Navigation Links
Second door discovered in war against mosquito-borne diseases
Date:7/8/2013

EAST LANSING, Mich. -- In the global war against disease-carrying mosquitoes, scientists have long believed that a single molecular door was the key target for insecticide. This door, however, is closing, giving mosquitoes the upper hand.

In this week's Proceedings of the National Academy of Sciences, a team of researchers led by Michigan State University has discovered a second gateway that could turn the tide against the mosquitoes' growing advantage.

For many years, pyrethroid insecticides have been deployed in developing countries to fend off diseases such as malaria, dengue fever and more. They're so effective that they are the only insecticides the World Health Organization uses with their mosquito nets they distribute around the globe.

"Pyrethroids are effective because they eliminate mosquitoes while having few if any side effects on humans," said Yuzhe Du, MSU electrophysiologist and one of the lead authors. "Our discovery of a second receptor in the mosquitoes' sodium channel gives us a better understanding of how the insecticide works at a molecular level as well as could lead to ways to stem mosquitoes' resistance to pyrethroids."

Receptors on sodium channels act as doorways. Pyrethroids work by propping open the sodium channel. Mosquitoes don't die from the toxin, per se. They die from sodium overdose. With the door jammed wide open, their cells gulp down sodium, which overexcites their nervous system and eventually leads to paralysis and death.

In the last decade, growing resistance in mosquitoes has been detected in many countries. At the molecular level, resistance appears as mutations in the primary receptor in the sodium channel that allow mosquitoes to survive exposure to the insecticide. The discovery of the second receptor in the sodium channel, however, opens up more avenues to increase pyrethroids' effectiveness.

"One of the keys to the success of this research was our cloning of a mosquito sodium channel for the first time," said Ke Dong, MSU insect toxicologist and neurobiologist and the paper's senior author. "Another lead author of this study, Yoshiko Nomura, dedicated nearly one year to make this happen, which allowed Dr. Du to perform electrophysiological experiments with the clone."

The team then spent nearly two years to discover the new pyrethroid-binding site, she added.

The revelation not only explains much of pyrethroid resistance found in mosquito populations worldwide, but also helps answer why they affect insects but not humans and other mammals. Since this is a growing issue with cockroaches, bedbugs, fleas, potato beetles and other crop pests, the discovery could lead to benefits for the pest-control industry and farming.

"Our finding may ultimately improve global prediction and monitoring of pyrethroid resistance in mosquitoes and other arthropod pests," Dong said. "It could have broad impacts in agriculture and medicine that affect people's lives, especially in developing countries."


'/>"/>

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Related medicine news :

1. Donor Kidney Re-Used in Second Patient After Failing in First
2. Secondhand smoke continues to vex children with asthma
3. Many Asthmatic Kids Harmed by Secondhand Smoke: Study
4. UMD team gives drug dropouts a second chance
5. First, Second Kidney Transplants Have Similar Success: Study
6. Secondhand Smoke May Harm Heart Function
7. Study Ties Secondhand Smoke to Bladder Irritation in Kids
8. A second victim comes forward in the sexual assault charges filed against Dr. Mike Adam.
9. Secondhand Smoke Linked to Raised Diabetes Risk
10. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
11. Newer Second-Line Diabetes Drug May Outperform Older Meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine named Herr the “Leader ... biomechatronics, technology that marries human physiology with electromechanics. He continues that work as Director ... Founder of BionX , a leader in the field of prosthetic devices. , ...
(Date:4/28/2016)... ... April 28, 2016 , ... One way to ignore ... This is unfortunately true. But we toss the baby out with the bathwater when ... provides tips for identifying higher-quality studies and otherwise making better use of education policy ...
(Date:4/28/2016)... AZ (PRWEB) , ... April ... ... the AnzuMedical™ Knowledge Sharing and Collaboration Platform™ , today announced a ... platform will provide efficient access to medical knowledge, educational resources, and a ...
(Date:4/28/2016)... ... April 28, 2016 , ... Accreditation ... Community Oncology Pharmacy Association (COPA) to develop a comprehensive Specialty Pharmacy Accreditation with ... introducing an accreditation distinction. ACHC provides a wide range of pharmacy accreditation services ...
(Date:4/28/2016)... , ... April 28, 2016 , ... Denise McCormick Baich had written poetry dating back ... poetry arrived again much like a tsunami and took on a more spiritual tone. The ... encouraged her to do more with it than just file it away. Friends would ask ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... New York , April 27, 2016 ... market report titled, "Skincare Devices Market - Global Industry ... 2023." According to the report, the global skincare devices ... and is anticipated to expand at a CAGR of ... Mn in 2023. Browse the full Skincare Devices ...
(Date:4/27/2016)... Research and Markets has ... Disposables Market 2016-2020"  report to their offering.  ... global anesthesia disposables market is set to ... the period 2016-2020.  Healthcare-acquired infections ... safety. Organizations like the CDC and Public ...
(Date:4/26/2016)... 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) is ... , Pharm D., to Vice President of Education and ... Hagerman will continue to lead and oversee Diplomat University, ... education and training to Diplomat employees and external professionals ... University also houses the quality assurance department, which focuses ...
Breaking Medicine Technology: