Navigation Links
Sedative Could Be Deadly in People With Seizures
Date:10/28/2008

At high doses, propofol tied to cardiac arrest in patients with a form of epilepsy

TUESDAY, Oct. 28 (HealthDay News) -- Use of the sedative propofol is associated with a high risk for complications and even death in patients with prolonged seizures, according to a study by researchers at the Mayo Clinic in Rochester, Minn.

The study included 39 patients with refractory status epilepticus (RSE) -- prolonged seizures that don't respond to initial treatment. The condition occurs in patients with primary epilepsy and in those with other conditions such as trauma, tumors and infections that affect the brain.

Propofol is used to treat patients with RSE, but is more commonly used for sedation during surgery or other patient procedures. In those situations, propofol is used at a much lower dose and shorter duration than when it's used to treat RSE, according to background information in an American College of Chest Physicians news release on the Mayo study.

"Patients with RSE treated with propofol are at high risk for propofol-related side effects because of the high propofol infusion rates and prolonged treatment duration necessary in these patients. However, it is well described that propofol toxicity can occur even with brief exposure to the drug," study author Dr. Vivek Iyer, of the Mayo Clinic, said in the news release.

In the study, 39 patients (average age 54) were admitted to the intensive care unit with RSE. Thirty-two received propofol for a median of 63 hours and a median peak infusion rate of 67 micrograms per kilogram per minute. The other seven patients received other drugs, such as midazolam and pentobarbital.

In the propofol group, three patients had sudden unexplained cardiac arrest, resulting in two deaths. There were no deaths in the other group.

Thirty percent of patients in the propofol group experienced propofol infusion syndrome (PRIS), a serious complication defined b
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Newer Sedative Might Help Patients on Ventilators
2. A high-fat diet could promote the development of Alzheimers
3. Antiseizure Drug Could be Fatal
4. Anti-seizure drug could be fatal
5. Common epilepsy drug could prevent and treat Alzheimers disease
6. The Pink Ribbon That Could Save Your Life
7. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
8. New Advances Could Battle Cancer Cell by Cell
9. Mayo Clinic estimates new, tiny, super-sensitive probe could cut colon polyp removal in half
10. New test could help catch serious infections in babies
11. New way to control protein activity could lead to cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sedative Could Be Deadly in People With Seizures
(Date:8/20/2014)... Missouri federal judge has remanded a lawsuit filed by a ... NaturaLyte to the City of St. Louis Circuit Court, reports ... rejected an assertion by the defendants that the plaintiffs’ claims ... v. Fresenius Medical Care North America Inc., et al., No. ... of the dialysis products GranuFlo and NaturaLyte. In 2012, the ...
(Date:8/20/2014)... News) -- Leaving the car at home and getting to ... your health, a new study indicates. Researchers looked at ... 76 percent of men and 72 percent of women drove ... women used public transit, and 14 percent of men and ... drove to work weighed more and had higher levels of ...
(Date:8/20/2014)... The Workgroup for Electronic Data Interchange ... use of health IT to create efficiencies in ... its annual fall conference, WEDI-Con 2014: The Next ... take place at the HYATT Regency in Reston, ... cross-section of payers, providers, government regulators, industry vendors ...
(Date:8/20/2014)... WI (PRWEB) August 20, 2014 Parents ... While the transition from summer months means buying textbooks ... element that is often a forgotten part of the ... , According to the American Psychological Association, 27% of ... year. Nearly half (45%) say they are stressed by ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Verndale is ... Inc. 500|5000 list; an exclusive list ranking the fastest-growing ... are ranked according to their yearly percentage revenue growth ... 8th time on the Inc. 5000 list where it ... Company, Verndale offers its clients a wide range of ...
Breaking Medicine News(10 mins):Health News:GranuFlo/NaturaLyte Case Remanded to State Court By Missouri Federal Judge, Baron and Budd Reports 2Health News:Want to Stay Slim? Leave the Car at Home 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 3Health News:Five Easy Steps to Help Your Child Manage Back-to-school Stress 2Health News:Five Easy Steps to Help Your Child Manage Back-to-school Stress 3Health News:For the 8th Time, Verndale Has Been Honored on the Inc. 5000 List 2
... Simple exercise routines can improve lung function and overall fitness ... a small new study suggest. Cystic fibrosis, or CF, ... mucus in the lungs, resulting in frequent lung infections, breathing ... regimens are difficult to adhere to long-term, so a team ...
... at The Scripps Research Institute have found a temperature-sensing protein within ... activate an immune response. This process can occur as temperature rises, ... immune cells are "called" from the body,s warm interior to a ... online ahead of print by Nature Chemical Biology , is ...
... FRIDAY, May 6 (HealthDay News) -- Nail salon workers may ... a new study warns. Researchers recruited 80 Vietnamese women ... their work-related exposure to toluene, ethyl acetate and isopropyl acetate. ... Journal of Public Health , showed that the workers were ...
... bacteria associated with exposure to livestock was recently discovered ... contact with livestock, according to University of Iowa researchers. ... study of Staphylococcus aureus in child day care facilities ... in the UI College of Public Health, for her ...
... Reinberg HealthDay Reporter , THURSDAY, May ... antibiotics can often cure appendicitis, surgery remains the ... appendicitis may be treated with antibiotics alone, but ... surgery, and it is difficult to discern between ...
... May 6 (HealthDay News) -- Americans walked and biked a ... new research finds. But the increases were minor, especially ... in the American Journal of Public Health . ... 2009 U.S. National Household Travel Surveys and found that the ...
Cached Medicine News:Health News:Everyday Exercise Can Help Kids With Cystic Fibrosis: Study 2Health News:Scripps Research scientists show how shifts in temperature prime immune response 2Health News:Scripps Research scientists show how shifts in temperature prime immune response 3Health News:Study finds livestock-related 'Staph' strain in child care worker 2Health News:Surgery May Beat Antibiotics for Appendicitis, Study Finds 2Health News:Surgery May Beat Antibiotics for Appendicitis, Study Finds 3Health News:Americans Walking, Biking a Bit More, Research Shows 2
(Date:8/20/2014)...   Ventana Medical Systems, Inc.  (Ventana), a ... its VENTANA System for Primary Diagnosis 1 ... for routine pathology, including primary diagnosis with human ... software coupled with either the VENTANA iScan Coreo ... automated digital slide creation, case management and computer ...
(Date:8/20/2014)... LAKE CITY , Aug. 20, 2014 ... revolutionary mobile diagnostic platform during a special event at ... Utah , on September 5, 2014. The event, ... LiveStreamed on the ApolloDx website, www.apollodx.com .    ... transform diagnostic testing," said Jared Bauer , Co-Founder ...
(Date:8/20/2014)... , Aug. 20, 2014 Trovagene, Inc. ... announced today that results from two clinical studies will ... for the Company,s urine-based diagnostic test for the detection ... IPV conference is scheduled to take place in ... to 25 th . Additionally, a new U.S. patent ...
Breaking Medicine Technology:Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 2Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 3Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3
... HeartWare International, Inc. (NASDAQ: HTWR ... miniaturized circulatory support technologies that are revolutionizing the treatment ... Godshall is scheduled to present at the Lazard Capital ... p.m. ET on Thursday, September 22, 2011.  The one-day ...
... and SEATTLE, Sept. 19, 2011 Varian ... Calypso Medical Technologies, Inc., today announced they have signed ... a privately-owned, Seattle-based developer and supplier of specialized products ... during radiosurgery and radiotherapy.  The acquisition, which is anticipated ...
Cached Medicine Technology:HeartWare to Present at The Lazard Capital Markets 3rd Annual Circulatory Assist Device Day 2Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 2Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 3Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 4Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: