Navigation Links
Second-line CML drugs evoke faster, better front-line remissions
Date:6/5/2010

dose nilotinib, the numbers were 78 percent, 43 percent and also less than 1 percent.

In the imatinib arm, 65 percent achieved complete cytogenetic response, 22 percent reached major molecular response, and 4 percent had their disease progress.

Patients on nilotinib achieved major molecular response earlier than those on imatinib, with median times to MMR of 5.7 and 5.8 months, compared with 8.3 months for imatinib.

Nilotinib and imatinib had favorable safety profiles, with serious side effects uncommon for either drug. Hematologic side effects decreased levels of red blood cells, white blood cells or platelets -- were slightly more common among those on imatinib. Nausea, diarrhea, vomiting, muscle spasms and edema were higher on imatinib, but rash, headache, hair loss and itching were higher on nilotinib.

Novartis, the company that makes imatinib, also developed nilotinib, and Bristol-Myers Squibb developed dasatinib, both of which are more potent inhibitors of the BCR-ABL protein. The two drugs are approved as second-line therapy after imatinib fails or as first therapy for those who cannot take imatinib. Both companies are expected to seek U.S. Food and Drug Administration approval for the two drugs as initial therapy for CML.

"Findings from both of these studies confirm the single-arm trials done at MD Anderson, which had shown superiority of second-generation drugs in a front-line setting," Kantarjian said. The two ongoing single-arm clinical trials, led by Jorge Cortes, M.D., professor in MD Anderson's Department of Leukemia, compare the performance of the drugs in new patients to historical results from earlier trials of imatinib.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Second-line CML drugs evoke faster response than front-line therapy
2. Patient age not a factor in use of second-line therapy for lung cancer
3. Second-line CML drug evokes faster response, fewer side effects, pivotal study finds
4. New Drugs, New Combinations Fight Breast Cancer
5. NICE guidelines ration affordable osteoporosis drugs
6. Bone Drugs May Beat Back Breast Cancer
7. Rehabilitation for Opiate Addiction Without Maintenance Drugs
8. Review and approval of oncology and hematology drugs at FDA from 2005 to 2007
9. Fake Drugs Bought on the Web Pose Big Health Risks
10. Scientists show how molecular switch helps pancreatic cancer beat drugs
11. Common antidepressant drugs linked to lactation difficulties in moms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 Utilizing the Keller Funnel, ... William Koenig, has topped a record number of complication-free ... performed over 400 successful procedures without the occurrence of ... well known across the country for his expertise with ... has long been the foundation for numerous studies and ...
(Date:7/11/2014)... Ticket Down is a reliable source ... When it comes to the summer concert schedule, it just ... native is one of the biggest names in country music and ... currently out on his “That’s My Kind of Night” tour featuring ... will be making through the rest of the summer and into ...
(Date:7/11/2014)... are widely applied in turf and ornamentals. They enhance ... turf and ornamentals in absorption of water, nutrient uptake, ... appear healthy and strong as a result of using ... few years. The most dominating region in biostimulants markets ... share in 2013, and is estimated to grow at ...
(Date:7/11/2014)... PULLMAN, Wash.The largest study of its kind has ... suite of advantages over their conventional counterparts, including ... , The study looked at an unprecedented 343 ... of organic and conventional plant-based foods, including fruits, ... meta-analysis techniques to quantify differences between organic and ...
(Date:7/11/2014)... Ticket Down is a reliable source for cheap Luke ... Over the years Luke Bryan has been honored by almost every ... well at award shows, but each summer, he hits the road ... the genre and this summer is more of the same. When ... popularity and success that is currently entitled to Luke Bryan. The ...
Breaking Medicine News(10 mins):Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:Biostimulants Market in Turf and Ornamentals is Expected to Reach $ 3.8 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:Major study documents nutritional and food safety benefits of organic farming 2Health News:Major study documents nutritional and food safety benefits of organic farming 3Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 2Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 3
... complaints show it may not be for everyone , , FRIDAY, ... vision-correcting LASIK surgery as "life changing." NASA now allows astronauts ... has been performed on 112,500 military personnel, including pilots. ... this elective surgery being lost in this laudatory celebration? ...
... of Deep Brain Stimulation, or ,Brain,Pacemakers, on the ... WASHINGTON, April 25 The U.S. Department ... are teaming up to,raise awareness about deep brain ... disorders and disabilities., HHS, Office on Disability ...
... Leinbach, a,9-year-old student in Mrs. Sheri Fetterhoff,s ... County, will receive a $1,000,educational bond for ... 2008 National Children,s Dental Health Month (NCDHM),statewide ... reproduced as bookmarks, which will be,distributed to ...
... The United States,Agency for International Development (USAID) is ... solution that reduces the risk of,diarrhea. Sur,Eau is ... chlorine solution can be added to water immediately ... principally young children and,people living with HIV and ...
... April 25 The Michigan,Chamber of Commerce today announced ... find its way to the November 2008 ballot and,constitutionally ... care system. The Michigan Chamber cited serious concerns with ... and the fact,that Michigan job providers and taxpayers would ...
... 25 SynergEyes, Inc., of Carlsbad, CA,recently launched ... need further vision correction after undergoing refractive vision,surgery. ... who,have experienced some type of corneal trauma or ... millions of people undergo LASIK or other types ...
Cached Medicine News:Health News:FDA Panel Urges Stronger Warnings for LASIK Surgery 2Health News:FDA Panel Urges Stronger Warnings for LASIK Surgery 3Health News:FDA Panel Urges Stronger Warnings for LASIK Surgery 4Health News:HHS, Cleveland Clinic Collaborate to Advance Treatment for Neurological Disorders 2Health News:HHS, Cleveland Clinic Collaborate to Advance Treatment for Neurological Disorders 3Health News:Pennsylvania Dental Association Announces Winners of Annual Statewide Third-grade Student Poster Contest 2Health News:Disinfecting Water Saves Lives in Rwanda 2Health News:Michigan Chamber of Commerce Opposes 'Blank Check' Healthcare Ballot Proposal 2Health News:SynergEyes Hybrid Contact Lenses Provide a Vision Solution for Post-LASIK Patients 2
(Date:7/10/2014)... July 10, 2014 Decision Resources Group finds ... the U.S. Food and Drug Administration,s (FDA) approval of ... Velphoro, which was approved by the FDA in November ... disease (CKD) patients on dialysis. Other key ... (US) Q2 2014 : ...
(Date:1/15/2014)... Jan. 15, 2014 Most osteoporosis patients want a ... recent online survey* sponsored by Mission Pharmacal Company. The ... Osteoporosis Foundation online support community, revealed that 74 percent ... comes in a form other than a pill or ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
Breaking Medicine Technology:Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... N.J., Oct. 30 Novo Nordisk Inc. announced the ... hemophilia(TM) campaign through a rebranded Web site and ... face many daily challenges, and Novo Nordisk is committed ... a lifetime of possibilities. , These new online resources ...
... GUANGZHOU, China, Oct. 30 ... CHME) ("China Medicine" or "the Company"), a ... pharmaceuticals,traditional Chinese medicines ("TCM"), nutritional and dietary ... announced that through its,wholly-owned subsidiary in China, ...
Cached Medicine Technology:Novo Nordisk is Changing Possibilities in Hemophilia 2Novo Nordisk is Changing Possibilities in Hemophilia 3China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 2China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 3China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: