Navigation Links
Seeing through HIV's disguises
Date:2/27/2013

Studying HIV-1, the most common and infectious HIV subtype, Johns Hopkins scientists have identified 25 human proteins "stolen" by the virus that may be critical to its ability to infect new cells. HIV-1 viruses capture many human proteins from the cells they infect but the researchers believe these 25 proteins may be particularly important because they are found in HIV-1 viruses coming from two very different types of infected cells. A report on the discovery, published online in the Journal of Proteome Research on Feb. 22, could help in building diagnostic tools and novel treatment strategies to fight HIV infection.

When a new HIV particle emerges from an infected human cell, it wraps itself in membrane and proteins from the host cell, effectively disguising itself from the immune system's sentinels. Scientists believe that some of these proteins are specifically "chosen" by the virus in order to enhance its ability to survive, while other proteins may be just randomly caught up in the viral packaging.

"Human proteins incorporated into viruses could potentially be used to find, and selectively kill, cells harboring HIV, but the problem is that HIV can steal hundreds of different proteins unique to each cell type that it infects, leaving too many targets for researchers and drug companies to chase after," according to David Graham, Ph.D., the senior author of the study report and assistant professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. The new research, he says, narrows the target pool to a small number of proteins that may be most important for HIV infection and survival.

HIV infects several types of cells throughout the body, most notably CD4+ T-cells and macrophages, both major parts of the immune system. Graham and his team suspected that a comparison of human proteins incorporated into HIV particles from different cell types could lead them to the human protei
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
2. Seeing fewer older people in the street may lead low-income adults to fast-track their lives
3. Promising breakthrough for transplant patients
4. Vermaland, LLC. Sees Land Sale Market Improvements and Predicts Demand Increases Throughout the Year
5. Infrared digital holography allows firefighters to see through flames, image moving people
6. Breakthrough camera to improve detection of blinding eye disease and diabetes
7. Camp Good Days Helps Kids with Cancer through E-Scrap for Camp Fundraising Drive, VoIP Supply Hosts Collection Site
8. truDERMA™ Launches Troxyphen, Breakthrough Weight Loss Supplement for Men
9. Dr. Lewis Cantley awarded $3 million breakthrough prize in life sciences
10. Fourth Annual Georgia Partnership for Telehealth, Inc. Conference, Impacting Lives Through Applied Technology, to be held March 18-20th 2013 in Savannah, Georgia
11. Aspen Becomes a Premier CHIME Foundation Member and Supports Vision to Shape the Future of Healthcare through IT Leadership
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Seeing through HIV's disguises
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... In an ... are hospitalized, Dr. Aggarwal is making a change in his practice. , The decision ... Effective August 14, 2015, Dr. Aggarwal will be transferring his in-patient admissions to the ...
(Date:7/30/2015)... Miami, FL (PRWEB) , ... July 30, 2015 ... ... a new online program entitled " Lovetraction Lines ." It's for women interested ... in the men they desire. The course, which officially launched to the public ...
(Date:7/30/2015)... CATHERAL CITY, California (PRWEB) , ... July 30, 2015 , ... ... of substance abuse, clients at Serenity Palms Drug Addiction Treatment Center have created an ... Springs just lost one of its most beloved residents, Rocky Hudson . Hudson ...
(Date:7/30/2015)... ... July 30, 2015 , ... Mullin/Ashley Associates, ... of three awards in the Service Industry Advertising Awards 12th annual national competition. ... KRM Development Corporation and University of Maryland Shore Regional Health. , A Gold ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... Google recently ... an upcoming dedicated web site. As discussed in a June 8, 2015 article published ... collisions reported so far have been caused by its computer-driven cars, which such industry ...
Breaking Medicine News(10 mins):Health News:River Valley Physician Dr. Aggarwal is Making Changes to his Practice 2Health News:Lovetraction Lines - Review Examining Simone Myers' New Online Course Released 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 3Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 2Health News:New Google Policy on Reporting Driverless Auto Accidents Points Out Growing Complexity of Personal Injury Law in the 21st Century, Says Law Offices of Burg and Brock 3
... , OWINGS MILLS, Md., July 23 Medifast, Inc. (NYSE: ... 2009 financial results for the period ended June 30, 2009 on Thursday, July ... a conference call and web cast to discuss the results on Thursday, July ... Interested parties can access the call by dialing (877) 407-0782 or (201) 689-8567, ...
... Gentiva Health Services, Inc. (Nasdaq: GTIV ), a ... has signed a definitive agreement to purchase Magna Home Health, a ... west central Alabama. Both states require a certificate of need (CON) ... , With the addition of Magna,s ...
... WILMINGTON, Del., July 23 AstraZeneca (NYSE: ... program by immediately extending assistance to qualifying patients who have ... a change in marital status or family size. , ... change in income or family size had difficulty applying to ...
... , , ... world,s leading research and advisory firms focusing on pharmaceutical and ... Abilify has grown in the first three lines of therapy ... schizophrenia patients. Abilify is second to risperidone (Janssen,s Risperdal, generics) ...
... , , , ... Fighters (IAFF) and Masimo jointly announced the launch of a new international ... dangers of carbon monoxide (CO) and reducing known risk factors that unnecessarily ... kicked off at the biennial IAFF EMS Conference in Miami Beach, Florida, ...
... , , CHARLOTTE, N.C., July 23 MedCath Corporation (Nasdaq: ... to discuss results from its third quarter ended June 30, 2009. The company will issue a ... What: Third Quarter Earnings Conference ... 2009, How: Dial-in conference call, ...
Cached Medicine News:Health News:Medifast, Inc. to Announce Second Quarter Fiscal Year 2009 Financial Results on Thursday, July 30, 2009 2Health News:Gentiva(R) Health Services Signs Agreement to Acquire Home Health Agency with Offices in Mississippi and Alabama 2Health News:Gentiva(R) Health Services Signs Agreement to Acquire Home Health Agency with Offices in Mississippi and Alabama 3Health News:AstraZeneca Expands Prescription Savings Program 2Health News:Abilify Has Made Strong Gains in Patient Share Across All Lines of Therapy Since Last Year's Analysis of Prescribing Trends in Schizophrenia 2Health News:Abilify Has Made Strong Gains in Patient Share Across All Lines of Therapy Since Last Year's Analysis of Prescribing Trends in Schizophrenia 3Health News:The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters 2Health News:The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters 3Health News:The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters 4Health News:The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters 5Health News:The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters 6Health News:MedCath Corporation to Hold Conference Call on Third Quarter Results 2
(Date:7/30/2015)... , July 30, 2015  ResMed (NYSE: ... signed a definitive agreement to acquire Curative ... ventilation and sleep-disordered breathing medical devices and ... market reputation in China, combined with ResMed,s global leadership in sleep and ... China suffering from ...
(Date:7/30/2015)... bring you a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As ... resources and continue highlighting the success of the prescription drug benefit, commonly referred to ... our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... THOUSAND OAKS, Calif. , July 30, 2015  Amgen ... Fred Hassan , partner and managing director of Warburg Pincus ... "We are pleased to welcome Fred Hassan and ... to the Amgen Board," said Robert A. Bradway , ... expertise and commitment to innovation will serve Amgen well." ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3
... Osteotech, Inc. (Nasdaq: OSTE ), a ... regenerative healing, announced today that its patent supporting the ... the Research and Development Council of New Jersey,s 31st ...  Osteotech was chosen from a broad field of nominees ...
... Dendreon Corporation (Nasdaq: DNDN ) today reported ... the third quarter ended September 30, 2010 was $20.2 million ... Revenue for the nine months ended September 30, 2010 was ... September 30, 2009.   Revenue from sales of ...
Cached Medicine Technology:Osteotech's Plexur M® Technology Wins Thomas Alva Edison Patent Award from the New Jersey Research and Development Council 2Osteotech's Plexur M® Technology Wins Thomas Alva Edison Patent Award from the New Jersey Research and Development Council 3Dendreon Reports Third Quarter 2010 Financial Results 2Dendreon Reports Third Quarter 2010 Financial Results 3Dendreon Reports Third Quarter 2010 Financial Results 4
Auto Refkeratomoeter...
... The InfusO.R. Pump is a ... aid in the administration of ... anesthetic procedures. It provides for ... muscle relaxants, and vasoactive drugs ...
Developed to meet the infusion needs in NICU, Anesthesia and Critical Care, the AUTO SYRINGE AS50 Infusion Pump delivers precise, controlled infusions....
Pain management can be complicated. But that doesn't mean your PCA infusion system should be. The new SYNDEO PCA Syringe Pump streamlines pain therapy with a powerful combination of intelligent desig...
Medicine Products: