Navigation Links
Secondhand smoke results in graft rejection
Date:2/23/2012

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

Led by Zhenhua Dai, MD, PhD, of the University of Texas Health Science Center, researchers used mouse transplant models to investigate the impact of second hand smoke (SHS) on transplant survival and its mechanism of action.

Seven to eight mice per group were exposed to SHS and treated with or without immunoregulatory agents. They were exposed to SHS 4 weeks before they were transplanted with islets under the kidney capsule. SHS was terminated once islet allografts were rejected. Recipient mice were untreated or exposed to SHS. The analysis of graft survival was performed using log-rank tests.

Results showed that SHS indeed harms long-term allograft survival. SHS suppressed expression of an enzyme in the grafts produced by innate immune cells. SHS hindered long-term islet allograft survival induced by CD154 costimulatory blockade via suppressing IDO expression and activity, while overexpression of IDO by islets restored their long-term survival.

These findings for the first time revealed an immunological mechanism underlying allograft rejection precipitated by the exposure to cigarette smoke.

"Many people are not aware of the gradual failure of transplanted organs or grafts that is caused by cigarette smoking, although they do know that smoking can cause cancer as well as respiratory diseases," Dai notes. "Our findings will definitely promote the public awareness of the smoking problem with transplanted patients, which in turn could save their lives by either quitting smoking or avoiding exposure to second hand smoke after transplantation."


'/>"/>

Contact: Amy Molnar
healthnews@wiley.com
201-748-8844
Wiley-Blackwell
Source:Eurekalert

Page: 1

Related medicine news :

1. Exposure to secondhand smoke among children in England has declined since 1996
2. Research finds hazards from secondhand smoke in bars and restaurants
3. Secondhand Smoke Starts Damaging Arteries in Childhood
4. Secondhand Smoke Boosts Sinusitis Risk
5. Smoke-free air laws effective at protecting children from secondhand smoke
6. Secondhand Smoke May Put Kids at Risk for Diseases
7. Secondhand television exposure linked to eating disorders
8. Secondhand Smoke Tied to High Blood Pressure in Kids
9. Moderate levels of secondhand smoke deliver nicotine to the brain
10. Secondhand Smoke May Trigger Nicotine Craving
11. ADHD, Learning Issues May Be Linked to Secondhand Smoke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... , ... Despite last week’s media reports hinting at a June rate hike ... March 2017 for an interest rate increase, according to Rajeev Dhawan of the Economic ... Federal Open Market Committee (FOMC) dot charts are of interest to the press for ...
(Date:5/26/2016)... Hampshire (PRWEB) , ... May 26, 2016 , ... ... care products, has been honored with a 2016 When Work Works Award for its ... award, part of the national When Work Works project administered by the Families and ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
(Date:5/26/2016)... ... 2016 , ... Connor Sports, through its Connor Cares initiative, will ... Tamika Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career ... all forms and levels of the game, Connor Sports has committed to a significantly ...
(Date:5/26/2016)... ... , ... The Woodlands at John Knox Village , Florida’s first Life ... living and healing, celebrated its grand opening, today. The Woodlands at John Knox Village ... Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village as ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Granger Diagnostics today ... test for wounds and infections. This test ensures ... and select viruses. The test requires only a ... David G. Bostwick , MD, ... to facilitate wound healing: "We are excited to ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
(Date:5/24/2016)... -- Cirujanos holandeses han puesto en marcha ... a compartir sus mejores prácticas por el mundo y ... de Europa, África, Asia y ... que combina la transmisión en vivo con mensajería instantánea ... Educación   "Imagine un médico de Medicines sans ...
Breaking Medicine Technology: