Navigation Links
Search for biomarkers aimed at improving treatment of painful bladder condition
Date:8/11/2014

Winston-Salem, N.C. August 11, 2014 Taking advantage of technology that can analyze tissue samples and measure the activity of thousands of genes at once, scientists at Wake Forest Baptist Medical Center are on a mission to better understand and treat interstitial cystitis (IC), a painful and difficult-to-diagnose bladder condition.

"We are looking for molecular biomarkers for IC, which basically means we are comparing bladder biopsy tissue from patients with suspected interstitial cystitis to patients without the disease. The goal is to identify factors that will lead to a more definitive diagnosis, and then use this information to tailor treatments to the patient," said senior author Stephen J. Walker, Ph.D., associate professor at Wake Forest Baptist's Institute for Regenerative Medicine.

The team's initial work, published online ahead of print in the Journal of Urology, found that tissue from IC patients with low bladder capacity had a significantly different gene expression profile than both IC patients with normal bladder capacity and study participants without IC. The findings suggest there may be a sub-type of IC.

"This is the first study to document functional genomic variation based solely on bladder capacity," said Robert J. Evans, M.D., a co-author and IC specialist in Wake Forest Baptist Urology. "Interstitial cystitis is notoriously difficult to diagnose. In fact, one report found that it takes the average patient eight years and seeing five doctors to be correctly diagnosed. The identification of biomarkers to improve diagnosis or treatment would be a significant breakthrough for patients and physicians."

IC, also known as bladder pain syndrome, is a condition in which the bladder lining is tender and easily irritated. Symptoms can include severe pelvic pain, urinary urgency and frequency and painful sexual intercourse. IC is often misdiagnosed as other conditions such as endometriosis, kidney ston
'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers uncover cancer-causing mechanism behind powerful human oncogene
2. GW researcher receives grant to develop genetic tools to study parasitic infections
3. 13.8% CAGR for Healthcare Workforce Mgmt. Systems Market Globally to 2019 Says a New Research Report Available at ReportsnReports.com
4. Kessler Foundation researchers publish study on task constraint and task switching
5. Penn-led expert panel calls for public health research on natural gas drilling
6. LSUHSC research shows program to combat childhood obesity gets kids in daycare moving
7. A new cause of osteoarthritis identified by research on a rare disease
8. New Research Finds Cholesterol Drugs No Match for Mesothelioma, According to Surviving Mesothelioma
9. Global Medication Management Market To See 14%–16% CAGR to 2019 Says a New Research Report Available at ReportsnReports.com
10. Label-Free Binding Industry (LF Binding) Trends & 2014 Analysis Report Available at RnRMarketResearch.com
11. Sport and Spine Rehab’s Clinical Research Foundation Team Attends the 16th Annual Performance Health Scientific Advisory Committee (TRAC) Meeting in Park City Utah
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... ... “ Frequentz ” was featured on NewsWatch as part of its monthly AppWatch, ... iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology expert, conducted ... product movement from beginning to end. , Businesses benefit greatly from having the ability ...
(Date:8/28/2015)... ... August 28, 2015 , ... Drugs ... Dr. James Strawbridge, gives a new approach on solutions in his new book ... the employer and employees getting together for meaningful group meetings. "This would educate ...
(Date:8/28/2015)... ... 2015 , ... The Nashville Business Journal recently announced its ... Mr. Troy Mizell, Chairman of the Board at MyGenetx, is one of ... Awards will recognize Nashville military veterans who, through their professional and personal efforts, ...
(Date:8/28/2015)... ... August 28, 2015 , ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is ... in shoulder pain, hip pain, neck pain, stiffness, muscle spasms, and numbness. ... University of Illinois, and then went on to earn his title of Doctor of ...
(Date:8/28/2015)... ... 28, 2015 , ... The Quatela Center for Plastic Surgery is excited to ... nonsurgical product approved by the Food and Drug Administration to eliminate submental fat, also ... William Koenig are among the premier cosmetic surgeons in Rochester to offer this ...
Breaking Medicine News(10 mins):Health News:Track Product Movement from Beginning to End with Frequentz 2Health News:MyGenetx Board Member Receives Veterans Award 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 2Health News:Non-surgical Treatment to Get Rid of The "Double Chin," Kybella™, Now Available at the Quatela Center for Plastic Surgery 3
... that the absence of a certain protein interferes with ... the New England journal of medicine,it provides insight ... The protein aquaporin-1has a definitive role in the normal ... study.The study showed that individuals who have a deficiency ...
... usage of antidepressants rather going to psychotherapy among most foreigners. ... depression changed from 1985 to 1999. // ,The rate ... persons to 2.5 per 100 over this time.The proportion of ... cent to 70 per cent - probably due to the ...
... The third man to receive an experimental artificial heart ... the device.// Bobby Harrison appeared at a news conference ... Heart Institute, where he underwent surgery on September 26, ... battery-powered plastic-and-titanium device that's completely implanted into the patient. ...
... 20 years, scientists have laboured under the assumption that ... form its structure and carry out its activities. However, ... influenza virus protein.This protein may kill immune system cells ... potency, the researchers say.// ,The scientists turned up ...
... Too much vitamin A may increase the risk of hip ... things as healthy skin and hair and bone growth.// Researchers ... from food and vitamin supplements - had double the risk ... ,One theory is that too much vitamin A ...
... Stiff person syndrome (SPS) causes the muscles in the limbs ... highly effective treatment for a disorder of the nervous system ... the condition are often too disabled to walk or move, ... suffer a spasm and fall. The condition resembles chronic tetanus. ...
Cached Medicine News:
(Date:8/27/2015)... Aug. 27, 2015  The Academy of Managed ... Drug Administration,s (FDA,s) draft guidance and proposed rule ... biosimilars, to bear a nonproprietary name with an ... seeking a decision from the FDA on the ... care stakeholders urging the agency to use the ...
(Date:8/27/2015)... Aug. 27, 2015 DURECT Corporation (Nasdaq: ... present at three upcoming healthcare conferences.  ... will present at the Rodman & Renshaw Investment Conference ... The conference is being held at the St. Regis ... A live audio webcast of the presentation will be ...
(Date:8/27/2015)... ieCrowd™ today announced the achievement of ... the company,s supplemental oxygen delivery device, Smart Oxygen ... by ieCrowd,s subsidiary Smart Oxygen Solutions TM , ... oxygen based on level of activity.  The FDA ... Smart Oxygen device would require a series of ...
Breaking Medicine Technology:AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2DURECT to Participate in Upcoming Healthcare Conferences 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4
... Dr. Marisa Weiss, president and founder of Breastcancer.org and ... letter to the U.S. Food and Drug Administration prior ... review data for Avastin,s use in metastatic HER2-negative breast ... has recommended removing Avastin,s approval to treat breast cancer, ...
... reimbursement rates for home medical equipment and services (HME) ... as a result of Medicare,s bidding program going into ... largest metropolitan areas in the U.S. ... City, Miami, Orlando, Pittsburgh, and Riverside, California. The bidding ...
Cached Medicine Technology:Non-Profit Breastcancer.org Shares Concerns with FDA on Avastin Breast Cancer Recommendation 2Non-Profit Breastcancer.org Shares Concerns with FDA on Avastin Breast Cancer Recommendation 3Problems Emerge in Competitive Bidding Pricing Scheme for Home Medical Equipment; Economists Predict the Program Will Fail 2Problems Emerge in Competitive Bidding Pricing Scheme for Home Medical Equipment; Economists Predict the Program Will Fail 3