Navigation Links
Scripps research team unravels new cellular repair mechanism
Date:8/6/2008

The research was published today in an advanced, online issue of the Proceedings of the National Academy of Sciences.

The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. Via mechanisms still poorly understood, a checkpoint in the reproduction process can detect problems that interfere with DNA copying. This detection can in turn trigger several potential responses.

"If the cycle is paused because the cell is having some problem," says study lead Professor Curt Wittenberg, of the Scripps Research Departments of Molecular Biology and Cell Biology, "it can't stop and go back, so it either kills the new cell or repairs the problem."

The checkpoint mechanisms that control the cell cycle are of great interest not only because they are such a fundamental aspect of biology, but also because problems in the cycle and its DNA repair mechanisms can lead to mutations that cause the unchecked proliferation of cells associated with various cancers.

The Wittenberg group recently identified a protein dubbed Nrm1 that appeared to play important roles in a yeast cell's successful transition from the G1 phase, in which cells prepare to replicate DNA, to actual replication during the S phase. Now, in the new paper, the Wittenberg group in collaboration with colleagues in the Scripps Research laboratories of Professors Paul Russell and John Yates show what some of those roles are.

At specific points in the cell cycle, groups of genes are turned on and off to produce the enzymes and other components needed for progression into the next cell cycle phase, and a healthy cell will only move forward into the next phase of the cycle if certain standards are met.

However, if a problem arises in the DNA replication proce
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists find seizure drug reverses cellular effects
2. Scripps Memorial Hospital Nurses Throw Out CNA
3. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
4. Scripps research team wins $4M grant to study effects of chronic marijuana use
5. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
6. Scripps research scientists devise approach that stops HIV at earliest stage of infection
7. Scripps scientists peg wind as the force behind fish booms and busts
8. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
9. Scripps research scientists find new genetic mutation that halts the development of lupus
10. Scripps research scientists discover chemical triggers for aggression in mice
11. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... ... the top 5 millionaire dating sites . According to the listings, ... second best in this category. , A spokesperson of Top5MillionaireDatingSites.com said, ...
(Date:8/28/2015)... ... August 28, 2015 , ... External Counterpulsation, also known ... Clinic is now selling External Counterpulsation (EECP or ECP) machines with a full clinic ... has been in business since 2007 helping people prevent and reverse heart disease ...
(Date:8/28/2015)... MO (PRWEB) , ... August 28, 2015 , ... ... testosterone lawsuits now consolidated as MDL 2545, Testosterone Replacement Therapy Products ... a cap on the number of custodial files the PSC may receive for ...
(Date:8/28/2015)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in ... be taken in order to ease the stress on the atmosphere, and lessen the ... understand fully the real cause of global warming and urges them to look into ...
(Date:8/28/2015)... ... , ... A complimentary webinar offered by healthcare consulting and accounting firm PYA ... to mandate bundled payments through the Comprehensive Care for Joint Replacement Program ... for Joint Replacement,” takes place at 12 noon EDT on Wednesday, September 2, 2015. ...
Breaking Medicine News(10 mins):Health News:Top5MillionaireDatingSites.com Publishes Its First List of Reviews of the Best Millionaire Dating Sites 2Health News:Buy New External Counterpulsation (EECP or ECP) With Heart Fit Clinic 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 2Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 3Health News:National Testosterone Lawyers Provide Testosterone Lawsuit MDL Update 4Health News:Wake Up and Smell the Sick Atmosphere Says Yisrayl Hawkins in New Article This Week 2Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3
... NIDCR have created an animal model that mimics ... and dentin dysplasia. Dr. Ashok Kulkarni and his ... of TGF-b1 (transforming growth factor beta-1) in their ... defects, but at two weeks their teeth became ...
... is no longer an exclusively Western problem. Researchers ... threat to people in developing nations, particularly children. ... the biggest threats to the health of poor ... urbanisation, technology, food processing and even leisure time ...
... Board of Examinations has decided to conduct tests for any ... in the country, to ensure a higher standards amongst doctors, ... next month official sources said today. , ... the Indian Gazzette yesterday, specify that students who want to ...
... are more likely to develop heart failure A connection between depression ... researchers at Emory University School of Medicine in the US have ... from heart failure. ,The study included 2000 participants - ... over five per cent of the men and nine per cent ...
... a dash and sprinkel away: Researchers with the U.S. ... to making food tastier, are an abundant source of ... a balanced diet.Herbs have higher antioxidant activity than frutis, ... Their findings appear in the Journal of Agricultural and ...
... with arginine and vitamins increased the exercise capacity and quality ... acid// that can produce the gas nitric oxide which, in ... might think that arginine might help people with heart problems, ... heart. ,In fact the validation for arginine supplements ...
Cached Medicine News:Health News:Heriditary dental disorders 2Health News:Herbs: rich soure of antioxidants 2
(Date:8/28/2015)... Massachusetts y LONDRES, 28 de agosto ... AEX: PHIA) anunció hoy su participación en el  ... exhibirá sus soluciones cardiológicas más recientes y novedosas, ... Cardiovascular, que conectan a las personas y la ... de ayudar a diagnosticar, guiar los tratamientos y ...
(Date:8/28/2015)... LONDON , August 28, 2015 ... approach seamlessly connects people, technologies and care protoc ... improving outcomes and the cost of healthcare delivery   ... PHIA) today announced its presence at  ESC Congress 2015 , where ... Model A.I. , EchoNavigator and IntelliSpace Cardiovascular, that connect people ...
(Date:8/28/2015)... 28, 2015 The global ... 49.12 billion by 2020, growing at a CAGR of ... report by Grand View Research, Inc. Monitoring services is ... from 2014 to 2020.      (Logo: ... with rising incidences of chronic diseases such as cancer, ...
Breaking Medicine Technology:Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 2Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 3Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5
... China, Oct. 30 /PRNewswire-Asia/ -- China Medicine ... "the Company"), a developer,and leading distributor of ... nutritional and dietary supplements,and medical devices and ... subsidiary in China, Konzern Pharmaceuticals, it has ...
... TAIPEI, Taiwan, Oct. 30 /PRNewswire-Asia/ -- ... from bench to bedside and community, Microlife is ... solution entails a series of,innovative professional blood pressure ... treatment follow-up. Microlife successfully,developed several physician-guided blood ...
Cached Medicine Technology:China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 2China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 3China Medicine Corporation to Acquire Pharmaceutical Manufacturer in Guangzhou 4Microlife-WatchBP Series is Proud to Present its Total Concept at the World Hypertension Congress 2Microlife-WatchBP Series is Proud to Present its Total Concept at the World Hypertension Congress 3
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: