Navigation Links
Second opinion changes diagnosis from incurable to curable cancer
Date:5/12/2014

AURORA, Colo. (May 5, 2014) - The Journal of Clinical Oncology reports the case of a woman diagnosed with advanced, incurable lung cancer, whose disease was in fact early stage, curable lung cancer with additional lung lesions due to a rare antibiotic side effect. When her primary lung tumor was surgically removed, and the antibiotic stopped, the 62-year-old woman recovered and may now be cured.

"In a good example of collaboration with our local oncology community, my colleague wanted a second opinion to ensure his patient got the best possible treatment plan established from the get-go, said Ross Camidge, MD, PhD, director of the thoracic oncology clinical program at the University of Colorado Cancer Center and the senior author of the study. "Initially, they were probably looking for some kind of molecular profiling and possibly a novel drug or combination of drugs in a clinical trial. Instead, through some great teamwork, we were able to reveal something unexpected and radically change her prognosis."

The patient, a former smoker, visited her doctor with a cough, fatigue and weight loss. Her scans revealed a dominant mass in her right lung with multiple smaller nodules and infiltrates throughout both lungs. The biggest mass was biopsied and showed non-small cell lung cancer. Because the disease appeared throughout both lungs, the patient appeared to have advanced stage or metastatic lung cancer, a condition which nationally, is associated with a 5-year survival rate of less than 3 percent.

"But then Eiko Browning, MD, our outstanding senior trainee in oncology, began to notice a series of clues that something else was happening," said Camidge.

First, there were changes in the patient's blood tests showing some damage to the liver, but there were no signs of cancer in the liver. Second, the CU team noticed she also had a long history of urinary tract infections treated with the antibiotic, nitrofurantoin.

Nicole Restauri, MD, the CU radiologist reviewing the scans, then pointed out the little known fact that about one in 100,000 women who take nitrofurantoin experience unusual side effects, including liver and lung damage. Consequently, Camidge and colleagues hypothesized that toxicity due to the antibiotic, and not spread of the lung cancer, could have created the appearance of widespread lung abnormalities. To prove this, they stopped the antibiotic and simply repeated the scans and blood tests a few weeks later. When the liver tests returned to normal and everything except the known lung cancer had disappeared from her scans, the team was able to change her diagnosis from incurable, metastatic lung cancer to early stage, curable lung cancer.

"The prompt, correct diagnosis dramatically changed this patient's care," Camidge said. "Instead of suggesting that this patient undergo standard chemotherapy or treatment in clinical trials, we simply performed surgery. She is now in long-term follow-up care with no evidence of cancer recurrence to date."

Camidge goes on to say, "This is a great example of a community oncologist pushing for the best treatment plan for their patient by actively seeking out a second opinion before commencing treatment. While not always this dramatic, this certainly illustrates the full extent of what a second opinion from an expert multi-disciplinary team can accomplish. When you are dealing with something as serious as cancer, getting another set of eyes to look things over early on can sometimes pay huge dividends."


'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Round 2: Reactions serves up a second helping of chemistry life hacks (video)
2. Second largest research award at Notre Dame fights malaria and dengue fever
3. Immune cells need a second opinion
4. Secondhand smoke exposure increases odds of hospital asthma readmission for children
5. Sound Relief Hearing Center Announces the Winner of Their Second Annual "Gift of Better Hearing" Contest
6. MDA Awards Second 'Bridge-to-Industry' Grant
7. Study Documents Secondhand Exposure to Nicotine from Electronic Cigarette Vapor
8. First-annual Connecticut Cannabis Exposition Arrives in The Nutmeg States' Second Largest City, New Haven
9. The Russian Banya, a Second Mother
10. US Freedom Capital Announces Second Regional Center
11. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: