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Selective inhibition of BMK1 suppresses tumor growth
Date:9/13/2010

and significantly inhibited tumor growth in mice. Importantly XMD8-92 had no obvious negative effects on the animals. "These results demonstrate that the BMK1 pathway can be blocked effectively by a small-molecule inhibitor without apparent adverse effects and, more importantly, BMK1 inhibition is a very effective way to prevent cancer development in animals," concludes Dr. Lee. "As BMK1 is expressed in most tumor cells, our results suggest that cancer therapies targeting BMK1 may be useful for treating diverse types of human tumors."


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Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

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