Navigation Links
Selective inhibition of BMK1 suppresses tumor growth
Date:9/13/2010

A study describing a newly developed pharmacological inhibitor is providing detailed insight into how an enzyme that has been implicated in multiple human malignancies regulates a known tumor suppressor. The research, published by Cell Press in the September 14th issue of the journal Cancer Cell, may have broad application for treating human cancers.

Mitogen-activated protein kinases (MAPKs) are enzymes that regulate multiple cellular activities, including proliferation and cell survival. Mutations in MAPK signaling pathways have been shown to play a significant role in many types of cancer. Of the four different MAPKs that have been identified in mammalian cells, ERK1/2 and BMK1 exhibit significant structural similarity. In fact, recent research has shown that some pharmacological compounds which have been considered to be specific inhibitors of ERK1/2, also interfere with the lesser known BMK1.

"It is critical that results using the common MAPK inhibitors be reevaluated using more specific inhibitors of the BMK1 and ERK1/2 cascades. However, so far there has been no specific small-molecule inhibitor of BMK1 that is effective both in cells and animals," explains senior study author, Dr. Jiing-Dwan Lee, from The Scripps Research Institute in La Jolla, California. "More importantly, the lack of this kind of BMK1 inhibitor has hampered the understanding of the physiological/pathological roles of BMK1."

Dr. Lee and colleagues discovered that promyelocytic leukemia protein (PML), which is a known tumor suppressor, is inhibited by BMK1. "Previous reports had implicated ERK1/2 in the regulation of PML," says Dr. Lee. "However, in our study we found that that BMK1 interacts with PML and suppresses its antitumor actions." To further investigate the BMK1-PML interaction, the researchers developed a compound called XMD8-92 that was remarkably selective at inhibiting BMK1.

Treatment with XMD8-92 blocked tumor cell proliferation
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
2. Bone drug suppresses wandering tumor cells in breast cancer patients
3. Exosomal release of beta-catenin may explain why CD82 and CD9 suppress tumor metastasis
4. In-depth investigation on the capacity of 4-HPR to induce death of tumor cells
5. Tumor budding identified as predictor for unfavorable outcome in lung cancer
6. Journal of Vascular and Interventional Radiology sees growth, promise of tumor ablation
7. With muscle-building treatment, mice live longer even as tumors grow
8. Lung stem cells vital to lung repair associated with poor cancer prognosis when found in tumor
9. A lethal brain tumors strength may be a weakness as well
10. Merlin protein found to control liver stem cells, prevent tumor development
11. New drug reduces tumor size in women with advanced hereditary ovarian or breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of chronic inflammation in non-cancerous prostate tissue may have ... than those with no inflammation, according to results of ... Hopkins Kimmel Cancer Center. , The link between persistent ... so-called high-grade prostate cancer those with a Gleason ... of the most aggressive and rapidly growing prostate cancers. ...
(Date:4/17/2014)... new pain relief targets that could be used ... at King,s College London made the discovery when ... periphery of the body. , Dr Marzia Malcangio ... underlying pain generation and our findings could help ... , One potential side effect of some chemotherapy ...
(Date:4/17/2014)... published today in PLOS Pathogens , children who ... common can mount an immune response to infection with ... bouts of high fever and illness and partially control ... findings may help researchers develop future interventions that prevent ... , Each year, approximately 200 million cases of malaria ...
(Date:4/17/2014)... of California, San Diego School of Medicine report that ... a recent major loss are more likely to be ... study is published in this month,s issue of the ... compassionate behaviors are associated with better health and well-being ... ways to improve the outcomes of individuals whose deficits ...
(Date:4/17/2014)... review published in the April issue of Immunity ... Institute for Medical Research, says it,s time to take ... to treating sepsis, which kills millions worldwide every ... when molecules released into the bloodstream to fight an ... is necessary for maintaining good health without inflammation, ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:New pain relief targets discovered 2Health News:Study sheds light on how the immune system protects children from malaria 2Health News:The ilk of human kindness 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2
... 29, 2007 Traditionally, clinicians have relied on ... visits as the primary means of assessing patients ... could arise if important symptoms go unreported during ... A new study by researchers at Memorial Sloan-Kettering ...
... Nov. 29 Today, the Infectious,Diseases Institute (IDI) ... leader in HIV/AIDS prevention and treatment, as the ... joining IDI, Dr. Coutinho spent six years leading ... care and treatment,organization in Africa. His impressive accomplishments ...
... New MEDEX Global Group/Harvard Medical International Website goes beyond, ... the Lesser-Known Factors ... Healthcare, BALTIMORE, Nov. 29 Determining health risks ... incredibly complex.,According to the just published MEDEX 360m International ...
... Nov. 29 AtriCure, Inc.,(Nasdaq: ATRC ), a ... announced today that David J. Drachman, President and,Chief Executive ... Markets,2007 Healthcare Conference at the Millennium Broadway Hotel in ... ET., A live web cast and recording of ...
... 29 Specialty chemicals,maker Albemarle Corporation (NYSE: ... (also referred to as DBM, methylene dibromide, or,MDB) ... 2007, or as contracts allow., (Logo: ... needed to cover higher costs, in particular,higher raw ...
... on seizures linked to lamotrigine use, research shows , ... levels of the drug lamotrigine in pregnant women with epilepsy ... research shows. , Lamotrigine, an epilepsy drug, is taken by ... of causing birth defects. However, the drug has also been ...
Cached Medicine News:Health News:Cancer patients may benefit from reporting symptoms online in real time 2Health News:Cancer patients may benefit from reporting symptoms online in real time 3Health News:Cancer patients may benefit from reporting symptoms online in real time 4Health News:Infectious Diseases Institute Appoints Alex Coutinho, M.D as Executive Director 2Health News:Infectious Diseases Institute Appoints Alex Coutinho, M.D as Executive Director 3Health News:MEDEX 360m Rates the State of Global Medical Care for Travelers 2Health News:AtriCure to Present at BMO Capital Markets 2007 Healthcare Conference 2Health News:Albemarle to Raise Prices of Dibromomethane 2Health News:Tracking Drug Levels Helps Pregnant Women With Epilepsy 2
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across the ... select Meijer pharmacies in Michigan will ... eligible patients, enabling Meijer pharmacists to administer tests and, in ... by a physician participating in the study. The ...
(Date:1/15/2014)... 2014 Shire plc (LSE: SHP, NASDAQ: ... Trading (OFT) approval condition to the announced tender offer for all ... As a result of the waiver, the transaction is no ... tender offer on January 24, 2014 following the currently scheduled expiration ...
(Date:1/15/2014)... 2014 Tegra Medical is very pleased to announce the ... new Chief Executive Officer.  Mark was promoted from his current ... the company,s four facilities in Massachusetts , ... joined Tegra Medical in 2012 with 20+ years of broad-based ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... Cardiovascular Patch utilizes advanced fluoropolymer ... around penetrating suture and decrease ... much as 88 percent. This ... retention, multi-directional strength and low ...
... surgery, modified Blalock-Taussig shunts provide palliation of ... GORE-TEX Vascular Grafts configured for Pediatric Shunts ... use as shunts in pediatric cardiac procedures. ... ease of implantation and take-down at total ...
... techniques for vascular surgery, and the accompanying ... specialized types of graft be developed. Grafts ... biocompatible, but also available in varying sizes ... Vascular Graft has long been the prosthetic ...
... have met the challenges of the most ... Recognized for exceptional performance and quality, they ... worldwide. These grafts require no preclotting, resist ... assure utmost thrombectomy safety. Gore vascular grafts ...
Medicine Products: