Navigation Links
Sealing off portion of intestinal lining treats obesity, resolves diabetes in animal model
Date:11/24/2008

digestion and glucose metabolism.

The device used in the current study a 10-cm-long impermeable sleeve secured at the outlet of the stomach and lining the duodenum and upper jejunum of rats prevents the sensing and absorption of nutrients in that area and also delivers relatively undigested nutrients to the lower jejunum. The researchers implanted the device, called an endoluminal sleeve, in eight rats that had been brought up on a high-fat diet, resulting in obesity and mild diabetes. Another eight rats underwent a similar procedure without implantation of the endoluminal sleeve. After a one-week recovery period, both groups were given access to the same high-fat diet.

During subsequent weeks, animals receiving the device took in almost 30 percent fewer calories than did those receiving the sham procedure. The treated rats weighed 20 percent less than the control group by the seventh week after the procedure and maintained that weight loss during the 16-week study period. Their fasting blood glucose levels, insulin levels and oral glucose tolerance all returned to normal levels.

To test whether the endoluminal sleeve could prevent obesity, the investigators implanted the device in rats genetically prone to rapid weight gain but lean since they had been brought up on a low-fat diet. The treated rats and a control group that had the sham procedure were then given access to a high-fat diet. While both groups gained weight during the postsurgical period, most of the rats receiving the endoluminal sleeve ate less than the control rats and weighed 12 percent less four weeks after the procedure. Examination of the treated animals that gained as much as the controls revealed that the sleeves had become detached and were eventually excreted.

"A key finding of this study is that the device induced a decrease in food intake as part of its effect and does not act by reducing absorption of nutrients," Kaplan says. "Like gast
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. portionpals(R) Sales Reach a Whopping 250,000 Units in 3 Months!
2. Tips for Keeping Food Portions Under Control, from Harvard Womens Health Watch
3. COLORBLENDS to Donate Portion of Sales of Spring Forward Daffodil Blend to the Christopher and Dana Reeve Foundation
4. Looming Medicare cuts will disproportionately hurt physicians in small practices
5. Medicare Cuts Pose Disproportionate Threat to Idahos Rural Seniors, Local Jobs Base
6. Childhood sleep-disordered breathing disproportionately affects obese and African-Americans
7. Royalty Pharma Acquires a Portion of Northwestern Universitys Royalty Interest in Lyrica(R) for $700 Million
8. Intel Co-Founder Andrew S. Grove Dedicates Portion of His Estate, Up to $40 Million, to Michael J. Fox Foundation
9. In jazz improv, large portion of brains prefrontal region takes 5 to let creativity flow
10. Lose Weight This Spring With Portion Control Diet Tool
11. Bioniche Converts a Portion of its Debt to Equity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... California (PRWEB) December 21, 2014 ... have announced a new intro plugin for Final Cut ... animate pictures, videos, logos, and more with absolute ease.” ... given our users the tools needed to easily animate ... allows Final Cut Pro X users to animate pictures, ...
(Date:12/21/2014)... Concept Plus, LLC. a SDB and ... Fairfax, VA., today announced it has been recognized by ... which ranks the fastest growing government contracting small businesses by ... , This is the first year that Concept Plus, LLC., ... with a 95.92% compound annual growth rate. “For Concept Plus ...
(Date:12/20/2014)... Weddingshe.com has recently announced its new collection ... of special occasion dresses for the coming new year. ... occasion dresses for global women. Now, all the models ... to 80% off. Among the new items, the model ... Dress) is very popular. What’s more, Weddingshe.com also provides ...
(Date:12/20/2014)... The print component of Healthy Aging is distributed ... 160,000 copies and an estimated readership of 420,000. The ... media strategy and across a network of top news ... of the campaign, click here . , The ... of CTV’s The Social. Lainey Lui, Melissa Grelo, ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 Angeldress.co.uk, the ... something great for worldwide dress fans. The company has ... news and information. For the holiday season, Angeldress ... about special wedding apparel. , Angeldress.co.uk prides itself in ... unsurpassed level of service. All the company’s outfits are ...
Breaking Medicine News(10 mins):Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:Concept Plus, LLC. Named One of Washington Technology’s Fast 50 2Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2
... Address Will Show How Pharmaceutical Marketers Can Leverage ... Calif., March 10 Spigit, the leader in ... announced today that company co-founder and CTO Padmanabh ... Center for Business Intelligence,s 8th Annual Forum ...
... The Institute for Patient Blood Management and Bloodless ... Bloodless Medicine and Surgery) at Englewood Hospital and ... The new name reflects the Institute,s commitment to ... products to improve patient outcomes.Since the 1994 inception ...
... physician researchers from Hasbro Children,s Hospital and Children,s Hospital Boston ... known as deformational plagiocephaly (DP), or more commonly as flat ... edition of the Journal of Craniofacial Surgery . ... Pediatrics, many parents have been placing babies on their backs ...
... ALEXANDRIA, Va., March 10 The Assisted Living ... legislation that will provide relief to one million ... prescription drugs under Medicare.The bill ends discrimination against ... Medicaid but live in home and community based ...
... guide healthcare systems in providing care that is free ... is releasing its 2009 Safe Practices for Better Healthcare. ... Practices nationwide, a year-long webinar series will begin in ... from experts in the field."The Safe Practices offer clear ...
... of AHIP,s new survey of small group coverageWASHINGTON, ... businesses must be a top priority as the ... of Independent Business (NFIB) and America,s Health Insurance ... conference."We must work together to pursue creative, private ...
Cached Medicine News:Health News:Spigit Enterprise Community Expert to Highlight Enterprise 2.0 Apps for Pharma Companies at Annual CBI eMarketing Forum 2Health News:Spigit Enterprise Community Expert to Highlight Enterprise 2.0 Apps for Pharma Companies at Annual CBI eMarketing Forum 3Health News:Englewood Hospital Marks 15 Years of Leadership in Improving Patient Outcomes Through Bloodless Medicine and Surgery 2Health News:Englewood Hospital Marks 15 Years of Leadership in Improving Patient Outcomes Through Bloodless Medicine and Surgery 3Health News:New study identifies risk factors in severity of 'flat head syndrome' in babies 2Health News:New study identifies risk factors in severity of 'flat head syndrome' in babies 3Health News:ALFA Calls for Co-Pay Equity for Home and Community Based Seniors 2Health News:'Patient Safety Can't Wait' - NQF Calls for Faster Spread of Safe Practices 2Health News:'Patient Safety Can't Wait' - NQF Calls for Faster Spread of Safe Practices 3Health News:'Patient Safety Can't Wait' - NQF Calls for Faster Spread of Safe Practices 4Health News:NFIB and AHIP Urge Focus on Affordable Health Care for Small Businesses 2Health News:NFIB and AHIP Urge Focus on Affordable Health Care for Small Businesses 3Health News:NFIB and AHIP Urge Focus on Affordable Health Care for Small Businesses 4
(Date:12/19/2014)... separating membrane market has witnessed robust development with the ... as a later starter. In 2012, the size of ... billion, with the proportion worldwide soaring to 16.3%. It is ... will continue its growth rate by around 20% in the ... to roughly RMB25 billion. An integrated membrane industrial ...
(Date:12/17/2014)... HOLBROOK, N.Y. , Dec. 17, 2014 /PRNewswire/ ... that The Depository Trust Company (DTC) has made ... the Deposit Chill on the Company,s stock effective ... of Northstar,s common stock for depository and book ... and the Company is now once again fully ...
(Date:12/17/2014)... -- IGI Laboratories, Inc. (NYSE MKT: IG; "IGI" or the ... $125 million aggregate principal amount of 3.75% Convertible Senior ... and sold only to qualified institutional buyers pursuant to ... amended (the "Securities Act"). The Notes bear ... payable semiannually in arrears on June 15 and December ...
Breaking Medicine Technology:Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4
... Sciences University, Augusta, GA  exhibited a poster ... Research in Los Angeles, in which their clinical study ... IV Connector significantly decreased the incidence of catheter-related ... to a simple split septum with negative displacement IV ...
... Food and Drug Administration is warning that terbutaline administered by ... in pregnant women for prevention or prolonged (beyond 48-72 hours) ... maternal heart problems and death. In addition, oral terbutaline tablets ... labor. The FDA is requiring the addition of a Boxed ...
Cached Medicine Technology:New Clinical Study Shows RyMed InVision-Plus® IV Connector Dramatically Reduced Catheter-Related Bloodstream Infections by Over 92% 2New Clinical Study Shows RyMed InVision-Plus® IV Connector Dramatically Reduced Catheter-Related Bloodstream Infections by Over 92% 3FDA Warns Against Certain Uses of Asthma Drug Terbutaline for Preterm Labor 2FDA Warns Against Certain Uses of Asthma Drug Terbutaline for Preterm Labor 3
Sterile Silicone Oil for Intraocular Application....
Round knurled handle, overall length 130 mm....
Optimum C/D/S Solution is a sterile cleaning, disinfecting, and storage solution for use with fluorosilicone acrylate and silicone acrylate rigid gas permeable (RGP) and hard contact lenses....
Hosford foreign body spud 4 3/4 inches, gouge blade 1 x 7 mm rounded tip, angled to left....
Medicine Products: