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Sealing off portion of intestinal lining treats obesity, resolves diabetes in animal model
Date:11/24/2008

digestion and glucose metabolism.

The device used in the current study a 10-cm-long impermeable sleeve secured at the outlet of the stomach and lining the duodenum and upper jejunum of rats prevents the sensing and absorption of nutrients in that area and also delivers relatively undigested nutrients to the lower jejunum. The researchers implanted the device, called an endoluminal sleeve, in eight rats that had been brought up on a high-fat diet, resulting in obesity and mild diabetes. Another eight rats underwent a similar procedure without implantation of the endoluminal sleeve. After a one-week recovery period, both groups were given access to the same high-fat diet.

During subsequent weeks, animals receiving the device took in almost 30 percent fewer calories than did those receiving the sham procedure. The treated rats weighed 20 percent less than the control group by the seventh week after the procedure and maintained that weight loss during the 16-week study period. Their fasting blood glucose levels, insulin levels and oral glucose tolerance all returned to normal levels.

To test whether the endoluminal sleeve could prevent obesity, the investigators implanted the device in rats genetically prone to rapid weight gain but lean since they had been brought up on a low-fat diet. The treated rats and a control group that had the sham procedure were then given access to a high-fat diet. While both groups gained weight during the postsurgical period, most of the rats receiving the endoluminal sleeve ate less than the control rats and weighed 12 percent less four weeks after the procedure. Examination of the treated animals that gained as much as the controls revealed that the sleeves had become detached and were eventually excreted.

"A key finding of this study is that the device induced a decrease in food intake as part of its effect and does not act by reducing absorption of nutrients," Kaplan says. "Like gast
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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

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