ ERsec
  •     CHO-Mplus™ ERfold
  •     CHO-Mplus™ VESIC
  •     CHO-Mplus™ GLYCO
  •     CHO-Mplus™ SURVIV
  •     CHO-Mplus™ DNArepair
  •     CHO-Mplus™ PROLIF

About Selexis SA
Headquartered in Geneva, Switzerland, Selexis SA is a global life science company with innovative technologies and world-class expert services for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins. The Company’s SUREtechnology Platform™ is based on Selexis Genetic Elements™ — novel DNA-based elements that control the dynamic organization of chromatin within all mammalian cells and allow for higher and more stable expression of recombinant proteins. Selexis has generated over 1,700 cell lines being used in a variety of programs from drug discovery to late-stage clinical trials.
For more information:

Read the full story at http://www.prweb.com/releases/secretion_bottlenecks/recombinant_proteins/prweb10639998.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Selexis SA to Partner and Exhibit at BIO 2013
2. Selexis SA to Present and Partner at the BIO-Europe Spring
3. Selexis SA Announces Publication in Metabolic Engineering of Data Demonstrating Improvement of Therapeutic Protein Secretion with Engineered CHO Cells
4. Belafonte Launches Glamorous Cosmetics Line; Malena Belafonte Has Designed a Mineral Cosmetics Line for Women and Moms on the Go
5. Web Entrepreneur Launches JuicersAndCoffeeMakers.com, a Website Featuring Quality Kitchen Appliances
6. The Gluten Free Society Launches Gluten Sensitivity and Celiac Disease At-Home Testing
7. Astro-Clairvoyant Norah Guide with Premium Astrology Launches New Blog Series on Jupiter Transits
8. Cody Bramlett, Certified Russian Kettlebell Instructor (RKC), Launches Kettlebell X Boot Camp
9. PCOS Diva Launches Spring Meal Plans For Women With Polycystic Ovarian Syndrome
10. Minnesota Company, Altman Fitness, Launches Guaranteed Weight Loss Campaign
11. WTEC Launches New Website for Full Lineup of Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BROOKLINE, MA (PRWEB) , ... April 28, 2016 , ... ... his revolutionary work in the emerging field of biomechatronics, technology that marries human physiology ... the MIT Media Lab. He is also the Founder of BionX , a ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Management solutions, announces today the availability of its latest software release, NetZoomDC ... capacity management and optimization, providing new analytical capabilities that assess complex capacity ...
(Date:4/28/2016)... ... 28, 2016 , ... One way to ignore solid evidence is to dismiss ... we toss the baby out with the bathwater when we ignore all studies because ... studies and otherwise making better use of education policy research. , “When readers heed ...
(Date:4/28/2016)... ... April 28, 2016 , ... USA Medical Card reminds us that May is National ... stroke is the fourth leading cause of death in the United States; someone has one ... quarter of them in individuals under 65 years old. A stroke is when blood ...
(Date:4/28/2016)... ... April 28, 2016 , ... Anzu®, ... announced a new Residency Education & Collaboration Platform for hospitals and medical ... and a host of collaboration tools designed to improve patient outcomes through ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016   Click here for supplemental information ... DPLO), the nation,s largest independent specialty pharmacy, announced ... to acquire Valley Campus Pharmacy, Inc., doing business ... specialty pharmacy that provides individualized patient care, based ... In 2015, TNH generated approximately $400 million in ...
(Date:4/28/2016)... 2016  While Abbott,s announced purchase of St. ... repair and stent business, healthcare research firm Kalorama ... firmly into patient monitoring.  Kalorama said that patient ... areas, with double-digit growth expected the next 5 ... Remote Patient Monitoring . Abbott Laboratories agreed ...
(Date:4/28/2016)... Research and Markets has announced ... Market 2016-2020" report to their offering. ... The global plastic surgery products market is expected to ... 2016-2020. , ,The growing adoption of laser in aesthetics ... the market. Lasers are used to treat a broad ...
Breaking Medicine Technology: