Navigation Links
Scripps research scientists illuminate cancer cells' survival strategy
Date:1/26/2012

LA JOLLA, CA -- A team led by scientists at The Scripps Research Institute has discovered key elements of a strategy commonly used by tumor cells to survive when they spread to distant organs. The finding could lead to drugs that could inhibit this metastasis in patients with tumors.

A cell that breaks away from the primary tumor and finds itself in the alien environment of the bloodstream or a new organ, normally is destroyed by a process known as apoptosis. But tumor cells that express high levels of a certain surface protein are protected from apoptosis, greatly enhancing their ability to colonize distant organs. How this protein blocks apoptosis and promotes metastasis has been a mysteryuntil now.

"What we found in this study is that it's not the increased expression of the protein per se that protects a tumor cell, but, rather, the cleavage of this protein by proteolytic enzymes," said Scripps Research Professor James P. Quigley. "This cleavage triggers a signaling cascade in the tumor cell that blocks apoptosis." Quigley is the principal investigator for the study, which was recently published online before print by the journal Oncogene.

"We think that a reasonable strategy for inhibiting metastasis would be to try to prevent the cleavage of this surface protein using antibodies or small-molecule drugs that bind to the cleavage site of the protein," said Elena I. Deryugina, a staff scientist in Quigley's laboratory and corresponding author of the manuscript.

A Protein Linked to Poor Outcomes

The cell-surface protein at the center of this research is known as CUB Domain Containing Protein 1 (CDCP1). In 2003, a postdoctoral fellow in Quigley's laboratory, John D. Hooper, discovered and co-named CDCP1 as a "Subtractive Immunization Metastasis Antigen," also finding that it is highly expressed on the surfaces of metastasis-prone human tumor cells.

Quigley's laboratory and others soon fou
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
2. Top Scientists Explore the Origin of Life in Annual Lasker Lecture at Scripps Research Institute Florida Campus
3. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
4. Scripps Memorial Hospital La Jolla First in San Diego to Achieve Magnet Nursing Re-designation
5. Scripps Announces Plans for Region's First Proton Therapy Center; $185 Million Facility to Offer Advanced Care to Cancer Patients
6. Scripps Research scientists share $2 million in Florida state research grants
7. Scripps Center for Executive Health Now Offers Genetic Testing
8. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
9. NIH awards Scripps Florida scientists $2.3 Million to develop drug addiction treatments
10. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
11. Scripps and Trius team up to develop new antibiotics with US Department of Defense grant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps research scientists illuminate cancer cells' survival strategy
(Date:9/22/2014)... York, New York (PRWEB) September 22, 2014 ... filed against Boston Scientific Corp. continue to move ... in U.S. District Court, Southern District of West ... documents, a new Docket Control Order was issued ... a number of matters pertaining to the upcoming ...
(Date:9/22/2014)... to 40 percent of patients undergoing breast cancer surgery ... all the cancerous tissue in the initial operation. However, ... tested a tool they developed that will help surgeons ... decreasing the chances for repeat operations. ... September 22, 2014 in the Proceedings of the ...
(Date:9/22/2014)... PA (PRWEB) September 22, 2014 An ... for patients to the problem of side-sleeping. "My lower ... side, so I designed a solution to this problem," ... asleep comfortably than to have your arm 'fall asleep.'" ... on his or her side more comfortably. It avoids ...
(Date:9/22/2014)... 2014 The R&D of cancer vaccines ... The statistically important data received from clinical research studies ... The primary challenge to the development of such vaccines ... mechanism of how a human’s immune system works. The ... different individuals owing to known factors with genetics possibly ...
(Date:9/22/2014)... Barbara Bronson Gray HealthDay Reporter ... something every pregnant woman wonders: What can I do to ... taking iron supplements as prescribed may play a role in ... disorder (ASD). The researchers found that mothers of children ... supplements before and during pregnancy than those whose children seem ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, With Issuance of New Order in Federal Boston Scientific Litigation, Bernstein Liebhard LLP Reports 4Health News:The fine line between breast cancer and normal tissues 2Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 2Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 3Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 4Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 2Health News:Could Low Iron Intake During Pregnancy Raise Autism Risk? 3
... bleeding is three times more likely to occur in ... regular basis despite the safety profile of non-steroidal anti-inflammatory ... as early as three days after starting an ibuprofen ... one of the most favorable safety profiles of all ...
... fund ?28m for research in United Kingdom as part ... eradication of Malaria worldwide. Bill Gates along with his ... international projects for malaria eradication over the next five ... contributed to research of AIDS and cancer, while malaria, ...
... Abhay Bang and Rani Bang are the two Indian Doctors ... of Heroes of Global Health in solving problems in the ... // innovated basic programs, which has reduced the infant mortality ... founders of the Maharashtra-based Society for Education, Action and Research ...
... marrow injury is an early or predisposing event in ... recent // research which appears online on September 23 ... Myelodysplastic syndrome is a heterogeneous group ... or more hematopoietic lineages, clonal evolution and a tendency ...
... transient episodes of bilateral muscle weakness with areflexia ... to narcolepsy. Cataplexy is diagnosed based on clinical ... recently but their usefulness has been limited because ... , ,Used effectively even these screening tests ...
... at Yale University have discovered the 'DCDC2' gene associated ... of children around the world. // , ,The ... 6 according to the researchers. The researchers found that ... formation of brain circuits and this genetic alteration is ...
Cached Medicine News:Health News:Bill Gates to Fund ?28m for Malaria researc 2Health News:TWO India Doctors Listed in TIME for Contribution to Global Health 2Health News:Chromosome 6 has the Dyslexia Gene 2
(Date:9/22/2014)... CHICAGO, Ill. , Sept. 22, 2014 /PRNewswire/ ... data from several clinical studies evaluating potential new ... presented at the upcoming 2014 European Society of ... Madrid, Spain . Data being ... evaluating the safety and efficacy of veliparib (ABT-888), ...
(Date:9/22/2014)... DIEGO , Sept. 22, 2014 Arena Pharmaceuticals, ... company is scheduled to present a corporate overview and ... on Friday, September 26, 2014, at 11:30 a.m. Eastern ... Hotel in New York City . ... will be available under the investor relations section of ...
(Date:9/22/2014)... , September 22, 2014 ... Line Development Market by Product (Equipment, Media and Reagents), ... Engineering & Regenerative medicine, Toxicity Testing, Research, Drug ... published by MarketsandMarkets, analyzes and studies the major ... Browse 114 market data tables and 64 ...
Breaking Medicine Technology:AbbVie to Present Clinical Study Data on Potential New Oncology Medicines at the 2014 European Society of Medical Oncology Annual Meeting 2AbbVie to Present Clinical Study Data on Potential New Oncology Medicines at the 2014 European Society of Medical Oncology Annual Meeting 3AbbVie to Present Clinical Study Data on Potential New Oncology Medicines at the 2014 European Society of Medical Oncology Annual Meeting 4Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 2Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 3Cell Line Development Market Worth $3.96 Billion by 2019 2Cell Line Development Market Worth $3.96 Billion by 2019 3Cell Line Development Market Worth $3.96 Billion by 2019 4
... HOUSTON, Jan. 23, 2012  Spine Pain Management, Inc. (OTC.BB: SPIN.PK), ... pleased to update investors on recent developments.    ... The company will present and meet with investors ... The day,s event is in Las Vegas, Nevada.  The ...
... 23, 2012  VentiRx Pharmaceuticals, Inc., a biopharmaceutical company ... 8 (TLR8) agonists for the treatment of cancer, ... that VTX-2337, the Company,s lead small molecule, is ... VTX-2337 directly activates human myeloid dendritic cells (mDCs), ...
Cached Medicine Technology:Spine Pain Management, Inc. Provides Corporate Updates 2VentiRx Pharmaceuticals Publishes Preclinical Data of Novel TLR8 Agonist, VTX-2337, Supporting Its Potential as an Immunotherapeutic Approach in Cancer 2VentiRx Pharmaceuticals Publishes Preclinical Data of Novel TLR8 Agonist, VTX-2337, Supporting Its Potential as an Immunotherapeutic Approach in Cancer 3
High resolution, multi-frequency, HST version of the UST-987-7.5. Provides even greater image detail, better resolution, and penetration....
A rigid version of the popular flexible laparoscopic transducer. It has been proven that a rigid "lap transducer has great utility in the OR for being an extra lifting tool inside the abdomen....
This is a 3D transducer for endovaginal imaging in OB/GYN....
Super High Density, 120 field of view, angled handle, multi-frequency, convex endovaginal transducer....
Medicine Products: