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Seizure drug enhances sleep for women with hot flashes

Date:9/8/2009

Gabapentin, a drug initially used to treat seizures, improves sleep quality in menopausal women with hot flashes, University of Rochester Medical Center researchers report online and in the September issue of the Journal of Women's Health.

Approximately 40 percent of menopausal women experience sleep disruption, often in the form of difficulty with sleep initiation and frequent nighttime awakenings. The study is the first to show sustained benefits in sleep quality from gabapentin, which Rochester researchers already have demonstrated alleviates hot flashes.

"Gabapentin improves sleep quality but does not have the potential dependency problems of some other sleep medications and does not involve the use of hormone replacement therapy," said Michael E. Yurcheshen, M.D., assistant professor of Neurology and the lead author of the article.

"It has minimal side effects and it is a generic drug," said Yurcheshen, who is based at the Strong Sleep Disorders Center. "That makes it a very attractive treatment for these problems in this patient population."

For the current study, researchers used data from a previously published randomized, double-blind, placebo-controlled trial of gabapentin in 59 postmenopausal women who experienced seven to 20 hot flashes daily. The subjects took either 300 milligrams of gabapentin three times a day or a placebo.

The research used a factor analysis of the Pittsburgh Sleep Quality Index, a well-known and validated questionnaire, to evaluate sleep. The results showed overall improvement in the sleep quality score, even after 12 weeks of treatment.

Gabapentin's impact on the sleep quality factor in menopausal women may reflect improvement in hot flashes, stabilization of sleep architecture, or a decrease in the amount of time to transition from wakefulness to sleep, the researchers wrote. It is also possible that gabapentin improved sleep quality by addressing underlying sleep
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Contact: Michael Wentzel
Michael_Wentzel@urmc.rochester.edu
585-275-1309
University of Rochester Medical Center
Source:Eurekalert

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