Navigation Links
Second Ohio State cancer drug begins clinical trials testing
Date:6/18/2010

COLUMBUS, Ohio For the second time within a year, an experimental drug invented by cancer researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) is being tested on patients in a clinical trial.

This week, adult patients began receiving doses of the potentially groundbreaking drug, which is designed to treat relapsed or treatment-resistant multiple myeloma, chronic lymphocytic leukemia or lymphoma, said Dr. John Byrd, associate director of clinical translational research at OSUCCC-James and a leukemia specialist who initiated the drug's development with Ching-Shih Chen, an Ohio State cancer researcher and medicinal chemist.

The new phase I/IIa clinical trial will assess the safety and initial evidence of activity of the oral drug AR-42, which belongs to a new class of drugs called histone deacetylase (HDAC) inhibitors compounds designed to reactivate genes that normally protect against cancer but are turned off by the cancer process. Ohio State is the only site worldwide accepting patients to the clinical trial, said Byrd.

"Early tests in cancer cell models showed that AR-42 is 10,000 fold more potent than the starting/parent agent," said Chen, a professor of pharmacy, urology and internal medicine who holds the Lucius A. Wing chair of cancer research.

In 2003, Byrd asked Chen to try to improve the potency of a short-chain fatty acid known to have a weak inhibitory effect against cancer growth. Chen worked with cancer center and pharmacy colleagues at Ohio State to develop the drug originally called OSU-HDAC42, a broad spectrum histone and non-histone deacetylation inhibitor (pan-DAC).

The agent has been licensed to the biopharmaceutical company Arno Therapeutics, Inc., for clinical development.

"It is exciting to see this very potent broad class I/II HDAC inhibitor enter the clinic for treatment of blood cancers and we look
'/>"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. American Doctor Misses World Cycling Record by 4 minutes, 57 Seconds
2. Smoke-free air laws effective at protecting children from secondhand smoke
3. Second-line CML drugs evoke faster, better front-line remissions
4. Second-line CML drug evokes faster response, fewer side effects, pivotal study finds
5. Career Training College, Pima Medical Institute, Offering Second Bachelor's Degree Program in Respiratory Therapy
6. BioConference Live Announces Speakers and Sponsors for Second Edition of Premier Online Conference for Life Science Community
7. Smoking Ups Risk of Second Breast Cancer
8. Cambridge Healthtech Institute to Host Its Second Annual Collaborative Innovation in Biomedicine Conference
9. Second volume of groundbreaking Emerging Model Organisms series is released
10. Second AGA Foundation/Bernard Lee Schwartz Foundation Research Scholar Award presented
11. Secondhand Smoke Boosts Sinusitis Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 ... networking and relationship-marketing firm, announced today the ... Executive® and Project of the Year Awards ... makers representing organizations in financial services, commercial, ... large-scale technology endeavors that address key issues ...
(Date:10/1/2014)... October 01, 2014 Beverly Hills licensed ... Mojas is celebrating 20 years of private practice in ... of people to achieve greater joy and fulfillment in ... of warning signs and suggestions for anyone who suspects ... explains: “Believe it or not, it’s not always ...
(Date:10/1/2014)... 01, 2014 NoteSwift Inc., announced today ... 10.0, 12.1 and 13.0. NoteSwift is the bridge between ... to navigate and document clinical information at the point ... creating a patient note by more than half – ... major pain points providers state impedes EHR use according ...
(Date:10/1/2014)... in Bahir Dar, Ethiopia, at the occasion of ... gathered some 150 African and international leishmaniasis experts, ... safety and efficacy monitoring plan, carried out ... Sudan, Uganda, and Ethiopia, were presented to key ... to treatment of kala-azar with the combination of ...
(Date:10/1/2014)... Dr. Saj Jivraj, one of the ... traveling to Chennai, India, tomorrow to speak at the ... 3. , Dr. Jivraj is founder of the Anacapa ... and one of the world’s foremost prosthodontists, meaning he ... is speaking to the Indian Society of Oral Implantologists ...
Breaking Medicine News(10 mins):Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 3Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 5
... By Steven Reinberg HealthDay Reporter , WEDNESDAY, ... they have found a correlation between asthma and lung cancer ... a correlation between chronic obstructive pulmonary disease (COPD) and lung ... has been shown for asthma and lung cancer, the researchers ...
... the association for informatics professionals, has been selected to ... National Priorities Partnership (NPP), beginning Sept. 21, 2010. ... Quality Forum (NQF) will reconstitute the NPP, which currently ... U.S. health care system. The NPP,s previous work has ...
... Nov. 3, 2010 The U.S. Department of Veterans Affairs ... the highest honor it bestows on scientists. Lee, ... of Orthopaedic Surgery, will receive $1.4 million to support his ... VA Medical Center. "Dr. Lee is one of the ...
... the demand for organically produced food increasing, scientists are ... potatoes generally do not have higher levels of healthful ... fertilizers and pesticides. Their study appears in ACS, bi-weekly ... In the study, Pia Knuthsen and colleagues point out ...
... HealthDay Reporter , TUESDAY, Nov. 2 (HealthDay News) -- The ... job of properly monitoring the safety of medical devices, the ... the authority to approve both drugs and medical devices, but ... and safety is lax in both its initial approval of ...
... and Research Center at the University of California, San ... compounds may be effective in treating both alcohol and ... a paper published in the November 3, 2010 issue ... consumption in rodents was significantly decreased by two compounds ...
Cached Medicine News:Health News: Asthma Linked to Lung Cancer Risk in Study 2Health News:National Quality Forum picks AMIA for national priorities partnership 2Health News:VA names UCI orthopedic biomedical engineer a senior research career scientist 2Health News: FDA Failing to Monitor Safety of Medical Devices: Report 2Health News: FDA Failing to Monitor Safety of Medical Devices: Report 3Health News: FDA Failing to Monitor Safety of Medical Devices: Report 4Health News:New compounds may treat both alcohol and cigarette addictions 2
(Date:9/30/2014)... STUDY OBJECTIVES The objective of ... an overview of the current and future characteristics ... key objective is to present a comprehensive analysis ... important tool in the treatment of various diseases. ... within the protein therapeutics market, which includes peptide ...
(Date:9/30/2014)...  Decision Resources Group finds that the Asia Pacific ... China , India , ... through 2023. Dental implant procedure volumes will grow as physicians are ... Other key findings from Decision Resources Group,s coverage of the ... , Dental implant penetration: Penetration of dental implants among the ...
(Date:9/30/2014)... LOS ANGELES , Sept. 30, 2014   ... apnea shopping destination , today announced that it now ... ResMed . AirSense CPAPs are the first sleep apnea ... makes it simple and easy to track and share ... the overall effectiveness of their CPAP therapy.  In addition, ...
Breaking Medicine Technology:Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4
... SANTA CLARA, Calif., Oct. 28 Cell Biosciences, Inc. ... Alpha Innotech Corp. (OTC Bulletin Board: APNO). The stockholders ... regulatory and other conditions have been satisfied. Pursuant to ... Alpha Innotech stockholders will receive $1.50 per share, or ...
... , NEWTOWN SQUARE, Pa., Oct. 28 Recent news ... influenza inoculations) have been widespread. The shortage of the ... to increased interest in homeopathic Influenzinum. , The American ... and distributors of homeopathic drugs, wishes to inform the ...
Cached Medicine Technology:Confusion over Influenzinum Clarified by the American Association of Homeopathic Pharmacists (AAHP) 2
... / gel tubes are for the ... diagnostics and for viral load determinations. ... remain stable at room temperature for ... results, it is recommended to centrifuge ...
BD Vacutainer® spray-coated K2EDTA tubes are used for whole blood hematology determinations and immunohematology testing....
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
We offer small and large pre-gelled Surface Electrodes suitable for EMG or EGG recordings....
Medicine Products: