Navigation Links
Scripps research team unravels new cellular repair mechanism
Date:8/6/2008

The research was published today in an advanced, online issue of the Proceedings of the National Academy of Sciences.

The cell cycle, which allows cells to replicate their DNA and produce new cells, is controlled by a complex concert of enzymes and other components. In addition there are "checkpoint" mechanisms that can block continuation of the process if something goes amiss. Via mechanisms still poorly understood, a checkpoint in the reproduction process can detect problems that interfere with DNA copying. This detection can in turn trigger several potential responses.

"If the cycle is paused because the cell is having some problem," says study lead Professor Curt Wittenberg, of the Scripps Research Departments of Molecular Biology and Cell Biology, "it can't stop and go back, so it either kills the new cell or repairs the problem."

The checkpoint mechanisms that control the cell cycle are of great interest not only because they are such a fundamental aspect of biology, but also because problems in the cycle and its DNA repair mechanisms can lead to mutations that cause the unchecked proliferation of cells associated with various cancers.

The Wittenberg group recently identified a protein dubbed Nrm1 that appeared to play important roles in a yeast cell's successful transition from the G1 phase, in which cells prepare to replicate DNA, to actual replication during the S phase. Now, in the new paper, the Wittenberg group in collaboration with colleagues in the Scripps Research laboratories of Professors Paul Russell and John Yates show what some of those roles are.

At specific points in the cell cycle, groups of genes are turned on and off to produce the enzymes and other components needed for progression into the next cell cycle phase, and a healthy cell will only move forward into the next phase of the cycle if certain standards are met.

However, if a problem arises in the DNA replication proce
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. Scripps Research scientists find seizure drug reverses cellular effects
2. Scripps Memorial Hospital Nurses Throw Out CNA
3. Scripps Florida scientists develop a process to disrupt hepatitis C virion production
4. Scripps research team wins $4M grant to study effects of chronic marijuana use
5. Scripps Florida awarded $7.6 million grant to develop novel treatment for Parkinsons disease
6. Scripps research scientists devise approach that stops HIV at earliest stage of infection
7. Scripps scientists peg wind as the force behind fish booms and busts
8. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
9. Scripps research scientists find new genetic mutation that halts the development of lupus
10. Scripps research scientists discover chemical triggers for aggression in mice
11. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2013)... Drug Administration (FDA) imposes new graphic warning labels ... Amendment challenge if they depict health consequences and ... says a Georgetown University Medical Center public health ... labelswhich combine images with health warningsare a widely ... countries, but the tobacco industry argues they are ...
(Date:6/17/2013)... 17, 2013 Daimer Industries, Inc.®, a ... equipment , such as expertly designed carpet steam cleaner ... Pro Plus 200S for apartment dwellers and homeowners. The ... in 15 minutes and pressure levels up to 75 ... can be used to clean carpet spots and areas ...
(Date:6/17/2013)... Bust’DD (pronounced ‘busted’), a new company that will provide bras ... busts, will soon launch their crowdfunding campaign on Indiegogo. The ... of ill-fitting bras and want to offer beautiful, quality intimate ... at least $25,000 to create their beta product line with ... scale. , In order to kick off the campaign and ...
(Date:6/17/2013)... June 17, 2013 Today, Zane ... HRAs for small businesses . Zane Benefits, which ... sponsored health benefits, is the leader in ... . , According to Zane Benefits’ website, stand-alone ... or HRAs, offer small businesses an affordable way ...
(Date:6/17/2013)... 2013 Dallas-based physician Dr. Connie Casad ... offer the hybrid concierge model from Concierge Choice Physicians. ... her patients a wider variety of options and to ... emphasis on prevention and wellness had that option. The ... concierge-style of medicine, but doesn't force the physician's longtime ...
Breaking Medicine News(10 mins):Health News:Can new FDA graphic warning labels for tobacco pass a first amendment legal challenge? 2Health News:Daimer Ships Vapor Steam Cleaner For Homeowners 2Health News:Daimer Ships Vapor Steam Cleaner For Homeowners 3Health News:Arizona Startup Bust’DD Looking to Start a BRAvolution 2Health News:Arizona Startup Bust’DD Looking to Start a BRAvolution 3Health News:Zane Benefits Publishes New Information on Stand-Alone HRAs for Small Businesses 2Health News:Dr. Casad Offers Hybrid Concierge Model from Concierge Choice Physicians 2Health News:Dr. Casad Offers Hybrid Concierge Model from Concierge Choice Physicians 3
... African Chamber of Commerce (USACC) has expressed concern recently following Pope ... outrage among health agencies and others who are on the front ... ... DC (Vocus) April 11, 2009 -- The United States African ...
... say, , , FRIDAY, April 10 (HealthDay News) -- U.S. ... raise the risk of schizophrenia in some people, a ... The study involved a genetic analysis of 24 Canadian ... DNA change that increases gene expression was found in ...
... and mercury exposure , , SATURDAY, April 11 (HealthDay News) -- ... for optimal maternal health and fetal growth and development. That ... how much seafood moms-to-be can safely consume without exposing their ... of ongoing debate. , The U.S. Food and Drug ...
... Center is Now Open , ... (PRWEB) April 11, 2009 -- iCRco ... by the US army in August of 2008. Units from the initial ... on a regular basis throughout 2009. To serve the US military optimally ...
... Dr. Rajesh Khanna discusses success of a new procedure, PRELEX. ... ... In the upcoming May issue of Valley Life (West Valley Magazine), ... his practice and his latest procedure PRELEX. PRELEX treats the condition ...
... April 11 Following is the daily "Profile America" ... http://www.newscom.com/cgi-bin/prnh/20090226/CENSUSLOGO ) SATURDAY, APRIL 11: DONATE LIFEProfile ... month of spring and resurgence. It,s also National ... donation to give a new lease on life to ...
Cached Medicine News:Health News:Pope Benedict Calls for Sex Without Condoms in Africa 2Health News:Gene Variant Tied to Schizophrenia 2Health News:How Much Fish to Eat While Pregnant? 2Health News:How Much Fish to Eat While Pregnant? 3Health News:iCRco Adds New Facility to Serve the United States Military 2Health News:Dr. Khanna Featured on Front Cover of Valley Life Magazine 2
(Date:6/17/2013)... Valeant Pharmaceuticals International, Inc. (NYSE: VRX and ... prospectus supplement to its effective shelf registration statement on Form ... regulatory authorities in each of the provinces of ... its common shares to raise gross proceeds of approximately $1.75 ... to the underwriters of the Offering an option, exercisable for ...
(Date:6/17/2013)... June 17, 2013 /PRNewswire-iReach/ -- Weiler Labeling Systems, ... X-4S pressure sensitive labeling head. The X-4S is ... performance requirements that serialization demands. ... uniquely qualified to work with pharmaceutical and medical ... and track and trace implementation strategies. Designed for ...
(Date:6/17/2013)... Franciscan St. Francis Health Cancer Center today (June ... to use a new drug to treat men ... Xofigo ®, a radiopharmaceutical used in patients with late-stage, metastatic ... approved for use by the U.S. Food and Drug Administration. ... may become castration-resistant, which has become resistant to medical or ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Public Offering Of Common Shares 2Valeant Pharmaceuticals Announces Public Offering Of Common Shares 3Valeant Pharmaceuticals Announces Public Offering Of Common Shares 4Weiler Labeling Introduces Serialization-Capable X-4S Labeling Head 2New drug proving effective in attacking advanced prostate cancer 2
... The U.S. Food and Drug Administration has completed ... help speed safe and effective drugs and lower-cost generic ... Margaret A. Hamburg, M.D. said today. The recommendations were ... Secretary Kathleen Sebelius. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ...
... (NYSE: IBM ) scientists have developed a ... can aid researchers and pathologists to investigate critical ... diagnostics. Flickr Photos: http://www.flickr.com/photos/ibm_research_zurich/sets/72157628678347543 ... used in pathology to detect disease markers in ...
Cached Medicine Technology:FDA Completes Work on Three Drug User Fee Programs 2FDA Completes Work on Three Drug User Fee Programs 3FDA Completes Work on Three Drug User Fee Programs 4MADE IN IBM LABS: New Silicon Probe Assists in Disease Diagnostics and Drug Discovery 2MADE IN IBM LABS: New Silicon Probe Assists in Disease Diagnostics and Drug Discovery 3MADE IN IBM LABS: New Silicon Probe Assists in Disease Diagnostics and Drug Discovery 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: