Navigation Links
Seeing through HIV's disguises
Date:2/27/2013

Studying HIV-1, the most common and infectious HIV subtype, Johns Hopkins scientists have identified 25 human proteins "stolen" by the virus that may be critical to its ability to infect new cells. HIV-1 viruses capture many human proteins from the cells they infect but the researchers believe these 25 proteins may be particularly important because they are found in HIV-1 viruses coming from two very different types of infected cells. A report on the discovery, published online in the Journal of Proteome Research on Feb. 22, could help in building diagnostic tools and novel treatment strategies to fight HIV infection.

When a new HIV particle emerges from an infected human cell, it wraps itself in membrane and proteins from the host cell, effectively disguising itself from the immune system's sentinels. Scientists believe that some of these proteins are specifically "chosen" by the virus in order to enhance its ability to survive, while other proteins may be just randomly caught up in the viral packaging.

"Human proteins incorporated into viruses could potentially be used to find, and selectively kill, cells harboring HIV, but the problem is that HIV can steal hundreds of different proteins unique to each cell type that it infects, leaving too many targets for researchers and drug companies to chase after," according to David Graham, Ph.D., the senior author of the study report and assistant professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. The new research, he says, narrows the target pool to a small number of proteins that may be most important for HIV infection and survival.

HIV infects several types of cells throughout the body, most notably CD4+ T-cells and macrophages, both major parts of the immune system. Graham and his team suspected that a comparison of human proteins incorporated into HIV particles from different cell types could lead them to the human proteins important to the virus' disease activity.

After isolating HIV-1 particles from lab-grown human CD4+ T-cells, Graham and his team used powerful protein sequencing and bioinformatics tools to identify all of the associated human proteins. They then used the same bioinformatics tools to re-analyze protein content information from HIV-1 particles isolated from lab-grown human macrophages, data previously published by another group of researchers.

With the help of sophisticated computing, the team identified 279 proteins taken up by HIV-1 particles from one or the other cell type. Of these, only 25 were shared by viruses from both cell types.

One protein the research team identified that could be particularly important to diagnosis and treatment is CD44, because it appears to be the only one of the 25 capable of binding to other cells. It helps the viruses attach themselves to sites of inflammation. Graham suggests that "this makes a lot of sense for a virus that likes to infect T-cells and macrophages because both types of cells migrate to sites of inflammation to help out. Little do they know that HIV viruses are lying in wait."


'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Related medicine news :

1. Seeing is believing: Biologists and physicists produce revealing images of cell organization, behavior
2. Seeing fewer older people in the street may lead low-income adults to fast-track their lives
3. Promising breakthrough for transplant patients
4. Vermaland, LLC. Sees Land Sale Market Improvements and Predicts Demand Increases Throughout the Year
5. Infrared digital holography allows firefighters to see through flames, image moving people
6. Breakthrough camera to improve detection of blinding eye disease and diabetes
7. Camp Good Days Helps Kids with Cancer through E-Scrap for Camp Fundraising Drive, VoIP Supply Hosts Collection Site
8. truDERMA™ Launches Troxyphen, Breakthrough Weight Loss Supplement for Men
9. Dr. Lewis Cantley awarded $3 million breakthrough prize in life sciences
10. Fourth Annual Georgia Partnership for Telehealth, Inc. Conference, Impacting Lives Through Applied Technology, to be held March 18-20th 2013 in Savannah, Georgia
11. Aspen Becomes a Premier CHIME Foundation Member and Supports Vision to Shape the Future of Healthcare through IT Leadership
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Seeing through HIV's disguises
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart Holdings, Inc. announced ... with the tools and information to lower the costs, and increase the impact ... of providing employee healthcare benefits by as much as 22%:, + Price ...
(Date:2/6/2016)... ... February 06, 2016 , ... ... PERIOPERATIVE NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT:     , ... with an estimated 5000 perioperative nurses in attendance to study the latest ...
(Date:2/6/2016)... , ... February 06, 2016 , ... With the ... add warm color grades to their footage. A LUT is a Lookup Table that ... to the corresponding color indicated by the table. By manipulating each pixel, LUT's can ...
(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... ... phases of eating disorder treatment helps to reduce the frequency and level of ... the Recovery Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks ...
(Date:2/5/2016)... NY (PRWEB) , ... February 05, 2016 , ... Love ... long-stem roses in a variety of colors, assortments and packaging. This staple for Valentine’s ... any King Kullen location. , For Valentine’s Day, not only are long-stem roses ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)...   Bernstein Liebhard LLP today announced that a ... District Court for the District of Arizona ... all persons or entities who purchased common shares of Insys ... from March 3, 2015 through January 25, 2016 (the "Class ... with violations of the Securities Exchange Act of 1934.  ...
(Date:2/4/2016)... 2016  Montoya Love is recognized by Continental Who,s ... Pharmaceuticals. Montoya is the Regulatory Systems Operations Manager with ... Manufacturing and selling a broad range ... provides healthcare institutions, clinical laboratories and life science researchers ... the globe. ...
(Date:2/4/2016)... -- Frontier Pharma: Chronic Obstructive Pulmonary Disease (COPD) ... Chronic Obstructive Pulmonary Disease (COPD) is a ... airways and lungs. Persistent breathing difficulties and repeated ... of the leading causes of morbidity and the ... is linked to cumulative exposure to risk factors, ...
Breaking Medicine Technology: