Navigation Links
Secret of Anesthesia Revealed, Study Says

THURSDAY, Oct. 25 (HealthDay News) -- General anesthesia drugs really do put patients to sleep, suggests research conducted in mice.

The study found that the drugs don't just turn wakefulness off, they also switch on important sleep circuits in the brain, according to the findings, which were published online Oct. 25 in the journal Current Biology.

"Despite more than 160 years of continuous use in humans, we still do not understand how anesthetic drugs work to produce the state of general anesthesia," Dr. Max Kelz, an anesthesiologist at the University of Pennsylvania, said in a journal news release.

"We show that a commonly used inhaled anesthetic drug directly causes sleep-promoting neurons to fire," Kelz said. "We believe that this result is not simply a coincidence. Rather, our view is that many general anesthetics work to cause unconsciousness in part by recruiting the brain's natural sleep circuitry, which initiates our nightly journey into unconsciousness."

Kelz and his colleagues focused on an area of the brain deep within the hypothalamus, which is known to become more active as a person goes to sleep. They found that the anesthesia drug isoflurane boosts activity in this area of the brain in mice. They also found that mice with non-functioning neurons in this area were more resistant to the drug.

"The development of anesthetic drugs has been hailed as one of humankind's greatest discoveries in the last thousand years," Kelz said. "Anesthetics are annually given to over 230 million patients worldwide. Yet as a society, and even within the anesthesia community, we seem to have lost our curiosity for how and why they work."

He noted that there are important differences between natural sleep and the unconscious state caused by general anesthesia. Even the soundest sleeper can be awakened, but anesthetized patients remain unconscious throughout the trauma inflicted on their bodies during surgery.

Although the research with mice was revealing, experts note that animal experiments don't always produce the same results when applied to human subjects.

More information

The MedlinePlus Medical Encyclopedia has more about general anesthesia.

-- Robert Preidt

SOURCE: Current Biology, news release, Oct. 25, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Unmasking the deadly secrets of pancreatic cancer
2. UMass Amherst researchers unravel secrets of parasites replication
3. Could the Naked Mole Rat Hold Secrets to Longevity?
4. Secrets of lung cancer drug resistance revealed at UCSF
5. DotComSecrets Is Seeking Local DCS Consultants Through Free Webinars in Coming Days
6. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
7. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
8. 13 Free Weight Loss Secrets Program Kicks-Off
9. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
10. Dotcomsecrets is Offering New Opportunities to People Who Want to Become Expert in Localized Internet Marketing
11. Survival After General Anesthesia Vastly Improved: Study
Post Your Comments:
Related Image:
Secret of Anesthesia Revealed, Study Says
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: ... a number of ,world firsts,: , TwinLink™ ...
Breaking Medicine Technology: