Navigation Links
Secrets of Telomerase Revealed
Date:9/1/2008

Researchers unlock active region of enzyme involved in cancer, aging

MONDAY, Sept. 1 (HealthDay News) -- Researchers have revealed the structure of the active region of telomerase, an enzyme involved in both cancer and aging.

Telomerase works by adding repeats of a short DNA sequence to the ends of chromosomes -- known as telomeres -- to prevent damage and loss of genetic information during cell division. Telomerase works in embryonic stem cells and other cells that multiply frequently, but is switched off almost entirely in normal adult cells to prevent the dangers of runaway proliferation.

In cancer cells, the ability to activate telomerase is often regained. Telomerase has been implicated in 90 percent of human tumors.

Because of this, telomerase is widely considered the number one target for the development of new cancer treatments. But until now, the enzyme's structure has been in large part a mystery.

"Telomerase is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most normal cells," study author Emmanuel Skordalakes, an assistant professor in The Wistar Institute's Gene Expression and Regulation Program, said in a news release from the institute.

In addition to telomerase's role in cancer, it also plays a part in aging. When telomerase is dormant, as it is in most normal adult cells, cells eventually become unstable and die. But when telomerase is active, cells continue living and dividing. This is why scientists believe that preserving telomerase under controlled conditions could possibly lead to new anti-aging therapies.

In their study, which was published in the Aug. 31 issue of Nature, Skordalakes and his colleagues found that they could use a gene from the red flour beetle to produce large amounts of telomerase in a stable form for study.

"That was really the breakthrough," said Skordalakes. "Once we found that the gene from this organism expressed the protein in the quantities we needed, we were able to move quickly."

Using X-ray crystallography, the researchers were then able to determine the three-dimensional structure of telomerase's active region.

"It's extremely exciting," said Skordalakes. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication."

Skordalakes plans to further investigate the active region of telomerase and search for new potential cancer therapies.

More information

The American Cancer Society has more about cancer.



--Krisha McCoy



SOURCE: The Wistar Institute, news release, Aug. 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Probe Sepsis Deadly Secrets
2. The Well Life Center in Mesa Unveils The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
3. UPCARE Technology to Share the Secrets of its Parents Success in Lab Outreach
4. Mathematicians help unlock secrets of the immune system
5. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
6. The Well Life Center in Mesa Continues The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
7. Secrets to Long-Lasting Marriages Revealed in Senior Survey
8. Oscar Makeover CHEAT Secrets of the Stars Revealed
9. HealthBarn(R) USA Founder Shares Secrets For Healthy Eating With Rachael Ray
10. Dr. Rovenia Brock Brings Secrets of Living Healthy to Susan G. Komen for the Cure(R)s Circle of Promise
11. Secrets of cellular signaling shed light on new cancer stem cell therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secrets of Telomerase Revealed
(Date:6/23/2017)... ... , ... PureLife Dental is pleased to announce that California Dental Association (CDA) ... of the amalgam separator endorsement, all CDA members may purchase an ECO II amalgam ... value. This partnership between PureLife and CDA is especially timely as it coincides with ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. Hansen, Inc ... to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check ... founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of how to ...
(Date:6/23/2017)... ... June 23, 2017 , ... The ... related services to families and business owners in and around Lackawanna County, is ... senior citizens in the area. , Meals on Wheels of NEPA provides hand-delivered ...
(Date:6/23/2017)... Gilmer, TX (PRWEB) , ... June 23, 2017 , ... ... consultations to residential and business clients throughout eastern Texas, is announcing the launch of ... , Recent breast cancer statistics in the United States reveal that an estimated ...
(Date:6/23/2017)... The Woodlands, TX (PRWEB) , ... June 23, ... ... provides families and business owners in the Houston area with access to asset ... Foundation for a regional charity event aimed at improving the lives of children ...
Breaking Medicine News(10 mins):
(Date:6/10/2017)... 2017  Shane K. Burchfield, DPM, is recognized by Continental Who,s ... Podiatrist in Alabama . Dr. ... Care. He brings over 20 years of experience, as well as ... to his role. ... pleased to welcome you to his practice," the company,s ...
(Date:6/9/2017)... , June 9, 2017 More than ... further effort to help spread lessons learned from clinical ... International Diabetes Federation (IDF) and Eli Lilly and Company ... the second phase of the Bringing Research in Diabetes ... their commitment to helping people with diabetes effectively manage ...
(Date:6/8/2017)... , June 8, 2017   Responding to Heath ... and the death of singer Chris Cornell in ... Rights International offers a free online psychiatric ... consumers and families about psychotropic drug risks. ... who died from an accidental overdose, has called for tighter ...
Breaking Medicine Technology: