Navigation Links
Seeing through HIV's disguises
Date:2/27/2013

Studying HIV-1, the most common and infectious HIV subtype, Johns Hopkins scientists have identified 25 human proteins "stolen" by the virus that may be critical to its ability to infect new cells. HIV-1 viruses capture many human proteins from the cells they infect but the researchers believe these 25 proteins may be particularly important because they are found in HIV-1 viruses coming from two very different types of infected cells. A report on the discovery, published online in the Journal of Proteome Research on Feb. 22, could help in building diagnostic tools and novel treatment strategies to fight HIV infection.

When a new HIV particle emerges from an infected human cell, it wraps itself in membrane and proteins from the host cell, effectively disguising itself from the immune system's sentinels. Scientists believe that some of these proteins are specifically "chosen" by the virus in order to enhance its ability to survive, while other proteins may be just randomly caught up in the viral packaging.

"Human proteins incorporated into viruses could potentially be used to find, and selectively kill, cells harboring HIV, but the problem is that HIV can steal hundreds of different proteins unique to each cell type that it infects, leaving too many targets for researchers and drug companies to chase after," according to David Graham, Ph.D., the senior author of the study report and assistant professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. The new research, he says, narrows the target pool to a small number of proteins that may be most important for HIV infection and survival.

HIV infects several types of cells throughout the body, most notably CD4+ T-cells and macrophages, both major parts of the immune system. Graham and his team suspected that a comparison of human proteins incorporated into HIV particles from different cell types could lead them to the human proteins important to the virus' disease activity.

After isolating HIV-1 particles from lab-grown human CD4+ T-cells, Graham and his team used powerful protein sequencing and bioinformatics tools to identify all of the associated human proteins. They then used the same bioinformatics tools to re-analyze protein content information from HIV-1 particles isolated from lab-grown human macrophages, data previously published by another group of researchers.

With the help of sophisticated computing, the team identified 279 proteins taken up by HIV-1 particles from one or the other cell type. Of these, only 25 were shared by viruses from both cell types.

One protein the research team identified that could be particularly important to diagnosis and treatment is CD44, because it appears to be the only one of the 25 capable of binding to other cells. It helps the viruses attach themselves to sites of inflammation. Graham suggests that "this makes a lot of sense for a virus that likes to infect T-cells and macrophages because both types of cells migrate to sites of inflammation to help out. Little do they know that HIV viruses are lying in wait."


'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Related medicine news :

1. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
2. Seeing fewer older people in the street may lead low-income adults to fast-track their lives
3. Promising breakthrough for transplant patients
4. Vermaland, LLC. Sees Land Sale Market Improvements and Predicts Demand Increases Throughout the Year
5. Infrared digital holography allows firefighters to see through flames, image moving people
6. Breakthrough camera to improve detection of blinding eye disease and diabetes
7. Camp Good Days Helps Kids with Cancer through E-Scrap for Camp Fundraising Drive, VoIP Supply Hosts Collection Site
8. truDERMA™ Launches Troxyphen, Breakthrough Weight Loss Supplement for Men
9. Dr. Lewis Cantley awarded $3 million breakthrough prize in life sciences
10. Fourth Annual Georgia Partnership for Telehealth, Inc. Conference, Impacting Lives Through Applied Technology, to be held March 18-20th 2013 in Savannah, Georgia
11. Aspen Becomes a Premier CHIME Foundation Member and Supports Vision to Shape the Future of Healthcare through IT Leadership
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Seeing through HIV's disguises
(Date:12/7/2016)... ... December 07, 2016 , ... They are musicians and librarians, fashion ... brothers and fathers, from New England and around the nation. What do they have ... brought together in a beautiful and compelling new photographic exhibit debuting Friday, December 9 ...
(Date:12/7/2016)... TX (PRWEB) , ... December 07, 2016 , ... ... offering insurance and financial planning services to families and business owners in the ... funds on behalf of the Dallas Fallen Officer Foundation. , Established in 2009 ...
(Date:12/7/2016)... ... 07, 2016 , ... Sharon Kleyne, host of the nationally syndicated radio program, ... Voice of America, declared on her radio program in November 2016 the need to ... these bullies attack leaders in corporate America, they are trying to take advantage of ...
(Date:12/7/2016)... TX (PRWEB) , ... December 07, 2016 , ... ... 2016 Top 20 Marketing Campaign Winner in the Folio: Marketing Awards competition. Live ... recognize the year’s best in pioneering, inventive, and ultimately successful projects undertaken by ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... (IFW) Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 ... of three acupuncturists to help patients realize their family building goals. Acupuncture ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7,2016  Based on ... delivery industry, Frost & Sullivan recognizes Nemaura ... & Sullivan Award for Enabling Technology Leadership. ... the loopholes in traditional drug delivery technologies, ... liquid microneedle-based drug delivery technologies, Memspatch and ...
(Date:12/7/2016)... , December 7, 2016 According ... Research titled , Global Market Study on Multiplex Detection Immunoassay: ... , the global multiplex detection immunoassay market is expected to ... 2016-2024. ... ,      ...
(Date:12/6/2016)... Mass. , Dec. 6, 2016  Alopexx Oncology, ... DI-Leu16-IL2, a recombinant antibody fusion protein (immunocytokine) composed of ... recognizes the same target on B cells as Rituxan ... cytokine components but is also involved in tumor targeting, ... anti-cancer vaccine effect. The results of the study (abstract ...
Breaking Medicine Technology: