Navigation Links
Secrets of cellular signaling shed light on new cancer stem cell therapies
Date:4/9/2008

Center, said Maillard's results are welcome news for cancer stem cell researchers, and for the 30-patient metastatic breast-cancer drug trial that launched last month at his center, at the Baylor College of Medicine in Houston, and at the Dana-Farber Cancer Institute in Boston.

"It's really important, because a lot of what we're thinking about now, therapeutically, is trying to find ways to attack these cancer stem cells, because we think that's really what drives the malignancies," said Wicha, who was not involved in the Notch study.

"Ivan's paper, combined with our own work, shows that there may be differences between normal stem cells and cancer stem cells, and perhaps those differences can be exploited therapeutically," Wicha said.

The cancer stem cell theory is controversial. Some researchers are not convinced that cancer stem cells exist.

The current two-stage drug trial uses a Notch inhibitor originally developed by Merck for Alzheimer's patients in the late 1990s, followed by chemotherapy. The intent is to use the Notch inhibitor to make cancer stem cells sensitive to the chemotherapy---a one-two punch to knock out tumors.

If the treatment is effective, the results could help sway some cancer-stem-cell skeptics.

The Notch pathway sends signals from a cell's surface membrane into its nucleus. Those signals activate genes that instruct the cell to make proteins that perform various tasks.

In the lab, Maillard and his colleagues were able to prevent Notch signals from activating mouse target genes using two independent techniques.

Many scientists have long assumed that blood-forming stem cells need Notch signals to function properly. But Maillard's team found that the signals are not required for the maintenance of blood-forming stem cells in adult mice.


'/>"/>

Contact: Jim Erickson
ericksn@umich.edu
734-647-1842
University of Michigan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Probe Sepsis Deadly Secrets
2. The Well Life Center in Mesa Unveils The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
3. UPCARE Technology to Share the Secrets of its Parents Success in Lab Outreach
4. Mathematicians help unlock secrets of the immune system
5. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
6. The Well Life Center in Mesa Continues The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
7. Secrets to Long-Lasting Marriages Revealed in Senior Survey
8. Oscar Makeover CHEAT Secrets of the Stars Revealed
9. HealthBarn(R) USA Founder Shares Secrets For Healthy Eating With Rachael Ray
10. Dr. Rovenia Brock Brings Secrets of Living Healthy to Susan G. Komen for the Cure(R)s Circle of Promise
11. Story ideas from molecular & cellular proteomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news ... the 42nd anniversary of the Supreme Court decision Roe v. Wade, ... years since the Roe vs. Wade decision and the fight to ... ever,” said City of West Hollywood Councilmember Abbe Land. “We need ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release of ... kids with cancer. The Chemo Duck App, available on iTunes for ... games to help children of all ages living with cancer adjust ... kids entertained, educated and at ease while waiting for clinic visits ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently ... thrilled to have it lead the wedding dress industry into ... prom dresses for the global market. , “The CEO of ... he focuses on continuing the goal of operational excellence and ...
(Date:1/22/2015)... January 23, 2015 Angelweddingdress is a famous ... invites its customers to follow it on Facebook, Twitter, and ... Valentine’s Day gift. Angelweddingdress draws a lottery every week. , ... to Feb. 28, 2015. Click Angelweddingdress homepage for ...
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2
... , WEDNESDAY, Aug. 25 (HealthDay News) -- Two of ... a connection, with new research suggesting that having insulin resistance ... brain plaques associated with Alzheimer,s disease. After adjusting for ... the highest levels of fasting insulin had nearly six times ...
... has filed an Investigational New Drug (IND) application with ... begin a Phase I safety clinical trial for chronic ... This multicenter Phase I safety trial will enroll a ... patients, with an American Spinal Injury Association (ASIA) Grade ...
... WEDNESDAY, Aug. 25 (HealthDay News) -- Cholesterol-lowering statins could ... among patients who are deemed to have an "intermediate ... The finding specifically applies to those men and women ... of a protein linked to inflammation (the so-called high ...
... Mayo Clinic discovered several years ago that laboratory samples of ... help them find new treatments for this lethal disease were ... evident that the situation in their lab was common throughout ... were supposed to originate from patients with this rare thyroid ...
... immunity to mumps is high in the United ... improved to prevent future outbreaks, according to a ... in the September 1, 2010 issue of The ... found in most parts of the worldcan cause ...
... 24, 2010) What does it feel like to return ... it has been difficult during astronaut training to realistically simulate ... Dr. Steven Moore leads a research group that has ... the sensory and mobility disturbances commonly experienced by astronauts after ...
Cached Medicine News:Health News:Link Between Diabetes, Alzheimer's Disease Strengthened 2Health News:Link Between Diabetes, Alzheimer's Disease Strengthened 3Health News:Link Between Diabetes, Alzheimer's Disease Strengthened 4Health News:Neuralstem files FDA application for first chronic spinal cord injury stem cell trial 2Health News:Neuralstem files FDA application for first chronic spinal cord injury stem cell trial 3Health News:Study Suggests Statins Could Help Some With Normal Cholesterol 2Health News:Study Suggests Statins Could Help Some With Normal Cholesterol 3Health News:Mayo researchers develop new laboratory cell lines to study treatment for ATC 2Health News:Mayo researchers develop new laboratory cell lines to study treatment for ATC 3Health News:Mumps vaccine coverage should be improved, study finds 2Health News:System uses electrical trickery on the brain to induce realistic spaceflight effects 2Health News:System uses electrical trickery on the brain to induce realistic spaceflight effects 3
(Date:1/23/2015)... FORT MYERS, Fla. , Jan. 23, 2015  Today ... approval of Novartis, Bexsero® for the prevention of ... to 25. Bexsero and Pfizer,s vaccine Trumenba®, which received ... in helping prevent this devastating disease. ...
(Date:1/23/2015)... Jan. 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released ... care leaders and a new study analyzing the impact of increased ... a nationwide coalition working to educate policy makers and the public ... Capitol was focused on how the Iowa ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third of ... of those with private insurance, filled a prescription for an ... report in this week,s Morbidity and Mortality Weekly Report (MMWR). ... providers to treat moderate to severe pain.  They are also ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... , SHANGHAI , May 11 /PRNewswire-Asia/ -- ... Hao Zhou as Chief Financial Officer,effective immediately. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ... Mr. Zhou joined the company in May 2009 ...
... Dynatronics Corporation (Nasdaq: DYNT ) plans to release financial results for its ... 17, 2010 .   , , , ... conference call for investors later that day at 1:30 p.m. ET to ... use passcode: 9921511. , , , ...
Cached Medicine Technology:WuXi PharmaTech Appoints Hao Zhou as Chief Financial Officer 2WuXi PharmaTech Appoints Hao Zhou as Chief Financial Officer 3
The double beveled oblique blade provides a true, straight incision. Penetrating through Bowman's and Descemet's membranes without inducing corneal distortion. No need to "Dimple Down"....
... The DioLite 532 laser is indicated ... pigmented skin lesions such as telangiectasia, ... wine stains, lentigines, dermatosis papulosis nigra ... offers unsurpassed reliability, a selection of ...
... Fingertips a comprehensive pocket-sized reference ... information on the evaluation and management of ... people. Updated annually. The complete content is ... versions for Pocket PC- and Palm-based PDAs ...
... is a fully integrated custom assay service that ... upon the assay of interest, the customer simply ... and we will provide a protocol and a ... the test in the laboratory. This will help ...
Medicine Products: