Navigation Links
See-through 'MitoFish' opens a new window on brain diseases
Date:12/5/2012

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see within individual neurons of living animals how brain diseases disturb the transport of mitochondria, the power plants of the cell.

Neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS (amyotrophic lateral sclerosis), and MS (multiple sclerosis) are quite different in their effects on patients' cognitive and motor functions, behavior, and prognosis. Yet on the level of individual neurons, common mechanisms can be observed that either cause or accompany nerve degeneration in a number of different diseases. One of these is a disturbance in the transport of mitochondria, organelles that play several vital roles in the life of a cell above all, delivering energy where it is needed. And in a neuron, an extremely power-hungry cell, that means moving mitochondria all the way down its longest extension, the axon. Studying mitochondria transport in other animal models of neurodegenerative disease, particularly in mice, has been revealing. But the MitoFish model opens up new possibilities.

The new model was jointly developed in the labs of Prof. Thomas Misgeld of the Technische Universitt Mnchen (TUM) and Dr. Bettina Schmid, a senior scientist of the German Center for Neurodegenerative Diseases (DZNE) based at the institute of LMU Prof. Christian Haass. "This collaboration has provided a system," Misgeld says, "with which we can try to understand the traffic rules or the life cycle of a given organelle, in this case mitochondria, in the context of a nerve cell that's existing in its physiological environment, where it is developing and changing. Most of these t
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-089-289-10515
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Cancer therapy -- Nanokey opens tumors to attack
2. McDivitt Law Firm Opens Office to Fellow Attorneys Affected by Colorado Springs Wildfires
3. Tracy, California Coast Dental Office Opens
4. 101 Mobility Opens Franchise in Roanoke/Lynchburg Market
5. Novel Natural Sciences Repository Opens Web Portal
6. Experimental drug may extend therapeutic window for stroke
7. GSW Telnet Server for Windows Partners with MobileDemand
8. The first day of development -- a window to successful pregnancy
9. In US first, Johns Hopkins surgeons implant brain pacemaker for Alzheimers disease
10. The radical restructuring of brain networks in comatose patients
11. Barrow researchers successfully destroy brain tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
See-through 'MitoFish' opens a new window on brain diseases
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... City, Florida (PRWEB) January 22, 2015 IsoComforter, ... cold therapy machine with patented IsoTube design to treat specific ... has introduced the most progressive and easy to use patented ... treat post-operative and sports related orthopedic and muscle injuries. ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
(Date:1/22/2015)... has released a new blog post presenting a list of vehicles ... , Some types of vehicles cannot be covered under an ... post to see if their vehicle qualifies for auto insurance coverage. ... the cars that cannot be covered by a plan. Clients have ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 State Forestry ... data management system with support from GEOSYSTEMS, a dedicated ... new solution will leverage Hexagon Geospatial’s ERDAS APOLLO ... data as well as point clouds and documents. This ...
Breaking Medicine News(10 mins):Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... countries will share ideas on manufacturing techniques for ... industry sectors at the third International Conference On ... , Burak O. Ozdoganlar, ICOMM,08 chair and ... at Carnegie Mellon, said the conference is a ...
... First year college students believe that occasional nonmedical use ... than cocaine, but more risky than marijuana or consuming ... a new study published in the September issue of ... Society for Prevention Research., This is the first study ...
... Sept. 2 A sudden sharp increase in ... concern for parents and,healthcare professionals. Here,s more on ... Listen to this report from Nationwide Children,s Hospital ... video, audio, text, graphics and,photos for free and ...
... Award-winning online program helps schools better comply with federal ... health issues, LANCASTER, Pa., Sept. 2 For ... could be lower than our own. The,Centers for Disease ... prevalence of overweight and obesity has increased,sharply for both ...
... Costs and ... Improve Patient Outcomes Together, HOUSTON, Sept. 2 US ... division that offers a first-time,opportunity for oncologists and health plans ... of cancer,care. With a unique focus on supporting the entire ...
... took benefit of nation,s 1st such law, passed in 2004 ... chronically ill kids have made use of California,s pioneering paid ... aware it exists, according to researchers at the Rand Corp. ... leave law. It is funded by employees through an automatic ...
Cached Medicine News:Health News:Carnegie Mellon to host micromanufacturing conference 2Health News:College freshmen: pain killers and stimulants less risky than cocaine; more risky than marijuana 2Health News:Highmark Foundation Extends Subsidy for Health eTools for Schools(R) through 2013 2Health News:Highmark Foundation Extends Subsidy for Health eTools for Schools(R) through 2013 3Health News:Highmark Foundation Extends Subsidy for Health eTools for Schools(R) through 2013 4Health News:Highmark Foundation Extends Subsidy for Health eTools for Schools(R) through 2013 5Health News:Highmark Foundation Extends Subsidy for Health eTools for Schools(R) through 2013 6Health News:US Oncology Launches New Services Division: Innovent Oncology 2Health News:US Oncology Launches New Services Division: Innovent Oncology 3Health News:US Oncology Launches New Services Division: Innovent Oncology 4Health News:Paid Family Leave Program Goes Mostly Unused 2
(Date:1/23/2015)... (NYSE: MNK ) announced today that its ... The open-ended authorization permits the company to repurchase up ... "Funding additional initiatives and seeking attractive business ... pursue a range of focused growth strategies," said ...
(Date:1/23/2015)... LONDON and BOSTON , January ... structure-guided drug discovery and development company, is delighted to announce ... has been awarded to Miles Congreve (Vice President ... co-founder) and Malcolm Weir (Chief Executive Officer and ...
(Date:1/22/2015)... 2015  ViewRay™, a privately held medical device company, announced ... agreement with ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) ... treatment of cancer in Japan . ... first and only MRI-guided radiation therapy system that images ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... 2011 VWR Funding, Inc., the parent company ... supply and distribution company, will hold a conference ... its first quarter 2011 financial results. ... President and CEOGregory L. Cowan , Senior Vice ...
... 6, 2011 SaveRxCanada.com the premier Canadian pharmacy intermediary ... Canada drugs from a Canada pharmacy . ... drugs can be 85% less than the U.S. price and ... 2002. 2. Convenience – Many patients are elderly and ...
Cached Medicine Technology:VWR to Hold First Quarter 2011 Financial Results Conference Call 2Canadian Pharmacy Intermediary's Top Reasons U.S. Customers Choose Canada Online Pharmacies Revealed by SaveRxCanada.com 2
VascoTip is a unipolar tined permanent pacing lead. Due to advanced technology, VascoTip 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm), 5 mm, 6 mm....
VascoTwist is a low profile unipolar permanent pacing lead with a retractable screw. Due to advanced technology VascoTwist 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm...
VascoTwist is a low profile unipolar permanent pacing lead with a retractable screw. Due to advanced technology VascoTwist 9/60 M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm...
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
Medicine Products: