Navigation Links
Seattle Children's lands major funding with hopes of saving thousands of infant lives
Date:8/16/2011

SEATTLE August 16, 2011 Seattle Children's Research Institute today announced the receipt of a two-year, $2.3 million grant from the Bill & Melinda Gates Foundation to complete prototype development of its new respiratory support device, called Seattle Children's Positive Airway Pressure (Sea-PAP.) Sea-PAP, designed to be an affordable and simple Bubble Continuous Positive Airway Pressure (B-CPAP) device, will provide breathing support to premature infants who suffer from respiratory distress. Upon completion, Sea-PAP will be significantly cheaper to produce, operate, and maintain than other ventilators and respiratory support devices.

Children's expects the affordability of Sea-PAP will lead to rapid adoption in the developing world and beyond. The simple design shrinks the cost to a fraction of the $30,000 price tag for conventional ventilators, making Sea-PAP and its life-saving therapy accessible to healthcare systems that lack the resources to purchase and operate complex, expensive equipment.

"The worldwide need for low-cost, safe, and easy to use respirator technology is clear. Many premature infants who require only basic assistance with their breathing die for a lack of a simple, affordable alternative to expensive ventilators," said Charles V. Smith, PhD, Director of the Center for Developmental Therapeutics at Seattle Children's Research Institute, and co-inventor of Sea-PAP. "Sea-PAP's low cost and ease of use will make it accessible to all."

More than four million infants worldwide die each year, and one million of those deaths are attributed to respiratory insufficiency, suffocation due to underdeveloped lungs. These deaths are largely attributed to the lack of respiratory support devices in resource-limited countries. Children's estimates that Sea-PAP could save the lives of many thousands of these babies each year, if broadly adopted.

"Cost of technology should not be the deciding factor for which life is saved. Sea-PAP will provide more communities, even in the most rural areas, with the tools to save premature infants with respiratory distress," said Thomas N. Hansen, MD, CEO at Children's and co-inventor of Sea-PAP. "If we could even make a dent of a few percentage points in infant mortality rates, the impact would be staggering."

Preterm birth is the 7th leading U.S. healthcare expenditure today, costing approximately $26 billion a year. A simple tool like Sea-PAP could also help address the financial burden that prematurity brings to care.

Benefits of Simplified Technology and Other Key Differentiators

What differentiates Sea-PAP from most other respiratory support devices is that it is simpler to assemble and maintain, thus enabling a low cost of ownership. To build and operate Sea-PAP, only a small tool kit of supplies are needed, including a continuous air supply, a breathing circuit tube, a tube for the nose, water, and a competent human operator. The breathing and nose tubes can be used multiple times, if sterilized.

Sea-PAP works like conventional B-CPAP devices providing a continuous flow of air via tubes inserted in an infant's nostrils. Sea-PAP's key differentiator from other B-CPAP devices is that its breathing circuit tube is placed in water at a 135 degree slope, which creates fluctuations in the positive airway pressure. These fluctuations keep the lungs open, which lessens the work required from respiratory muscles, thus making it easier to breathe.

Respiratory muscle exhaustion is a major cause of failure in conventional B-CPAP therapy. These failures often necessitate the need for tracheal intubation, mechanical ventilation, and exposure of the infant to high concentrations of oxygen, which carry the risk of tissue damage, infection, and inflammation - all of which are major factors in the development of chronic lung disease. By reducing the work that an infant has to do to breathe, Sea-PAP will eliminate the need for tracheal intubation and mechanical ventilation in many infants.

"Removing the cost barriers of life saving respiratory support technology ensures more infants have a chance at a healthy life," said Gary Darmstadt, Director of Family Health at the Bill & Melinda Gates Foundation. "We are excited for the completion of Sea-PAP, as we believe it will have a significant impact on reducing infant mortality rates worldwide."

Commercialization Timeline and Continued Development Plans

Children's expects to complete development of Sea-PAP in 2012, and for commercial distribution to begin in 2013.

Ongoing development will be led by Dr. Hansen, Dr. Smith, and C. Peter Richardson, PhD, (co-inventor), who have been working together on various respiratory care initiatives since the 1980s. Other collaborators on the project include: Robert M. DiBlasi, RRT-NPS, FAARC (co-inventor); Kathleen D. Bongiovanni, MIPH, MS; Christopher R. Howard, MBA; Jack Hildebrandt, PhD; and John Walton.

Sea-PAP can also work in conjunction with the Hansen Ventilator, a separate respiratory device prototype the Children's team is developing, named after Dr. Hansen. If used together, even more premature infants with respiratory distress could be saved.

"Sea-PAP by itself is the quickest and cheapest way we can save thousands of infants with respiratory distress," said Dr. Hansen. "If used in conjunction with the Hansen Ventilator, that number could increase substantially. We hope to have the combined offering in market later in this decade."

The Hansen Ventilator is being developed by the same team working on Sea-PAP.


'/>"/>

Contact: Kathy Porada
kathy.porada@seattlechildrens.org
206-987-7856
Seattle Children's
Source:Eurekalert

Related medicine news :

1. Registered Nurses from Public Health - Seattle & King County Hold Informational Picket to Highlight Public Safety Concerns
2. Seattle Suttons Healthy Eating Sponsoring The Biggest Loser Chicago Casting Call
3. Nalanda West Seattle and Jewel Heart Present Gelek Rimpoche: Fearless Compassion and Principles for a Happy Life
4. Seattle BioMed Offers the Gift of Hope for Mother's Day
5. Cartoon Network's MOVE IT MOVEMENT TOUR Stops in Seattle Market
6. QuickMedical Open House and Benefit for Seattle Children's Hospital A Resounding Success
7. University, government and philanthropic leaders converge in Seattle to advance global health
8. National thought leaders in mental health and health-care delivery gather for Seattle summit
9. Parents Want Electronic Access to Their Childrens Docs: Survey
10. Researcher at Childrens Hospital LA discovers way to overcome radiation resistance in leukemia
11. ReportsandReports : The Gastrointestinal Market Outlook to 2014: Market Dynamics, Competitive Landscape, Emerging Therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 2017 , ... Z-Medica, LLC, a leading developer and marketer ... will acquire QuikClot® Bleeding Control Kits® (BCK) to equip up to 1,000 schools ... by the American College of Surgeons, U.S. Department of Defense, Department of Homeland ...
(Date:3/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce that ... Mr. Still was selected through a careful months-long search by the RBMA Board of ... our members, has been a part of building the RBMA since 1992,” said RBMA ...
(Date:3/28/2017)... Conn. (PRWEB) , ... March 28, 2017 , ... ... based in Wethersfield, Conn., has relocated its corporate headquarters to a new, more ... clients. , In October 2016, Qualidigm purchased a distressed office building in ...
(Date:3/28/2017)... ... March 28, 2017 , ... METTLER TOLEDO Process ... in power plant water and steam. , Chlorides and sulfates cause pitting and ... to extensive maintenance and unplanned shutdowns. Monitoring these ions at low ppb levels ...
(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin ... one of few medical professionals in the country to sit on the 2017 National ... Aesthetics, in just 2 years Dr. Harper helped propel the clinic from a small ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... DIEGO and VANCOUVER, British Columbia, March 27, 2017 ... ) (the "Company" or "Sophiris"), a clinical late-stage ... of patients with urological diseases, today reported fourth ... key corporate highlights. Key Corporate ... Clinical Development for Localized Prostate Cancer. During 2016, ...
(Date:3/27/2017)... , March 27, 2017 BioLineRx ... and immunology, announced today that AGI-134, an immunotherapy for the ... of Agalimmune Ltd., will be featured at the upcoming ... Washington, DC to be held on ... ...
(Date:3/27/2017)... -- The staggering cost of cancer treatment means only ... the latest treatment options against cancer. Even among the ... inadequate or no health insurance and are oftentimes saddled ... modern cancer treatment is almost non-existent for cancer patients ... mission statements of pharmaceutical and biotech companies often quote ...
Breaking Medicine Technology: