Navigation Links
Secrets of Telomerase Revealed
Date:9/1/2008

Researchers unlock active region of enzyme involved in cancer, aging

MONDAY, Sept. 1 (HealthDay News) -- Researchers have revealed the structure of the active region of telomerase, an enzyme involved in both cancer and aging.

Telomerase works by adding repeats of a short DNA sequence to the ends of chromosomes -- known as telomeres -- to prevent damage and loss of genetic information during cell division. Telomerase works in embryonic stem cells and other cells that multiply frequently, but is switched off almost entirely in normal adult cells to prevent the dangers of runaway proliferation.

In cancer cells, the ability to activate telomerase is often regained. Telomerase has been implicated in 90 percent of human tumors.

Because of this, telomerase is widely considered the number one target for the development of new cancer treatments. But until now, the enzyme's structure has been in large part a mystery.

"Telomerase is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most normal cells," study author Emmanuel Skordalakes, an assistant professor in The Wistar Institute's Gene Expression and Regulation Program, said in a news release from the institute.

In addition to telomerase's role in cancer, it also plays a part in aging. When telomerase is dormant, as it is in most normal adult cells, cells eventually become unstable and die. But when telomerase is active, cells continue living and dividing. This is why scientists believe that preserving telomerase under controlled conditions could possibly lead to new anti-aging therapies.

In their study, which was published in the Aug. 31 issue of Nature, Skordalakes and his colleagues found that they could use a gene from the red flour beetle to produce large amounts of telomerase in a stable form for study.

"That was really the breakthrough," said Skordalakes. "Once we found that the gene from this organism expressed the protein in the quantities we needed, we were able to move quickly."

Using X-ray crystallography, the researchers were then able to determine the three-dimensional structure of telomerase's active region.

"It's extremely exciting," said Skordalakes. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication."

Skordalakes plans to further investigate the active region of telomerase and search for new potential cancer therapies.

More information

The American Cancer Society has more about cancer.



--Krisha McCoy



SOURCE: The Wistar Institute, news release, Aug. 31, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists Probe Sepsis Deadly Secrets
2. The Well Life Center in Mesa Unveils The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
3. UPCARE Technology to Share the Secrets of its Parents Success in Lab Outreach
4. Mathematicians help unlock secrets of the immune system
5. New Survey Uncovers Dirty Little Secrets About Americas Oral Care Habits
6. The Well Life Center in Mesa Continues The 10 Healing Secrets to Health & Longevity Lecture. Proceeds Benefit The Arizona Special Olympics
7. Secrets to Long-Lasting Marriages Revealed in Senior Survey
8. Oscar Makeover CHEAT Secrets of the Stars Revealed
9. HealthBarn(R) USA Founder Shares Secrets For Healthy Eating With Rachael Ray
10. Dr. Rovenia Brock Brings Secrets of Living Healthy to Susan G. Komen for the Cure(R)s Circle of Promise
11. Secrets of cellular signaling shed light on new cancer stem cell therapies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secrets of Telomerase Revealed
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. Stock-Callers.com assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: