Navigation Links
Second Ohio State cancer drug begins clinical trials testing
Date:6/18/2010

COLUMBUS, Ohio For the second time within a year, an experimental drug invented by cancer researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) is being tested on patients in a clinical trial.

This week, adult patients began receiving doses of the potentially groundbreaking drug, which is designed to treat relapsed or treatment-resistant multiple myeloma, chronic lymphocytic leukemia or lymphoma, said Dr. John Byrd, associate director of clinical translational research at OSUCCC-James and a leukemia specialist who initiated the drug's development with Ching-Shih Chen, an Ohio State cancer researcher and medicinal chemist.

The new phase I/IIa clinical trial will assess the safety and initial evidence of activity of the oral drug AR-42, which belongs to a new class of drugs called histone deacetylase (HDAC) inhibitors compounds designed to reactivate genes that normally protect against cancer but are turned off by the cancer process. Ohio State is the only site worldwide accepting patients to the clinical trial, said Byrd.

"Early tests in cancer cell models showed that AR-42 is 10,000 fold more potent than the starting/parent agent," said Chen, a professor of pharmacy, urology and internal medicine who holds the Lucius A. Wing chair of cancer research.

In 2003, Byrd asked Chen to try to improve the potency of a short-chain fatty acid known to have a weak inhibitory effect against cancer growth. Chen worked with cancer center and pharmacy colleagues at Ohio State to develop the drug originally called OSU-HDAC42, a broad spectrum histone and non-histone deacetylation inhibitor (pan-DAC).

The agent has been licensed to the biopharmaceutical company Arno Therapeutics, Inc., for clinical development.

"It is exciting to see this very potent broad class I/II HDAC inhibitor enter the clinic for treatment of blood cancers and we look forward to generating meaningful clinical results from in this Phase I/IIa study," said Byrd. "We are incredibly grateful to organizations that have supported this effort to bring this drug forward to our blood cancer patients.

Dr. Michael Caligiuri, director of Ohio State's Comprehensive Cancer Center and chief executive officer of the James Cancer Hospital and Solove Research Institute, praised the collaborative efforts of Ohio State researchers who worked more than 7 years to develop this drug.

"We are encouraged by its preclinical activity, and feel that this molecule could have meaningful clinical implications in a variety of cancers," said Caligiuri.

Dr. Michael Grever, chairman of the department of internal medicine at Ohio State and co-leader of the Experimental Therapeutics program at OSUCCC-James, was instrumental in moving this experimental agent from bench to bedside.


'/>"/>

Contact: Eileen Scahill
Eileen.Scahill@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. American Doctor Misses World Cycling Record by 4 minutes, 57 Seconds
2. Smoke-free air laws effective at protecting children from secondhand smoke
3. Second-line CML drugs evoke faster, better front-line remissions
4. Second-line CML drug evokes faster response, fewer side effects, pivotal study finds
5. Career Training College, Pima Medical Institute, Offering Second Bachelor's Degree Program in Respiratory Therapy
6. BioConference Live Announces Speakers and Sponsors for Second Edition of Premier Online Conference for Life Science Community
7. Smoking Ups Risk of Second Breast Cancer
8. Cambridge Healthtech Institute to Host Its Second Annual Collaborative Innovation in Biomedicine Conference
9. Second volume of groundbreaking Emerging Model Organisms series is released
10. Second AGA Foundation/Bernard Lee Schwartz Foundation Research Scholar Award presented
11. Secondhand Smoke Boosts Sinusitis Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... New Jersey (PRWEB) , ... February 11, 2016 , ... ... to a free CEU seminar titled, “Stroke Management: Time to Act, Time to Heal” ... Housing Community in Whippany, N.J. The presenter is Vishal Chedda, president of ANSA ...
(Date:2/11/2016)... ... February 11, 2016 , ... The president released a ... Health System but would shift more of the cost burden to military beneficiaries. ... laid out in the defense budget as including limited quantifiable benefit fixes mixed with ...
(Date:2/11/2016)... ... February 11, 2016 , ... In a new ... plastic surgeon , Dr. Rod J. Rohrich, and colleagues, examine and underscore the ... recommendations for rhinoplasty surgeons when addressing this vital area. , The upper lateral ...
(Date:2/11/2016)... ... February 11, 2016 , ... PharmMD CEO ... Garrett will focus on contract negotiations, corporate strategy and healthcare data law. Additional ... best practices in data breaches for the Part D Star Rating improvement and ...
(Date:2/11/2016)... ... 11, 2016 , ... Talix today announced that Clive Fields, ... presenting at the 2016 HIMSS Annual Conference & Exhibition, taking place February 29 ... “ Coding for Care: Using Data Analytics for Risk Adjustment ,” Dr. Fields ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 Brain Cancer ... treatment method at West Cancer Center . ... fields to inhibit cancer cell replication causing death of ... than a decade to show a significant extension in ... (GBM) patients. Currently, West Cancer Center is the only ...
(Date:2/11/2016)... , Feb. 11, 2016  AbbVie, a ... AbbVie Rheumatology Scholarship, designed to provide financial support ... as they pursue higher education goals. Fifteen scholars ... the 2016-2017 school year. The AbbVie Rheumatology Scholarship ... Haas , vice president, corporate social responsibility, brand ...
(Date:2/11/2016)... 11, 2016 PLAD, Inc. (OTC Pink: PLAD) is ... sales exceeding company targets, are adding key personnel to ... from the United States Patent and Trademark Office for ... Executive Officer of PLAD, Inc.  In January, PLAD established ... with two new customers, Cumberland Goodwill EMS ...
Breaking Medicine Technology: