Navigation Links
Seattle-based PhenoPath Laboratories Retests Nearly 3,000 Breast Cancer Specimens from Quebec Breast Cancer Inquiry

Seattle-based PhenoPath Laboratories retested nearly 3,000 breast cancer specimens from the Province of Quebec following an inquiry that suggested that there might have been testing errors resulting in incorrect treatment of some patients.

(PRWEB) December 20, 2009 -- Seattle-based PhenoPath Laboratories served as the reference laboratory for a highly anticipated retesting of nearly 3,000 breast cancer specimens from the Province of Quebec, results of which were announced by Quebec Health Minister Yves Bolduc this week.

The review had been requested after Quebec's Association of Pathologists released a startling report in April 2009 of a limited study that had suggested a high error rate, of between 15% and 20%, in the determination of the estrogen receptor (ER) status, an important test for the determination of appropriate treatment of breast cancer patients. In recent years, there have been other disclosures of high error rates in breast cancer testing in other provinces of Canada, including Newfoundland/Labrador, Manitoba, New Brunswick, and Ontario. Quebec is the fifth province in Canada to uncover inaccuracies in breast cancer testing.

All breast cancers from patients in North America are tested for the presence of ER, as patients with breast cancers that are ER positive generally have a more favorable outcome than those that are ER negative, and such patients can also be successfully treated with drugs such as tamoxifen.

PhenoPath Laboratories was selected to retest a total of 2,856 cases that had been originally analyzed at many laboratories in Quebec between April 1, 2008 and June 1, 2009. The retesting involved a technique called immunohistochemistry (IHC), a special technique in which tumor tissue prepared from the original biopsies can be viewed under the microscope and evaluated for the presence of ER. PhenoPath Laboratories was founded in 1998 by Dr. Allen M. Gown, an internationally recognized expert in the technique of IHC, and the laboratory has become a highly respected national reference laboratory for the performance of IHC and other specialized pathology testing of breast and other tumors. The laboratory was involved in a landmark study published in December 2006 demonstrating that reagents employed for the identification of ER in breast cancer specimens at PhenoPath Laboratories were significantly more sensitive and specific than those widely used in the United States and around the world. PhenoPath’s vast experience and expertise with IHC in this context was a major factor in the selection of this laboratory by the Province of Quebec for this retesting.

In the re-analysis, results of which were just announced, a total of 87 women were found to have received a false negative result from the original pathology laboratory tests in Quebec. Of this number, 39 were required to alter their treatment and among them five women died. Minister of Health Yves Bolduc said it was impossible to determine whether the women died as a result of being improperly treated.

Despite the relatively low rate of “false negative” ER tests revealed by the PhenoPath Laboratories retesting of the original Quebec laboratory results, given the absence of standardization and comparable retesting studies in the United States, and the additional potential sources of error not addressed in this retesting, the error rate in ER testing in breast cancer in laboratories the United States remains uncertain.

About PhenoPath Laboratories:
PhenoPath Laboratories is a national anatomic pathology reference laboratory located in Seattle, Washington. PhenoPath provides consultation services and diagnostic and research applications of immunohistochemistry (IHC), flow cytometry, FISH, CISH and PCR testing to pathologists and clinical laboratories across the United States and the world.

Contact Information:
Allen M. Gown, M.D.
PhenoPath Laboratories, 551 North 34th Street, Suite 100, Seattle, WA 98103-8675
Telephone: 206-374-9000, 888-927-4366, FAX 206-374-9009



Read the full story at

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Related medicine news :

1. Covance to Acquire Seattle-Based Gene Expression Laboratory from Merck & Co., Inc.
2. Seattle-Based Marsha Rivkin Center for Ovarian Cancer Research Appoints Nancy Sclater, Executive Director
3. Seattle-Based Law Firm Williams Kastner Receives Significant Defense Verdict in Trade Secret Business Litigation Case
4. Upscale Seattle-Based Skincare Clinic Expands Into California With Unique Custom Tailored Skincare Approach
5. BioMosaics Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer
6. Roxane Laboratories, Inc. Announces the Launch of Perindopril Erbumine Tablets
7. Renewal Laboratories(TM) Announces the First Omega3 Supplement Water for Cardiac Health
8. Reportlinker Adds Whos Doing What in Molecular Diagnostics? - Kalorama / Emmes Survey of US Laboratories Report
9. Caraco Pharmaceutical Laboratories, Ltd. Announces Resignation of Georges Ugeux from Board of Directors
10. Caraco Pharmaceutical Laboratories, Ltd. Announces Appointment of F. Folsom Bell to Board of Directors
11. ARUP Laboratories Scientist Tanya Sandrock Receives NIH Grant to Search for Additional HIV Therapies
Post Your Comments:
(Date:11/25/2015)... MN (PRWEB) , ... November 25, 2015 , ... Finnleo, ... through Christmas Eve on several models of traditional and far-infrared saunas. , ... Nordic Spruce is the most traditional Finnish sauna wood, and Finnleo uses only European ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director at ... hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for safety ... fuller hair, without the need for surgery, prescription pills, or topical foams. , ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, ... Two Organizations, One Beat ” campaign. The partnership between the two groups began in ... in MAP International’s cause. , MAP International was founded in 1954 and is an ...
(Date:11/25/2015)... ... 2015 , ... Dental professionals who would like to become more proficient on ... Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. Courses will be held on ... co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and Dr. D’Orazio are proud to ...
(Date:11/25/2015)... IL (PRWEB) , ... November 25, 2015 , ... The ... announce a recent successful appellate decision obtained by Attorneys Francisco J. Botto and Alex ... Adcock v. Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (NASDAQ: KTOV ) (TASE: KTOV), a biopharmaceutical company ... simultaneous treatment of various clinical conditions, today announced the ... 3,158,900 American Depository Shares ( ADSs ), each representing ... purchase up to 3,158,900 ADSs. The ADSs and warrants ...
(Date:11/25/2015)... Nov. 25, 2015 Allergan plc (NYSE: ... and Rugen Therapeutics, a start-up  biotechnology company focused ... CNS disorders and funded by the F-Prime Biomedical ... entered into an exclusive collaboration to support the ... Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... TEL AVIV, Israel , November 25, 2015 /PRNewswire/ ... firms (the "New Investors"), pursuant to which BioLight and ... in BioLight,s IOPtima Ltd. subsidiary ("IOPtima") via a private ... global commercialization of its innovative IOPtimate™ system used in ... a regulatory approval pathway process for the IOPtimate™ system ...
Breaking Medicine Technology: