Navigation Links
Second-line CML drug evokes faster response, fewer side effects, pivotal study finds
Date:6/5/2010

CHICAGO - Dasatanib, a medication currently approved as treatment for drug-resistant chronic myeloid leukemia (CML), provided patients with quicker, better responses as a first therapy than the existing front-line drug, according to researchers at The University of Texas MD Anderson Cancer Center.

The findings were presented at the 46th Annual Meeting of the American Society of Clinical Oncology today, and published in the New England Journal of Medicine. Hagop Kantarjian, M.D., professor and chair of MD Anderson's Department of Leukemia, presented the findings and is the corresponding author on the published study.

Currently, imatinib, or Gleevec , is the approved initial therapy for CML, which has increased the five-year survival rate for the disease from 50 percent to 90 percent, said Kantarjian. However, 30-40 percent of imatinib patients do not achieve confirmed cytogenic complete response (CCyR), or the absence of the defective chromosome that causes the disease, within a year. This benchmark is clearly associated with improvements in long-term outcome, said Kantarjian.

"Previous research conducted at MD Anderson found that more patients taking dasatinib were achieving complete responses more quickly than they do on the current standard of care," said Kantarjian. "In this pivotal Phase III study, we confirmed that dasatinib gets more patients to high-quality remission faster than imatinib, making it a superior front-line therapy. Dasatinib, on average, also has a more favorable side-effect profile."

For the multinational Phase III study, known as DASSIN (Dasatinib versus Imatinib Study In treatment-nave CML patients), 519 newly diagnosed CML patients who had received no prior treatment were randomized to receive either dasatinib, also known as Sprycel , 100 milligrams once daily (259 patients), or imatinib, 400 milligrams once daily (260 patients). CCyR, confirmed on two assessments, was the study's primary
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Second-line CML drugs evoke faster response than front-line therapy
2. Patient age not a factor in use of second-line therapy for lung cancer
3. Cost of Psoriasis Drugs Rising Faster Than Others
4. Faster Heart Rate May Raise Risk of Heart Attack Death
5. Blacks with MS have more severe symptoms, decline faster than whites, new study shows
6. Second Language Comes Faster When Taught in Own Accent
7. 'Get Pregnant' Aims To Help Couples Conceive Naturally, Faster
8. Minimally invasive sports hernia repair may get athletes back in the game faster, study says
9. SAN SnapShot Backup for VMWare - Does Your Backup Always Completes In Seconds, Is 1000x Faster and Costs 90% Less?
10. Cognition declines 4 times faster in people with Alzheimers disease than those with no dementia
11. Alterian Releases Professional Edition of its Content Manager Technology, Offering Partners and Clients an Even Faster Time-to-Live for Their Websites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 2014 Indosoft, Inc., a leading provider of ... it has added support for Sangoma Lyra ... Indosoft have a history of bringing innovative products to ... offers a significant benefit to those using Asterisk as a ... available to users of Q-Suite. , In the past decades, ...
(Date:10/1/2014)... October 01, 2014 QueenBeeTickets.com is giving music ... the singer’s upcoming North American tour, which has him traveling ... come. , Click here to view the selection ... performer’s newest album, is due to come out on October ... shortly thereafter. Bob Seger concert tickets are available for shows ...
(Date:9/30/2014)... in developing countries may have no intention of working ... one fifth of them intend to work in rural ... new study. , Health workforce shortages have been a ... western Africa. The disease initially spread rapidly in rural ... Sierra Leone and Liberia), where health workers are scarcest. ...
(Date:9/30/2014)... HealthDay Reporter TUESDAY, Sept. 30, 2014 (HealthDay ... the brakes on motherhood. And for many young women, that ... research suggests. Women in their early 20s appear most ... economic times. But, according to the new study, that means ... and beyond. The findings suggest that higher unemployment "will ...
(Date:9/30/2014)... 30, 2014 (HealthDay News) -- Sleep apnea is a potential ... points to a possible culprit behind the disorder: a "fat" ... fat deposits are increased in the tongue of obese patients ... co-director of the Sleep Center at the University of Pennsylvania ... , which will publish the findings Oct. 1. Sleep ...
Breaking Medicine News(10 mins):Health News:Indosoft Announces Q-Suite Support For Sangoma Lyra 2Health News:Bob Seger Presale Tickets: QueenBeeTickets.com Delights Fans with Discounted Tickets for All 20 Stops on Seger’s “Ride Out” Tour with The Silver Bullet Band 2Health News:Developing countries should enroll medical and nursing students from rural areas 2Health News:Developing countries should enroll medical and nursing students from rural areas 3Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 3Health News:Could a 'Fat Tongue' Be a Factor in Sleep Apnea? 2
... results with less inconvenience, study finds , WEDNESDAY, Feb. ... breast cancer surgery do just as well with three ... study suggests. , "We consider this [finding] a win-win ... health-care system," said study author Dr. Timothy J. Whelan, ...
... lower Manhattan residents suggest a link, nearly a decade ... 10 years after the 9/11 attacks, residents and workers ... Center site appear prone to persistent, sometimes severe headaches, ... study author Dr. Sara C. Crystal, an instructor in ...
... at the heart of Europe, provides a fitting setting ... Society of Cardiology Council (ESC) on Cardiovascular Nursing and ... its special theme: "Uniting to Improve Cardiovascular Practice". ... developed different ways of managing them. The idea of ...
... , BELGRADE ... www.hirucorporation.com ) and its European subsidiary MindUp BioResearch ( www.mindupbioresearch.com ... Sabera Ruzdijic,s patents. Dr. Sabera Ruzdijic is the project ... team leaders in MindUp Research project are Dr. Nikola Tanic ...
... lead to new vaccines, treatments, researchers say , WEDNESDAY, ... discovered the origin of strains of the AIDS virus ... the origin of the transmitted virus, scientists may be ... to prevent the spread of sexually transmitted HIV," study ...
... connection noted after surgical removal of tumors, study found , ... of the brain boosted levels of spiritual thinking and feeling ... connection between religious attitudes and the physical makeup of the ... 11 issue of Neuron , are based on research ...
Cached Medicine News:Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 2Health News:For Some Breast Cancer Patients, Shorter Radiation Works Well 3Health News:Exposure to 9/11 Fumes Tied to Chronic Headaches 2Health News:Exposure to 9/11 Fumes Tied to Chronic Headaches 3Health News:Nurses unite to improve cardiovascular practice 2Health News:Nurses unite to improve cardiovascular practice 3Health News:Nurses unite to improve cardiovascular practice 4Health News:Nurses unite to improve cardiovascular practice 5Health News:Nurses unite to improve cardiovascular practice 6Health News:MindUp (HIRU) Patents in the World Patent Database 2Health News:MindUp (HIRU) Patents in the World Patent Database 3Health News:Scientists Discover How HIV Is Transmitted Between Men 2Health News:Physical Changes in Brain Linked to Altered Spirituality 2
(Date:9/30/2014)...  According to their CEO, Rob Bohacs ... is going through a complete transformation with highly ... the current clinical trial management process isn,t configured ... trials, which will ultimately drive the prescription cancer ... has been recognized by the National Cancer Institute as ...
(Date:9/30/2014)... -- Alimera Sciences, Inc. (NASDAQ: ALIM ) (Alimera), ... and commercialization of prescription ophthalmic pharmaceuticals, announced today that ... Technology Growth Capital, Inc. (NYSE: HTGC ) ... under the Loan and Security Agreement that Alimera,s subsidiary ... Sciences Limited, entered into with Hercules in April of ...
(Date:9/30/2014)... , Sept. 30, 2014 A study ... (OCT), offered a new look at the composition of ... how physicians understand and treat the disease, a leading ... at Baptist Health Lexington between September 2010 and May ... the Journal of the American College of Cardiology ...
Breaking Medicine Technology:Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2Alimera Sciences Receives $25 Million Advance from Hercules Technology Growth Capital 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... 15, 2011 ULURU Inc. (NYSE AMEX: ... on the development of a portfolio of wound management ... into agreements for investment commitments with Ironridge Global BioPharma ... in two transactions, subject to certain conditions, to purchase ...
... 15, 2011 VIVUS, Inc. (NASDAQ: VVUS ) ... agreement with officials of the Endocrine and Metabolic Division of ... for an early resubmission of the QNEXA New Drug Application ... to seek approval for an initial indication that includes obese ...
Cached Medicine Technology:ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 2ULURU Inc. Enters Into Strategic Financings of Up to $1.6 Million at a Premium to Current Share Price 3VIVUS Provides Regulatory Update on QNEXA 2VIVUS Provides Regulatory Update on QNEXA 3VIVUS Provides Regulatory Update on QNEXA 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: