Navigation Links
Secret of Anesthesia Revealed, Study Says
Date:10/25/2012

THURSDAY, Oct. 25 (HealthDay News) -- General anesthesia drugs really do put patients to sleep, suggests research conducted in mice.

The study found that the drugs don't just turn wakefulness off, they also switch on important sleep circuits in the brain, according to the findings, which were published online Oct. 25 in the journal Current Biology.

"Despite more than 160 years of continuous use in humans, we still do not understand how anesthetic drugs work to produce the state of general anesthesia," Dr. Max Kelz, an anesthesiologist at the University of Pennsylvania, said in a journal news release.

"We show that a commonly used inhaled anesthetic drug directly causes sleep-promoting neurons to fire," Kelz said. "We believe that this result is not simply a coincidence. Rather, our view is that many general anesthetics work to cause unconsciousness in part by recruiting the brain's natural sleep circuitry, which initiates our nightly journey into unconsciousness."

Kelz and his colleagues focused on an area of the brain deep within the hypothalamus, which is known to become more active as a person goes to sleep. They found that the anesthesia drug isoflurane boosts activity in this area of the brain in mice. They also found that mice with non-functioning neurons in this area were more resistant to the drug.

"The development of anesthetic drugs has been hailed as one of humankind's greatest discoveries in the last thousand years," Kelz said. "Anesthetics are annually given to over 230 million patients worldwide. Yet as a society, and even within the anesthesia community, we seem to have lost our curiosity for how and why they work."

He noted that there are important differences between natural sleep and the unconscious state caused by general anesthesia. Even the soundest sleeper can be awakened, but anesthetized patients remain unconscious throughout the trauma inflicted on their bodies during surgery.

Although the research with mice was revealing, experts note that animal experiments don't always produce the same results when applied to human subjects.

More information

The MedlinePlus Medical Encyclopedia has more about general anesthesia.

-- Robert Preidt

SOURCE: Current Biology, news release, Oct. 25, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Unmasking the deadly secrets of pancreatic cancer
2. UMass Amherst researchers unravel secrets of parasites replication
3. Could the Naked Mole Rat Hold Secrets to Longevity?
4. Secrets of lung cancer drug resistance revealed at UCSF
5. DotComSecrets Is Seeking Local DCS Consultants Through Free Webinars in Coming Days
6. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
7. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
8. 13 Free Weight Loss Secrets Program Kicks-Off
9. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
10. Dotcomsecrets is Offering New Opportunities to People Who Want to Become Expert in Localized Internet Marketing
11. Survival After General Anesthesia Vastly Improved: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Secret of Anesthesia Revealed, Study Says
(Date:1/23/2017)... ... January 23, 2017 , ... Old School Labs™, makers ... Mr. Olympia Classic Physique bodybuilder Breon Ansley to its growing team of brand ambassadors. ... bodybuilder in 2012 and in less than a year was able to turn professional, ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources to assist in teaching communities and individuals ... have been developed for use by nutrition educators and influencers within the ...
(Date:1/22/2017)... ... 22, 2017 , ... Zifam Pinnacle, an Australian company dedicated to providing a ... retail buyers at the January ECRM Trade Show in Hilton Head, SC. , Zifam ... standards in all of its creations to help create a more traditional and natural ...
(Date:1/21/2017)... ... January 21, 2017 , ... "ProDOF is the perfect set of tools for video editors that ... a scene," said Christina Austin - CEO of Pixel Film Studios. , Video editors ... the illusion of a DSLR racking focus from one area into the next. ProDOF ...
(Date:1/21/2017)... CA (PRWEB) , ... January 21, 2017 , ... ... opening of its new medical office in Petaluma, located at 167 Lynch Creek ... room, access to SRO sports medicine and rehabilitation services and on-site ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Germany Cataract Surgery Devices Market ... "Germany Cataract Surgery Devices Market Outlook to 2022", provides ... market. The report provides value, in millions of US ... market segements - Phacoemulsification Equipment and Ophthalmic Viscoelastic Devices ... distribution shares data for each of these market segements, ...
(Date:1/19/2017)... Md. , Jan. 19, 2017 The U.S. ... treatment of Chronic Idiopathic Constipation (CIC) in adult patients. ... from chronic gastrointestinal disorders," said Julie Beitz , M.D., ... FDA,s Center for Drug Evaluation and Research. "With the availability ... most appropriate treatment for their condition." ...
(Date:1/19/2017)... ATLANTIC CITY, N.J. , Jan. 19, 2017 /PRNewswire/ ... paying over $100 for their medication when a pharmacy ... the same exact prescription.  To alleviate this problem ... doctors and patients to see exactly how much their ... Comparison Shopping Made Easy ...
Breaking Medicine Technology: