Navigation Links
Second opinion changes diagnosis from incurable to curable cancer
Date:5/12/2014

AURORA, Colo. (May 5, 2014) - The Journal of Clinical Oncology reports the case of a woman diagnosed with advanced, incurable lung cancer, whose disease was in fact early stage, curable lung cancer with additional lung lesions due to a rare antibiotic side effect. When her primary lung tumor was surgically removed, and the antibiotic stopped, the 62-year-old woman recovered and may now be cured.

"In a good example of collaboration with our local oncology community, my colleague wanted a second opinion to ensure his patient got the best possible treatment plan established from the get-go, said Ross Camidge, MD, PhD, director of the thoracic oncology clinical program at the University of Colorado Cancer Center and the senior author of the study. "Initially, they were probably looking for some kind of molecular profiling and possibly a novel drug or combination of drugs in a clinical trial. Instead, through some great teamwork, we were able to reveal something unexpected and radically change her prognosis."

The patient, a former smoker, visited her doctor with a cough, fatigue and weight loss. Her scans revealed a dominant mass in her right lung with multiple smaller nodules and infiltrates throughout both lungs. The biggest mass was biopsied and showed non-small cell lung cancer. Because the disease appeared throughout both lungs, the patient appeared to have advanced stage or metastatic lung cancer, a condition which nationally, is associated with a 5-year survival rate of less than 3 percent.

"But then Eiko Browning, MD, our outstanding senior trainee in oncology, began to notice a series of clues that something else was happening," said Camidge.

First, there were changes in the patient's blood tests showing some damage to the liver, but there were no signs of cancer in the liver. Second, the CU team noticed she also had a long history of urinary tract infections treated with the antibiotic, nitrofurantoin.

Nicole Restauri, MD, the CU radiologist reviewing the scans, then pointed out the little known fact that about one in 100,000 women who take nitrofurantoin experience unusual side effects, including liver and lung damage. Consequently, Camidge and colleagues hypothesized that toxicity due to the antibiotic, and not spread of the lung cancer, could have created the appearance of widespread lung abnormalities. To prove this, they stopped the antibiotic and simply repeated the scans and blood tests a few weeks later. When the liver tests returned to normal and everything except the known lung cancer had disappeared from her scans, the team was able to change her diagnosis from incurable, metastatic lung cancer to early stage, curable lung cancer.

"The prompt, correct diagnosis dramatically changed this patient's care," Camidge said. "Instead of suggesting that this patient undergo standard chemotherapy or treatment in clinical trials, we simply performed surgery. She is now in long-term follow-up care with no evidence of cancer recurrence to date."

Camidge goes on to say, "This is a great example of a community oncologist pushing for the best treatment plan for their patient by actively seeking out a second opinion before commencing treatment. While not always this dramatic, this certainly illustrates the full extent of what a second opinion from an expert multi-disciplinary team can accomplish. When you are dealing with something as serious as cancer, getting another set of eyes to look things over early on can sometimes pay huge dividends."


'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Round 2: Reactions serves up a second helping of chemistry life hacks (video)
2. Second largest research award at Notre Dame fights malaria and dengue fever
3. Immune cells need a second opinion
4. Secondhand smoke exposure increases odds of hospital asthma readmission for children
5. Sound Relief Hearing Center Announces the Winner of Their Second Annual "Gift of Better Hearing" Contest
6. MDA Awards Second 'Bridge-to-Industry' Grant
7. Study Documents Secondhand Exposure to Nicotine from Electronic Cigarette Vapor
8. First-annual Connecticut Cannabis Exposition Arrives in The Nutmeg States' Second Largest City, New Haven
9. The Russian Banya, a Second Mother
10. US Freedom Capital Announces Second Regional Center
11. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... "TransFlare 4K ... use inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... RED Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and light leak transitions ...
(Date:1/20/2017)... ... , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on to ... published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of 5, ... years of age, he joined the Navy and got married right out of boot camp. ...
(Date:1/20/2017)... ... ... enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is the ... devoted woman of faith. , “Becoming a parent changes you. In my case, the ... years, but actually doing it might have been a while in coming if it hadn’t ...
(Date:1/19/2017)... ... ... Today, the Centers for Medicare & Medicaid Services (CMS) announced over 359,000 clinicians ... Clinicians who participate in APMs are paid for the quality of care they give ... build a system that delivers better care and one in which clinicians work together ...
(Date:1/19/2017)... ... 2017 , ... With the cold weather here, many people will have to clear snow with ... large amounts of snow, but they can be dangerous when used incorrectly. That’s why ... for the proper use of snow blowers:, , When removing wet ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... India , January 20, 2017 According ... Type (Descriptive, Prescriptive), Application (Marketing, R&D, Compliance, SCM), Component (Software, Service), ... - Forecasts to 2021" published by MarketsandMarkets, the market is expected ... in 2016, at a CAGR of 13.3% during the forecast period. ... ...
(Date:1/21/2017)... , Jan. 20, 2017  Today, ... Symposia Conference, "PI3K Pathways in Immunology, Growth ... (NASDAQ: INFI ) presented ... development candidate that selectively inhibits phosphoinositide-3-kinase-gamma (PI3K-gamma). ... to help overcome resistance to checkpoint inhibition ...
(Date:1/21/2017)...  Faruqi & Faruqi, LLP, a leading national securities law ... (NASDAQ: KMPH ) of the federal securities class ... directors and underwriters of the Company,s April 16, 2015 Initial ... plaintiff. The lawsuit has been filed in the ... Johnson County on behalf of all those who ...
Breaking Medicine Technology: