Navigation Links
Second gene linked to familial testicular cancer
Date:6/29/2009

Specific variations or mutations in a particular can gene raise a man's risk of familial, or inherited, testicular germ-cell cancer, the most common form of this disease, according to new research by scientists at the National Institutes of Health. This is only the second gene to be identified that affects the risk of familial testicular cancer, and the first gene in a key biochemical pathway. The study appears in the July 2009 Cancer Research.

Researchers have suspected for years that heredity plays a role in some patients with testicular germ-cell cancer, although attempts to identify a single gene with very strong effects have been unsuccessful thus far. Scientists currently believe that multiple genes with weaker individual effects--but acting together--probably influence an individual's risk of familial testicular cancer.

Men with a family member who had a testicular germ cell cancer are at three-to six-fold greater risk than other men of developing testicular cancer. Although a family history of testicular cancer probably accounts for less than five percent of all testicular cancers, the careful study of rare familial cancer clusters has often led to important new understanding of the non-familial versions of the same cancer. There will be an estimated 8,400 new cases of testicular cancer diagnosed in 2009 with about 90 percent of them being germ-cell cancers, according to the National Cancer Institute (NCI).

"This study contributes to our understanding of why testicular germ cell cancer appears to run in families," said Raynard Kington, M.D., Acting NIH Director. "The findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ cell cancer."

The key pathway in this disease is the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the cyclic AMP pathway are widely available, and, in the
'/>"/>

Contact: Robert Bock
bockr@mail.nih.gov
301-496-5133
NIH/National Institute of Child Health and Human Development
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Burgeoning Population of Hepatitis C Virus Patients in Need of Second- and Third-Line Treatment Options
2. Medical Services International Maintains Pace in Second Quarter
3. CEOs Need an Advertising Check Up or Second Opinion
4. Trojan(R) Ranks U.S. Colleges and Universities in Second Annual Sexual Health Report Card
5. HealthMedia Revolution Explodes in Second Quarter
6. J.D. Power and Associates Reports: CIGNA HealthCare Recognized for Call Center Customer Satisfaction Excellence For a Second Consecutive Year
7. Acting Surgeon General Announces National Initiatives to Protect Children by Reducing Exposure to Secondhand Smoke
8. Roller Derby Author Cheats Death a Second Time
9. Launch of second European Cancer Research Funding survey
10. Secondhand smoke increases teen test failure
11. Elder Care Author Doctor Marion Launches Second National Tour to Raise Awareness About Aging & Elder Care Issues in America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 Recently, LunaDress.co.uk has updated its blog ... related accessories. Now, all of the models at LunaDress.co.uk come with ... groom lifts the wedding veil can turn out to be a ... A wedding veil can always bring surprise to a wedding. On ... how to choose veils for a big day . , ...
(Date:12/25/2014)... 2014 (HealthDay News) -- Overeating is common during the holidays, ... moderation, an expert says. "Don,t arrive at a party ... you know you,ll be attending a party, but deprivation leads ... dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., said ... healthy during the day and even to have a snack ...
(Date:12/25/2014)... 25, 2014 AngelWeddingDress.com tries its best ... online realm. Today, the business has introduced its new ... prom dress promotion. , The new prom outfits are ... every dress lover. They are specially designed for 2015. ... dresses should visit its website before Jan. 26, ...
(Date:12/25/2014)... December 25, 2014 Plugin creators from ... 5k. A fully customizable business presentation tool made specifically ... the ProFire 5k business tool, users can now display ... CEO of Pixel Film Studios. “ProFire 5k gives users ... to add professionalism to a presentation” , Pixel Film ...
(Date:12/25/2014)... Parker & Sons, Inc. an industry leader when ... regarding heating, cooling and plumbing services in the greater ... “Queen of Clean” for impressive contractor services in Arizona. ... the years for providing outstanding quality customer service and ... for both homeowners and businesses. Linda Cobb, known as ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3
... , ANN ARBOR, Mich., July 24 As the economy ... harder choices about how to spend what money they have, and children ... income bracket -- are more at risk because of it. , ... on Children,s Health taken in May 2009 shows 44 percent of families, ...
... , , ... DVA ), a leading provider of kidney care services for ... its dialysis facilities in Colorado have received the 2009 End Stage ... is granted by the Intermountain ESRD Network (Network 15), a federally ...
... WASHINGTON, July 24 In a Thursday surprise, an ... largest abortion business is set for a Friday vote on the ... http://www.newscom.com/cgi-bin/prnh/20081105/DC44231LOGO ) , ... Parenthood, the nation,s largest abortion chain, of Title X funding in ...
... SACRAMENTO, Calif., July 23 In a last ... a "No" vote on the state budget agreement reached earlier this week ... Branding the budget agreement "morally bankrupt," the 65,000-member UDW specifically targeted ... program: , , , ...
... deemed safe by current clean air standards, can have ... to researchers at the University of California Davis. ... for ozone was recently revised to set lower limits ... for decrements in ozone-induced lung function in healthy young ...
... , SAN FRANCISCO, July 23 ... lesbian, bisexual, and transgender civil rights organization, today announced its ... Saturday, July 25, 2009, at the Westin St. Francis Hotel ... speakers will discuss issues impacting the LGBT community,s strive for ...
Cached Medicine News:Health News:Recession Stressful for Many Kids, Toughest on Poor and Uninsured 2Health News:Recession Stressful for Many Kids, Toughest on Poor and Uninsured 3Health News:Six DaVita Clinics in Colorado Receive Silver Award for Clinical Excellence 2Health News:Six DaVita Clinics in Colorado Receive Silver Award for Clinical Excellence 3Health News:Pence Amendment Passes Rules Committee; Set for Friday Vote 2Health News:UDW Urges 'No' Vote On State Budget; Demands 'Shared Sacrifice' From All Californians 2Health News:Even healthy lungs labor at acceptable ozone levels 2Health News:Human Rights Campaign Announces Speakers at 25th Annual Bay Area Gala 2Health News:Human Rights Campaign Announces Speakers at 25th Annual Bay Area Gala 3
(Date:12/24/2014)... , Dec. 24, 2014  Commonwealth Cornerstone Group (CCG) today ... Credits transaction on Tuesday to help fund the expansion and ... in Sharon . PHN ... Pennsylvania . It is the largest employer in ... than 150 people on staff. Currently, PHN Sharon ...
(Date:12/24/2014)... , Dec. 24, 2014 Kinex Pharmaceuticals announced ... KX2-361 at Roswell Park Cancer Institute. KX2-361 ... drug that has shown potent inhibitory activity against a ... that are resistant to Temozolomide (T98G), the most widely ... a well-established brain tumor mouse model, KX2-361 consistently clears ...
(Date:12/24/2014)... International Trade Commission (ITC) issued its final decision in the ... notice issued on December 23, the ITC ruled in favor ... was invalid. BMC President, James Xu ... with the ITC,s decision in this case. This victory for ... very beginning on the key patents in the case. ResMed ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2
... procedure ... ... that four presentations at the Heart Rhythm Society,s 2008,Scientific Sessions reported ... findings aligned well with each,other and supported previous experience from the ...
... increased FDA scrutiny,around new medicines and heightened competition ... science staff have to be even,more delicate when ... With less products making it through development,communications for ... on to favorably impact,launch success. Marketers see coordination ...
Cached Medicine Technology:Presentations From Recent Heart Rhythm Society Meeting Validate the Safety and Efficacy of Ablation Frontiers Technology in 230 Patients 2Presentations From Recent Heart Rhythm Society Meeting Validate the Safety and Efficacy of Ablation Frontiers Technology in 230 Patients 3New Pharma Business Model Increases Pressure on Staff Communicating Trial Data 2
The original Zeppelin High-Speed Motordrill System has been developed to rapidly cut bone, plastic and metal with utmost precision. 120-150 psi - 90.000 rpm - 90g - autoclavable at <134 C....
... The Black Max is a ... for the rapid dissection of ... The Black Max not only ... also allows for the control ...
Legend Gold is the most powerful of the new motors. It runs at an impressive 76,000 rpm at 120 psi/8 bar. It is also smaller than the Midas Rex Classic motor, with an enhanced ergonomic design....
... Gold Touch motor is the first true high-speed, ... Gold Touch is comparable to Legend Gold and ... The telescoping lever design provides ergonomic positioning and ... Midas Rex Classic, the Legend Gold Touch is ...
Medicine Products: