Navigation Links
Scripps research scientists model 3D structures of proteins that control human clock
Date:4/10/2009

In an Early Edition issue of The Proceedings of the National Academy of Sciences (PNAS) on April 9, 2009, the researchers report that they have been able to determine the molecular structure of a plant photolyase protein that is surprisingly similar to two cryptochrome proteins that control the "master clock" in humans and other mammals. They have also been able to test how structural changes affect the function of these proteins.

"The plant photolyase structure provides a much better model to use to study how the cryptochrome proteins in the human clock function than we have ever had before," says the study's lead investigator, Kenichi Hitomi, Ph.D., a postdoctoral research fellow at Scripps Research. "It's like knowing for the first time where the engine is in a car. When you know what the most important parts of the protein are, then you can begin to figure out how it functions."

And when scientists understand that, they can begin to fix the clock when needed, adds senior author Elizabeth Getzoff, Ph.D., professor in the Department of Molecular Biology and member of The Skaggs Institute for Chemical Biology at Scripps Research.

"In addition to decoding how the clock works, a long-term goal is to develop a drug to help people who can't reset their clock when they need to, like people who work night shifts or travel long distances," she says. "Having the three-dimensional protein is a great step forward in both of those pursuits."

To date, it has been impossible to capture a crystal structure of the cryptochrome proteins that control the mammalian circadian clock because they aren't in a sufficiently stable state, Hitomi says. So, working with a team of investigators from both Scripps Research and from other institutions, including two universities in Japan, Hitomi turned to Arabidopsis thaliana, a plant native to Europe and Asia that has one of the smallest genomes of all plants, and so is often used as a
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. Scripps Health Selects Allscripts for Electronic Health Record
2. Scripps research scientists engineer new type of vaccination that provides instant immunity
3. Scripps research scientists develop general-purpose method for detecting trace chemicals
4. Team led by Scripps Scientists increases understanding of two types of blindness
5. KRAUSE, KALFAYAN, BENINK & SLAVENS, LLP, Announces Filing a Class Action Lawsuit Against Scripps Health, et al.
6. Scripps Health Enhances Employee Wellness Program With Home Testing Solutions From BioIQ
7. Scripps Research Institute and IAVI launch worlds first dedicated HIV neutralizing antibody center
8. Scripps Translational Science Institute Contributes to Discovery of Predisposition Gene for Childhood Cancer
9. Scripps research team unravels new cellular repair mechanism
10. Scripps Research scientists find seizure drug reverses cellular effects
11. Scripps Memorial Hospital Nurses Throw Out CNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2009)... of coal for lying about taxes in the healthcare bill ... Baucus has earned a place under the "Naughty" column on ... after being caught telling a brazen lie on the ... healthcare bill would not raise taxes. ,, Speaking on ... " I have also heard ...
(Date:12/15/2009)... Vitech Systems Group, a leading provider of Benefits ... today that it has completed a major V3 ... Guild-Producers Pension & Health Plans (SAG-PH). ,, The ... SAG-PH call center personnel in Burbank, Ventura and ... V3 Benefits Administration System which consolidated data from ...
(Date:12/15/2009)... ,we would have really been in trouble, expert says ... of the pandemic H1N1 swine flu has revealed serious ... health emergencies, a new report says. , The report, ... Robert Wood Johnson Foundation, also finds the dire economy ... "The 2009 H1N1 outbreak is the latest in a ...
(Date:12/15/2009)... ,, WASHINGTON, Dec. 15 Men,s ... healthcare reform does not override the prostate cancer ... 37 states. ,, Prostate cancer screening is particularly ... individuals who are identifiable as high risk, including ... family history of prostate cancer. The American Urological ...
(Date:12/15/2009)... Systems, Inc., a leading provider of advanced inventory ... increase profits by optimizing their inventory and related ... Shoppe has been utilizing the 4R solution since ... solutions have helped us drive significant improvements in ... two years," said Tony Truesdale, President & Chief ...
Breaking Medicine News(10 mins):Health News:ATR: Baucus Earns Place on 2009 "Naughty" List 2Health News:ATR: Baucus Earns Place on 2009 "Naughty" List 3Health News:Screen Actors Guild - Producers Pension & Health Plans Live on New CRM Solution 2Health News:Serious Gaps Revealed in U.S. Response to Health Emergencies 2Health News:Serious Gaps Revealed in U.S. Response to Health Emergencies 3Health News:Men's Health Network Calls on Congress to Complete President Obama's Promise on Health Care Reform 2Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 2Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 3Health News:4R's Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance 4
... BPA might lessen chances of successful pregnancy, research suggests ... a controversial chemical used to harden plastic packaging for ... report. , Bisphenol A (BPA) could hurt the chances ... embryos to attach to the uterus, according to presentations ...
... Watson,Pharmaceuticals, Inc. (NYSE: WPI ), a ... New Drug Application (NDA) for a 6-month,formulation ... hormone (LHRH) agonist, has been accepted for ... (FDA). Watson is seeking marketing approval of,this ...
... Corp (Amex: CHM , CHMU, CHMW) ("CHM") ... Teambest International, Ltd. and,Madame Wang Lahua (collectively, "Seller") ... to terminate the stock purchase agreement among,them pursuant ... of the outstanding,equity of Europe Asia Huadu Environment ...
... far short of government objective of 12%, CDC says , , ... States will meet its Healthy People 2010 objective of reducing ... experts at the U.S. Centers for Disease Control and Prevention. ... health problems, deaths and lost productivity will still plague the ...
... of its 24,965,members and supporters in Georgia, Citizens Against ... the details related to how insurance,broker Kirk Rouse made ... health care plan for county employees. CAGW President Tom,Schatz ... and,asking questions about the process., Schatz wrote, "The ...
... has been approved by the U.S. Food and Drug Administration (FDA) ... regimen to treat moderate to severe postmenopausal dyspareunia (painful sexual intercourse) ... ... COLLEGEVILLE, Pa. (Business Wire EON) November 13, 2008 -- ...
Other Medicine News:Health News:Chemical in Plastics May Cause Fertility Problems 2Health News:Chemical in Plastics May Cause Fertility Problems 3Health News:Watson Announces the NDA for a 6-Month Formulation of TRELSTAR(R) Accepted for Filing by FDA for the Treatment of Advanced Prostate Cancer 2Health News:Watson Announces the NDA for a 6-Month Formulation of TRELSTAR(R) Accepted for Filing by FDA for the Treatment of Advanced Prostate Cancer 3Health News:Watson Announces the NDA for a 6-Month Formulation of TRELSTAR(R) Accepted for Filing by FDA for the Treatment of Advanced Prostate Cancer 4Health News:China Healthcare Acquisition Corp Agrees to Terminate Agreement to Acquire Europe Asia Huadu Environment Holding Pte, Ltd. 2Health News:U.S. Won't Meet 2010 No-Smoking Goals 2Health News:U.S. Won't Meet 2010 No-Smoking Goals 3Health News:CAGW Questions Healthcare Plan Options Presented to the Dougherty County Commission 2Health News: FDA Approves Low-dose Regimen of PREMARIN Vaginal Cream to Treat Moderate to Severe Postmenopausal Dyspareunia – Painful Sexual Intercourse : Agency Grants New Indication for Bothersome Vaginal Symptom Associated with Menopause 2Health News: FDA Approves Low-dose Regimen of PREMARIN Vaginal Cream to Treat Moderate to Severe Postmenopausal Dyspareunia – Painful Sexual Intercourse : Agency Grants New Indication for Bothersome Vaginal Symptom Associated with Menopause 3Health News: FDA Approves Low-dose Regimen of PREMARIN Vaginal Cream to Treat Moderate to Severe Postmenopausal Dyspareunia – Painful Sexual Intercourse : Agency Grants New Indication for Bothersome Vaginal Symptom Associated with Menopause 4
(Date:12/15/2009)... BALTIMORE, Dec. 15 Champions Biotechnology, ... engaged in the development of advanced preclinical platforms ... of oncology drugs, today announced its financial results ... 2009. Full details of Company,s financial results ... www.championsbiotechnology.com . ,, Total revenues for the ...
(Date:12/15/2009)... OrthoWorx, the newly formed industry, community and ... sector in Kosciusko County, is working to connect the ... Chicago and Cleveland via high-speed rail. ,, In a ... Orthopedics Capital of the World -- An overview, ... BioCrossroads, the statewide initiative to grow Indiana,s ...
(Date:12/15/2009)... Tenn., Dec. 15 Medical researchers with ... with their revolutionary new technology for a simple ... ,, Following the success of its pre-clinical ... a patent on the biomarker, CA11-19, and all ... blood test, ColoMarker(TM) will detect colon cancer in ...
Breaking Medicine Technology:Champions Biotechnology Reports Fiscal 2010 Second Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2010 Second Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2010 Second Quarter Financial Results 4Champions Biotechnology Reports Fiscal 2010 Second Quarter Financial Results 5OrthoWorx Urges Warsaw's Inclusion on High-Speed Rail Corridor Connecting Chicago and Cleveland 2OrthoWorx Urges Warsaw's Inclusion on High-Speed Rail Corridor Connecting Chicago and Cleveland 3Researchers Announce Medical Breakthrough with Simple, Inexpensive Blood Test for Colon Cancer 2Laser technology creates new forms of metal and enhances aircraft performance 13107 1Laser technology creates new forms of metal and enhances aircraft performance 13107 2NYU physicists find way to explore microscopic systems through holographic video 13103 1NYU physicists find way to explore microscopic systems through holographic video 13103 2NYU physicists find way to explore microscopic systems through holographic video 13103 3NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 1NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 2NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 3NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 4NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 5NACDS Urges Clarifications Enhancements in Two Pharmacy Reimbursement Provisions in House Healthcare Reform Legislation 52163 6
... IRVING, Texas--(BUSINESS WIRE)--May 15, 2007 - Reata,Pharmaceuticals, Inc. ... May 2007 issue of the journal Cancer Research ... candidate for cancer,was highly effective in a rigorous ... inhibits signaling activity of STAT3, an,important target for ...
... N.C.--(BUSINESS WIRE)--May 17, 2007 - Salix,Pharmaceuticals, Ltd. (NASDAQ:SLXP) ... to the Company's products,will be presented at Digestive ... 2007. Digestive Disease Week is considered the,largest and ... GI,professional. Every year it attracts more than 16,000 ...
Other Medicine Technology:RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds,Significant Promise for Treating Breast Cancer 2RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds,Significant Promise for Treating Breast Cancer 3Salix Pharmaceuticals Previews Digestive Disease Week 2007 2Salix Pharmaceuticals Previews Digestive Disease Week 2007 3Salix Pharmaceuticals Previews Digestive Disease Week 2007 4Salix Pharmaceuticals Previews Digestive Disease Week 2007 5
... a minimally invasive treatment for female stress ... be performed at the same time. This ... sling, the In-Fast Ultra inserter is used ... into the posterior aspect of the pubic ...
... Proven tension-free sling technology marries ... acellular collagen matrix sling, for ... contact between sling and host, ... or vaginal abrasion or erosion ...
... durability of natural tissue with ... ingrowth and natural adaptation to ... all applicable state and federal ... also reduces OR time and ...
... treadmills are designed specifically for rehabilitation facilities. ... absorbing deck that provides the ideal cushioning ... A user-friendly control panel displays all pertinent ... treadmills features a "soft start" the ...
Medicine Products: