Navigation Links
Seizure Meds Can Be Safely Withdrawn From Kids With Epilepsy

Study finds relatively low risk of developing intractable disease

MONDAY, Dec. 8 (HealthDay News) -- It's generally safe to stop giving anti-seizure medication to children with epilepsy who've achieved seizure-freedom while on the medication, because these children aren't at high risk of later developing intractable epilepsy, a Mayo Clinic study finds.

Intractable epilepsy, which affects about 10 percent of children with epilepsy, is a condition in which medications alone don't control seizures and in which seizures have a disabling effect on the patient's quality of life.

"It is often recommended that children with epilepsy who become seizure-free on anti-seizure medications be withdrawn from the drugs to avoid side effects of long-term use. Those potential side effects include cognitive slowing, incoordination, weight change, behavioral decline, and liver damage," pediatric neurologist Dr. Katherine Nickels said in a Mayo news release. "However, few previous studies had examined the risk of intractable epilepsy following withdrawal of anti-seizure medication, and the reported risks varied widely."

In this study, Nickels and colleagues reviewed the records of 152 children, ages 1 month to 16 years, who were diagnosed with new-onset epilepsy between 1990 and 2000 and treated with anti-seizure medication. Of those children, 56 (37) percent achieved seizure-freedom and were taken off their medication.

After an average follow-up of eight years, 20 of the 56 children experienced at least one seizure recurrence. Fifteen of those 20 children re-started treatment with anti-seizure medication. Eight of those 15 achieved seizure-freedom within one year, two achieved seizure-freedom after two years, and three developed intractable epilepsy. Overall, intractable epilepsy developed in 5 percent of the 56 children who were taken off anti-seizure medication following seizure-freedom, the study found.

"The risk of children developing intractable epilepsy after withdrawal of anti-seizure medication was only five percent, which is similar to the risk of intractable epilepsy at the time of initial diagnosis of epilepsy in children," Nickels said. "Therefore, the children who achieve seizure-freedom on anti-seizure medication should be considered for withdrawal without high risk of intractable epilepsy."

The study was to be presented Dec. 7 in Seattle at the annual meeting of the American Epilepsy Society.

More information

The Epilepsy Foundation has more about epilepsy.

-- Robert Preidt

SOURCE: Mayo Clinic, news release, Dec. 7, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Mayo Clinic finds it generally safe to withdraw anti-seizure medication in children with epilepsy
2. New target discovered to treat epileptic seizures following brain trauma or stroke
3. Clue to Cause of Epileptic Seizures Discovered
4. LegalView Informs Chantix Patients of Risk of Seizures Leading to Traffic Accidents
5. Keppra XR(TM) Offers Convenient Dosing For People With Partial Onset Seizures
6. NIAID media availability: Seizures following parasitic infection associated with brain swelling
7. Sedative Could Be Deadly in People With Seizures
8. Antiseizure Drug Could be Fatal
9. Anti-seizure drug could be fatal
10. Seizures in newborns can be detected with small, portable brain activity monitors
11. Failure to Take Seizure Drugs Boosts Death Risk
Post Your Comments:
Related Image:
Seizure Meds Can Be Safely Withdrawn From Kids With Epilepsy
(Date:11/24/2015)... , ... November 24, 2015 , ... Aided by seed ... announced an innovative study designed to yield insights into how to detect and treat ... biomarkers for pancreatic cancer from small, non-coding RNA molecules (ncRNA), genetic material that is ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Rodney E. Willey , has answered a ... Koala Center for Sleep Disorders, provides treatment for snoring and sleep apnea through ... a Koala Center for Sleep Disorders in the US, one of four in the Illinois ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Autism Speaks, ... the global movement driven by social media and the generosity of people around the ... encourage their social media networks to give – and share the personal stories behind ...
(Date:11/24/2015)... Tennessee (PRWEB) , ... November 24, 2015 , ... ... Pharmacy Quality Trend Report . Throughout the past year there have been multiple breakthroughs ... mature state. During this transition, PharmMD has enabled their customers and partners to stay ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... “I am so thrilled, as a newbie ... after learning she had won a $7,500 School Lounge Makeover® from California Casualty . ... most of the staff has a much longer tenure. , “This is such an amazing ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... --> --> ... by Product Type (Bone Graft, Bine Graft Substitute, Platelet Rich ... Lumbar Interbody Fusion), End User, and Geography - Global Forecast ... at $1.90 Billion in 2014 and is expected to reach ... the forecast period of 2015 to 2020. Browse ...
(Date:11/24/2015)... BERN, Switzerland , November 24, 2015 ... for Biomedical Engineering Research of the University of ... Endocrinology, Diabetes and Clinical Nutrition of the Bern University ... an exclusive collaboration to develop a novel generation artificial ... personalised delivery of insulin for diabetic patients with the ...
(Date:11/24/2015)... 2015 st  Scientific Assembly and Annual Meeting ... (RSNA) taking place in Chicago on Nov-29 ... --> st  Scientific Assembly and Annual Meeting of the ... place in Chicago on Nov-29 th ... Molecular Dynamics will present its revolutionary whole body CZT digital ...
Breaking Medicine Technology: