Navigation Links
Scripps research team unravels new cellular repair mechanism
Date:8/6/2008

ss during the S phase, the entire process stalls.

"If either the replicating enzymes run into damage, or if there are insufficient precursors for making DNA, then this checkpoint response will be activated," says Wittenberg. "There are two aspects to this response. One is to prevent the cycle from proceeding, and the other is to prepare the cell to deal with the damage."

Wittenberg and his colleagues have found that during normal cell division, Nrm1's binding to DNA represses the activity of genes expressed during the G1 phase, in preparation for the subsequent S phase. The team has now shown that when such stalls occur, collectively referred to as DNA stress, Nrm1's repression of the G1 genes is blocked, allowing those genes to be turned back on. This presumably enables production of proteins needed to correct the problem that caused the stall.

"So, now you have cells in the S phase, which don't typically express these genes, expressing them," says Wittenberg.

The researchers were able to tease out Nrm1's specific activities through experiments where they intentionally blocked the cell cycle in yeast cells by robbing them of the precursors needed for DNA replication. They were able to show that, as a result of this induced stress, Nrm1 was chemically altered by a known checkpoint enzyme, resulting in the loss of binding to G1 genes. This resulted in expression of the G1 genes during S phase. Because those genes encode replication and repair enzymes, re-expression of the G1 genes facilitates re-starting of DNA replication.

Because the onset of cancer is so intimately tied to problems in the cell cycle, numerous cancer drugs currently under development target checkpoint mechanisms, with the goals of making cells more sensitive to chemotherapeutic agents that damage DNA, and in some cases protecting normal proliferating cells from cell cycle arrest and death. Given that, once Nrm1's human analog and its activity are id
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists find seizure drug reverses cellular effects
2. Scripps Memorial Hospital Nurses Throw Out CNA
3. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
4. Scripps research team wins $4M grant to study effects of chronic marijuana use
5. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
6. Scripps research scientists devise approach that stops HIV at earliest stage of infection
7. Scripps scientists peg wind as the force behind fish booms and busts
8. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
9. Scripps research scientists find new genetic mutation that halts the development of lupus
10. Scripps research scientists discover chemical triggers for aggression in mice
11. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... 26 As the voice of the global ... Organizations (ACRO) had the honor of presenting before ... 26th, 2009 in Tokyo. ACRO Chair Derek Winstanly, ... and ACRO Executive Director Douglas Peddicord, Ph.D. addressed ...
... (PHILADELPHIA) Researchers from Thomas Jefferson University have identified ... in the growth and migration of prostate cancer cells, ... in the American Journal of Pathology . , ... of the protein when compared to normal prostate cells, ...
... Feb. 26 On Monday, March 2, the ... to become "The Healthiest Company in Green Bay." The firm ... them at that goal.The 30-person agency is collaborating with Health ... ( www.hatwork.com ). The title of "Healthiest Company in Green ...
... Physicians Offers Secure Message Capability to Facilitate ... Human Science, Inc. (HSI), a Rockville ... launch of an innovative software service that ... care in a secure environment. PatientCarenet.Org ...
... monitoring, and biostatistics for several early-stage clinical trials and registries ... ... Clinipace , a growing clinical research solutions company, today announced that ... aggregate, more than $2.8 million., , ,With a focus on emerging ...
... Feb. 26 Orthopaedic surgeon Michael L. Parks, MD, ... American Academy of Orthopaedic Surgeons (AAOS) ( ... Vegas. He will serve the Academy as Member-at-Large ... specializes in the reconstruction of arthritic conditions affecting the ...
Cached Medicine News:Health News:ACRO Presents at Japan CRO Association Commemorative Symposium 2Health News:Proepithelin encourages cell growth and migration in prostate cancer 2Health News:Arketype to Become Green Bay's Healthiest Company in One Year -- Wanna Bet? 2Health News:Arketype to Become Green Bay's Healthiest Company in One Year -- Wanna Bet? 3Health News:Human Science, Inc. Launches PatientCarenet.Org 2Health News:Human Science, Inc. Launches PatientCarenet.Org 3Health News:Clinipace Recently Awarded $2.8 Million to Manage Three New Clinical Projects 2Health News:Michael L. Parks, MD, Elected to the American Academy of Orthopaedic Surgeons Board of Directors 2
(Date:12/15/2014)... , Dec. 15, 2014 As medical device ... Product Labeling) markup language standard, content teams have a ... skills to work with the standard. Starting January 2015, ... three webinars on the benefits and the critical aspects ... will be facilitated by Howard Shatz , DCL,s ...
(Date:12/15/2014)... MINNEAPOLIS , Dec. 15, 2014   ... ), one of the nation,s largest and most ... of its business units, DaVita Clinical Research ... capabilities to further expand its extensive clinical research ... chronic kidney disease (CKD) and end-stage renal disease ...
(Date:12/15/2014)... LONDON and BOSTON , ... the leading GPCR structure-guided drug discovery and development company, ... patents in the United States ... of these patents in the US significantly strengthens the ... the major pharmaceutical markets. The suite of ...
Breaking Medicine Technology:Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2
... proud to announce its conference keynote speakers include: Centers ... CBS Evening News Anchor Katie Couric; U.S. ... U.S. Secretary of Commerce Gary Locke. Each will address ... leaders in Washington, D.C. October 18-20 during AdvaMed ...
... Arlington Medical Resources (AMR), a provider of premier ... finds that more than half of all European inpatients ... Sanofi-Aventis,s Clexane (marketed as Lovenox in the U.S. and ... The European Hospital Anticoagulant Market Guide is a ...
Cached Medicine Technology:AdvaMed 2010 Keynote Speakers Announced 2AdvaMed 2010 Keynote Speakers Announced 3European Hospital Anticoagulant Market Dominated by Sanofi-Aventis's Clexane 2
... Pulse Oximeters are high performance, easy-to-use ... proven signal processing to track even ... with Oxismart Advanced Signal Processing and ... identify electronic and optical noise, as ...
The Model 5340 is intended for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
The Model 340DT is a new desk top pulse oximeter that was designed for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
... The Model 130 has expanded memory capabilities ... has memory to retain oxygen saturation and pulse ... modes to best suit your needs:, ,1. ... minutes of information for a single patient, making ...
Medicine Products: