Navigation Links
Secrets of Telomerase Revealed
Date:9/1/2008

Researchers unlock active region of enzyme involved in cancer, aging

MONDAY, Sept. 1 (HealthDay News) -- Researchers have revealed the structure of the active region of telomerase, an enzyme involved in both cancer and aging.

Telomerase works by adding repeats of a short DNA sequence to the ends of chromosomes -- known as telomeres -- to prevent damage and loss of genetic information during cell division. Telomerase works in embryonic stem cells and other cells that multiply frequently, but is switched off almost entirely in normal adult cells to prevent the dangers of runaway proliferation.

In cancer cells, the ability to activate telomerase is often regained. Telomerase has been implicated in 90 percent of human tumors.

Because of this, telomerase is widely considered the number one target for the development of new cancer treatments. But until now, the enzyme's structure has been in large part a mystery.

"Telomerase is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most normal cells," study author Emmanuel Skordalakes, an assistant professor in The Wistar Institute's Gene Expression and Regulation Program, said in a news release from the institute.

In addition to telomerase's role in cancer, it also plays a part in aging. When telomerase is dormant, as it is in most normal adult cells, cells eventually become unstable and die. But when telomerase is active, cells continue living and dividing. This is why scientists believe that preserving telomerase under controlled conditions could possibly lead to new anti-aging therapies.

In their study, which was published in the Aug. 31 issue of Nature, Skordalakes and his colleagues found that they could use a gene from the red flour beetle to produce large amounts of telomerase in a stable form for study.

"That was really the breakthrough," said Skordalakes. "Once we found that the gene from this organism expressed the protein in the quantities we needed, we were able to move quickly."

Using X-ray crystallography, the researchers were then able to determine the three-dimensional structure of telomerase's active region.

"It's extremely exciting," said Skordalakes. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication."

Skordalakes plans to further investigate the active region of telomerase and search for new potential cancer therapies.

More information

The American Cancer Society has more about cancer.



--Krisha McCoy



SOURCE: The Wistar Institute, news release, Aug. 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Probe Sepsis Deadly Secrets
2. The Well Life Center in Mesa Unveils The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
3. UPCARE Technology to Share the Secrets of its Parents Success in Lab Outreach
4. Mathematicians help unlock secrets of the immune system
5. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
6. The Well Life Center in Mesa Continues The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
7. Secrets to Long-Lasting Marriages Revealed in Senior Survey
8. Oscar Makeover CHEAT Secrets of the Stars Revealed
9. HealthBarn(R) USA Founder Shares Secrets For Healthy Eating With Rachael Ray
10. Dr. Rovenia Brock Brings Secrets of Living Healthy to Susan G. Komen for the Cure(R)s Circle of Promise
11. Secrets of cellular signaling shed light on new cancer stem cell therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secrets of Telomerase Revealed
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile app ... struggle to reverse the tide of prescription drug addiction. The ... their medicine intake and stepping down their dosage in a ... launch in December 2017; the first 100,000 people to sign ... at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
Breaking Medicine Technology: