Navigation Links
Secrets of lung cancer drug resistance revealed at UCSF
Date:7/2/2012

People with lung cancer who are treated with the drug Tarceva face a daunting uncertainty: although their tumors may initially shrink, it's not a question of whether their cancer will returnit's a question of when. And for far too many, it happens far too soon.

Now, a team of researchers at the University of California, San Francisco's Helen Diller Family Comprehensive Cancer Center has discovered that a human protein called AXL drives resistance to Tarceva, which suggests that blocking the protein may prevent resistance to the cancer drug.

The discovery, described this week in Nature Genetics, may lead to better treatments involving precision medicines that would combine Tarceva with new drugs designed to block AXL.

"If we block AXL activation in the laboratory, we can overcome resistance to Tarceva," said Trever Bivona, MD, PhD, an assistant professor of hematology and oncology. "This paves the way for novel and more effective therapies."

In the experiments, Bivona and his colleagues used an inhibitor of AXL that is not an ideal clinical drug. But now Bivona and his team are working together with Kevan Shokat, PhD, a Howard Hughes Medical Institute Investigator and chair of the UCSF Department of Cellular and Molecular Pharmacology, to develop more potent AXL inhibitors for clinical testing.

Lung Cancer is Number One Cancer Killer

Lung cancer is the most common cause of cancer death worldwide. More people die from the disease each year than from breast, colon and prostate cancers combined. It claims more than 150,000 American lives annually and accounts for some 1.4 million deaths around the world. About 85 percent of Americans with all types of lung cancer die within five years of diagnosis.

Most cases result from exposure to cigarette smoke, but other causes include exposure to asbestos, chemicals, environmental factors and genetic susceptibility.

One thing that makes
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Dotcomsecrets is Offering New Opportunities to People Who Want to Become Expert in Localized Internet Marketing
2. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
3. 13 Free Weight Loss Secrets Program Kicks-Off
4. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. DotComSecrets Is Seeking Local DCS Consultants Through Free Webinars in Coming Days
7. Study Suggests Vaccine May Help Kids With Brain Cancer
8. New Stool Test Might Aid in Early Detection of Colon Cancer
9. Study reveals how cancer drug causes diabetic-like state
10. How a cancer drug leads to diabetes
11. You Survived Cancer: Now Pay Attention to Your Overall Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secrets of lung cancer drug resistance revealed at UCSF
(Date:4/23/2014)... The American Gastroenterological Association (AGA) Research Foundation is ... The AGA Research Scholar Awards program, launched in ... productive research careers in digestive diseases. This year, ... year allowing for three consecutive years of funding. ... who are paving the way for promising research ...
(Date:4/23/2014)... as wealthy as the United States, it may come as ... access to adequate food due to lack of money or ... research at the University of Illinois using data from the ... seniors who are dealing with hunger are also facing negative ... of Americans over age 60 faced the threat of hungerthat ...
(Date:4/23/2014)... about an increase in adolescents, marijuana use following the ... relief. According to a new study at Rhode Island ... states with and without medical marijuana laws, legalizing the ... The study is published online in advance of print ... , "Any time a state considers legalizing medical marijuana, ...
(Date:4/23/2014)... Methylphenidate, also known as Ritalin, may prevent the depletion ... Science , a journal of the Association for Psychological ... a diet or trying to focus attention on a ... suggests one potential explanation for this difficulty: Exerting self-control ... to exert self-control effectively on subsequent tasks. , "It ...
(Date:4/22/2014)... popular high school sport in the United States with ... researchers in the Center for Injury Research and Policy ... and describe the occurrence and distribution patterns of basketball-related ... athletic training setting among adolescents and teens. , The ... Training , examined data relating to adolescents 13-19 years ...
Breaking Medicine News(10 mins):Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:More Americans in their golden years are going hungry 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2Health News:ADHD drug may help preserve our self-control resources 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 3
... of the first, study finds , , WEDNESDAY, March 5 (HealthDay ... may be more likely to become pregnant again within two ... of Medicine study. , The study followed 269 predominately black ... care at five community sites. One or two years after ...
... Va. In many cases, when abusive parents with ... physical cruelty, authorities often remove the abused child from ... brothers and sisters of abused children can suffer lifelong ... in extreme cases, from being forced to participate in ...
... Relax The Back corporation,sold a record number of new ... locations were sold last year, and 12 new,stores opened. ... similarly,strong franchise sales results, with four stores already opened ... scheduled to open by June. The,company,s long-term goal is ...
... Members Confront Lazard Execs, Protest,Outside Atria Senior Living ... Workers, family members of,elderly residents at Atria Senior ... owner Lazard,s executives outside their,annual meeting of buyout ... hundreds of facilities across the country., Atria ...
... ability to control impulsive responses, study finds , , WEDNESDAY, ... a substance abuse disorder have deficits in frontal brain activation, ... MRI to study brain activity in 25 participants, ages 12 ... scientists found a link between increased risk for a substance ...
... 5 Secretary of,Health Dr. Calvin B. Johnson met ... in Ellwood City to discuss Governor Edward G. Rendell,s,plan ... thousands of,uninsured adults through his "Cover All Pennsylvanians" proposal., ... prevent disease,successfully manage chronic diseases, such as diabetes and ...
Cached Medicine News:Health News:Depression Raised Risk of Subsequent Pregnancies Among Black Teen Moms 2Health News:Authorities fail to recognize emotionally scarred brothers and sisters of child abuse victims 2Health News:Relax The Back Announces Record Growth in 2007; Executives Bullish on Specialty Retailer's Prospects for 2008 2Health News:New! Pull Back the Corporate Curtain at www.LazardUnveiled.org 2Health News:Deficit in Brain Function Puts Teens at Risk of Drug Abuse 2Health News:Health Secretary Visits Lawrence County to Call for Health Insurance for All Pennsylvanians 2
(Date:1/15/2014)... 2014 The Cadence Fitness & Health Center has ... Medical Fitness Association, a non-profit organization assisting medically integrated ... The Cadence Fitness & Health Center is the only ... in the Chicagoland area. "The certification means ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... - India Drug Forecast and Market Analysis ... PharmaPoint: Atopic Dermatitis - India ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... market research report is available in ... Global Markets and Technologies for Advanced ... Routes of Administration ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
... ConvaTec, a world-leading developer and marketer of ... today announced that Holy Family Medical Center will ... line of products designed to overcome the clinical ... Negative Pressure features the Engenex ® System ...
... 2011 iCyt Mission Technology, Inc. (iCyt), a wholly-owned ... introduction of its new line of 405nm-excited fluorochrome conjugated ... products are part of the first commercial release of ... exciting new class of fluorescent probes will make significant ...
Cached Medicine Technology:Holy Family Medical Center Selects ConvaTec Negative Pressure for Wound Care 2Holy Family Medical Center Selects ConvaTec Negative Pressure for Wound Care 3iCyt Unveils Exciting New Flow Cytometry Reagents Utilizing Innovative Fluorochrome Technology 2
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
Medicine Products: