Navigation Links
Sea Squirt Helps Researchers Test New Alzheimer's Drug
Date:3/2/2010

Using tadpoles may speed up process for experimental studies

TUESDAY, March 2 (HealthDay News) -- The humble sea squirt may offer a new way to test drugs to treat Alzheimer's disease, U.S. researchers say.

Sea squirts are marine organisms that have a hard outer tunic with a soft body inside. Adult sea squirts spend their lives attached to one spot on underwater structures such as the pilings of piers. They're simple creatures, but sea squirts share about 80 percent of their genes with humans, including the genes to develop the types of plaques that accumulate in the brains of Alzheimer's patients.

This led San Diego State University scientists to try to study Alzheimer's disease in sea squirts. They took a mutant protein found in human families with hereditary Alzheimer's disease and put it in immature, sea squirt tadpoles. This resulted in aggressive development of plaques in the tadpoles' brains in just one day, along with accompanying behavioral defects. However, these effects were reversed when the tadpoles were given an experimental drug designed to prevent plaque formation.

This is the first invertebrate creature found to be able to process the plaque-forming protein. Vertebrates take months or years to develop plaques after receiving the protein.

The findings suggest that sea squirts may offer an excellent model for testing new Alzheimer's drugs, the researcher said.

The study will be published in an upcoming issue of the journal Disease Models and Mechanisms.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.



-- Robert Preidt



SOURCE: The Company of Biologists, news release, March 2, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
2. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
3. Radiation and drug combo helps boost efficacy of lung cancer treatment
4. Childs Flu Shot Helps Whole Family
5. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
6. Generic prostate drug helps find high-risk cancers early
7. Tamoxifen Helps Treat Bipolar Disorder
8. Imaging Software Helps Track, Treat Injured Brains
9. GPS-like technology helps pinpoint best methods for moving injured players
10. New Website Helps Women Be Fit, Sexy and in Control!
11. Brain Defect Helps Drive Fragile X Syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Halo Labs announces the European launch of their ... HORIZON at MIBio 2017 in Cambridge, U.K ... matter in biopharmaceutical samples with unprecedented speed and sensitivity while using ... Backgrounded Membrane Imaging. ... subvisible particle analysis system ...
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
Breaking Medicine Technology: