Navigation Links
Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies
Date:3/3/2010

eutralizing antibodies against both naturally occurring and injected AAV, but these antibodies did not prevent the injected gene from producing the desired enzyme." High is director of the Center for Cellular and Molecular Therapeutics (CCMT) at Children's Hospital, which manufactured the vector used in the current study and the previous human trial for LCA.

In the human trial for LCA reported last year, the CHOP/Penn researchers, led by Bennett, High and retina specialist Albert M. Maguire, M.D., injected the vector into only one eye in each of their 12 patients. Because the treatment was experimental, researchers left one eye untreated in the event of unexpected complications. After the subjects experienced partially restored eyesight in their treated eyes, many were eager to receive the same treatment in the other eye. The current study advances that possibility, and the research team is planning another clinical trial of LCA gene therapy, which may include some of the subjects from the first group.

Additionally, the results may set the stage for gene therapy in LCA patients who were excluded from the previous trial. Adopting a conservative approach, the researchers did not treat patients who already had neutralizing antibodies against AAV in their blood. As many as a quarter of all people may carry these antibodies by their teenage and young adult years. Fortunately, unlike other organs, both human and animal eyes are insulated from these circulating antibodies. (Co-author

SOURCE The Children's Hospital of Philadelphia
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Patient age not a factor in use of second-line therapy for lung cancer
2. Secondhand Smoke Starts Damaging Arteries in Childhood
3. Unilens Vision Reports Record Second Quarter Earnings And Royalty Income
4. Board Certified Renal Specialist, Nina Kolbe, Publishes Second Edition of Kidney Health Gourmet: A Diet Guide and Kidney Friendly Recipes for People Not on Dialysis
5. Second Language Comes Faster When Taught in Own Accent
6. Biotel Announces Results for Second Quarter ended December 31, 2009
7. Researchers discover second protective role for tumor-suppressor
8. United American Healthcare Corporation Announces Fiscal 2010 Second Quarter Results
9. Research finds hazards from secondhand smoke in bars and restaurants
10. Exposure to secondhand smoke among children in England has declined since 1996
11. Boy Scouts of America Prepared for Second Century of Service
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... PhUSE is proud to announce Dr. Pritpal Tamber, ... speakers for their 10th annual conference which is themed ... in 2013 , Charles Sabine in 2012 ... again presents high-calibre speakers to talk about relevant topics ... information. , Dr. Pritpal Tamber is a "health explorer" ...
(Date:9/21/2014)... NY (PRWEB) September 21, 2014 The ... help businesses and manufacturers perform tests on items ranging ... an increasingly regulated society, pressure on operators to ensure ... than ever. A greater number of government safety regulations ... manufacturers' goods prior to sale. Although revenue briefly dipped ...
(Date:9/21/2014)... The asthma market saw very slow ... become saturated with relatively efficacious standard therapies, such ... corticosteroids and long-acting beta-agonists (ICS/LABAs), and leukotriene modifiers, ... However, the launch of seven novel targeted biologic ... by the next-generation inhalers will strongly drive the ...
(Date:9/21/2014)... New York (PRWEB) September 21, 2014 ... continue to move forward in Pennsylvania’s Philadelphia Court ... to court documents, the proceeding’s next monthly meeting ... Litigation, case number 100300296) , “Our Firm is ... Risperdal lawsuits in this litigation. We are pleased ...
(Date:9/21/2014)... 2014 Discount-Dress.com, a company ... recently announced its decision to implement a new shopping ... for ladies across the world. Furthermore, the company has ... ladies. , The new items come in fashionable ... prices, up to 56 percent off. "We are happy ...
Breaking Medicine News(10 mins):Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 2Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 3Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 4Health News:Discount-Dress.com Implements A New Shopping Cart Software And Provides New Beach Wedding Dresses 2
... recent survey organized by women’s magazine, Grazia reported the interest ... results reported that an overwhelming half of the interviewed women ... survey was reported in Daily mail. , ,The study ... of 34 years, residing in England, Scotland and Wales. The ...
... A study conducted in the Department of Medicine at ... // regular sunscreen routine in childhood can reduce the ... ,"Sunscreen has always been an important part of ... reduce the number of sunburns, especially for children," said ...
... been associated with sudden onset of phases// of habitual ... ,The Mayo Clinic psychiatrists were behind the research that ... and the drug called dopamine agonists. ,Parkinsons disease ... its symptoms are muscle tremors, muscle rigidity, decreased mobility, ...
... Scientists in a major breakthrough in the study of treating ... with gain in weight. ,This now explains why people ... and turn obese. The logical sequence for obesity is input ... certain situations this is not the case. ,The answer ...
... immune deficiency syndromes, and researchers// have been able to ... immune deficiency conditions called immunoglobulin A (IgA) deficiency and ... be hereditary or acquired. Hereditary or primary immune deficiency ... and tissues that are responsible for our immune system, ...
... has recently issued a warning regarding the consumption of Liqiang ... drug that could have serious, life-threatening consequences in some people. ... of the potential problem through an anonymous consumer complaint which ... glyburide in the product. ,Glyburide is a drug ...
Cached Medicine News:Health News:Use Of Sunscreen In Childhood And Prevents Future Skin Cancer 2
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Alere Inc. ... rapid diagnostics, issued the following statement today in support ... Antibiotic-Resistant Bacteria. "As the global leader in ... for establishing a national strategy to address the serious ... to work with the Administration on initiatives to promote ...
(Date:9/19/2014)... 19, 2014  Lpath, Inc. (NASDAQ: ... therapeutics, announced today that it has entered into ... common stock and 3,605,042 unregistered warrants in a ... one registered share of common stock and one ... common stock will be $3.475.  The warrants have ...
(Date:9/19/2014)... , Sept. 19, 2014  The body of ... the publication of two papers this past week.  The ... Head and Neck Surgery , finds that withholding ... subjective measures of sleep disordered breathing, leading the paper,s ... in obstructive sleep apnea severity and improvement of quality ...
Breaking Medicine Technology:Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4
... BEDFORD, Mass., Dec. 3 MicroCHIPS, a developer of ... named a 2010 Technology Pioneer by the World Economic ... pioneering a novel medical device platform that uses patented, ... monitoring and treatment. MicroCHIPS, technologies have broad applicability, ...
... , MAPLE GROVE, Minn., Dec. 3 ... its strategic plan for central nervous system (CNS) diseases with ... management of epilepsy. USL255 is being developed with Upsher-Smith,s proprietary ... in early 2010 for the adjunctive treatment of epilepsy patients ...
Cached Medicine Technology:MicroCHIPS Named 2010 Technology Pioneer by World Economic Forum 2Upsher-Smith Announces Milestone in Development of CNS Strategy 2
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
... Many special order products are offered as ... long lengths. The modular instruments may be ... options such as ratchets, insulation and flush ... Mediflex stock. Customer specifications may affect delivery ...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
... widest offering of single-use instruments on the market., ... lengths for Bariatric Surgery. , Dual action ... covers the pivot points to reduce the chance ... universal cord, which eliminates gapping at connection and ...
Medicine Products: