Navigation Links
Sedative Could Be Deadly in People With Seizures
Date:10/28/2008

At high doses, propofol tied to cardiac arrest in patients with a form of epilepsy

TUESDAY, Oct. 28 (HealthDay News) -- Use of the sedative propofol is associated with a high risk for complications and even death in patients with prolonged seizures, according to a study by researchers at the Mayo Clinic in Rochester, Minn.

The study included 39 patients with refractory status epilepticus (RSE) -- prolonged seizures that don't respond to initial treatment. The condition occurs in patients with primary epilepsy and in those with other conditions such as trauma, tumors and infections that affect the brain.

Propofol is used to treat patients with RSE, but is more commonly used for sedation during surgery or other patient procedures. In those situations, propofol is used at a much lower dose and shorter duration than when it's used to treat RSE, according to background information in an American College of Chest Physicians news release on the Mayo study.

"Patients with RSE treated with propofol are at high risk for propofol-related side effects because of the high propofol infusion rates and prolonged treatment duration necessary in these patients. However, it is well described that propofol toxicity can occur even with brief exposure to the drug," study author Dr. Vivek Iyer, of the Mayo Clinic, said in the news release.

In the study, 39 patients (average age 54) were admitted to the intensive care unit with RSE. Thirty-two received propofol for a median of 63 hours and a median peak infusion rate of 67 micrograms per kilogram per minute. The other seven patients received other drugs, such as midazolam and pentobarbital.

In the propofol group, three patients had sudden unexplained cardiac arrest, resulting in two deaths. There were no deaths in the other group.

Thirty percent of patients in the propofol group experienced propofol infusion syndrome (PRIS), a serious complication defined by the unexplained presence of at least one or more of the following: the blood disorder known as metabolic acidosis; rhabdomyolysis (a muscle disorder); bradycardia (lowered heart rate); and/or cardiac arrest. PRIS occurred in one patients in the other group.

The findings indicate that doctors should be cautious in the use of propofol to treat patients with RSE, Iyer said.

"There are several other medications we can turn to in the case of uncontrolled seizures," he said. "Alternative agents should first be tried for patients with RSE, and propofol should only be used after exhausting all other options."

The study was to be presented Tuesday at CHEST 2008, the annual international scientific meeting of the American College of Chest Physicians, in Philadelphia.

More information

The Epilepsy Foundation has more about prolonged seizures.



-- Robert Preidt



SOURCE: American College of Chest Physicians, news release, Oct. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Newer Sedative Might Help Patients on Ventilators
2. A high-fat diet could promote the development of Alzheimers
3. Antiseizure Drug Could be Fatal
4. Anti-seizure drug could be fatal
5. Common epilepsy drug could prevent and treat Alzheimers disease
6. The Pink Ribbon That Could Save Your Life
7. With the Economy of the United States at a Turning Point, Health Care Could Be Our Next Serious Crisis ...
8. New Advances Could Battle Cancer Cell by Cell
9. Mayo Clinic estimates new, tiny, super-sensitive probe could cut colon polyp removal in half
10. New test could help catch serious infections in babies
11. New way to control protein activity could lead to cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sedative Could Be Deadly in People With Seizures
(Date:10/13/2017)... (PRWEB) , ... October 13, ... ... School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, ... professionals on guideline updates for the primary prevention of cardiovascular diseases during ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... FRISCO, Texas , Oct. 11, 2017 /PRNewswire/ ... healthcare services, has amplified its effort during National ... patients about hereditary cancer risks. ... Journal of Clinical Oncology calculated that more than ... to have inherited mutations in BRCA1 or BRCA2 and ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
Breaking Medicine Technology: