Navigation Links
Scripps research scientists find new genetic mutation that halts the development of lupus
Date:1/17/2008

ole in lupus susceptibility.

The study suggests genetic-mapping studies need to adequately distinguish between predisposing or suppressive alleles or alternate gene forms, and that other lupus-related loci might also be associated with suppressive alleles. In addition to traditional predisposing genes, disease-suppressing genes and spontaneous mutations, as in the case for CoroLmb3, are likely to be important contributors to an entire repertoire of genetic variations that could help alter the onset and severity of the disease in lupus patients.

Obviously, these types of variations will further complicate the identification of susceptibility genes, Kono added. However, as in the case of disease-suppressing genes such as we found in our study, their identification can provide important clues to pathogenesis and possibly therapy.

Pointing to New Possibilities

The Scripps Research scientists found the mutation on a single genetic locus-the position of a gene on a chromosome-called Lmb3 that plays a major role in modulating autoimmunity in transgenic mice. The cloned version of the Lmb3 mutation resulted in developmental and functional alterations in T cells, including reduced migration, survival, and activation. The study also showed that the Lmb3 autoimmune-suppressing phenotype could be transmitted only through Coro1aLmb3 T cells.

The fact that its action appears to be somewhat specific for T cells is unusual, Kono said. Because we were able to show that blocking CoroLmb3 has specific effects, this work suggests other cytoskeleton proteins might prove to be good targets. This opens up an area that hasnt really been considered, and gives more impetus to study these genes for autoimmunity.

Because the actin cytoskeleton is essential for many crucial cellular functions and involves complex regulatory mechanisms in specific cell types, these new findings highlight the importance of actin regulation in lupus pa
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps research scientists discover chemical triggers for aggression in mice
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps Research scientists shed new light on how antibodies fight HIV
4. Researcher, magnet lab receive $2 million grant to target tuberculosis
5. Equity Research Firm Issued Unauthorized Report and Press Release on Immunosyn Corporation Today
6. UNC, Duke lead first statewide shaken baby prevention research project in US
7. Researchers Hone in on Cancer Stem Cells for Melanoma
8. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
9. Bisexuality not a transitional phase among women, according to new research
10. Childrens Hospital Boston Mourns the Death of Dr. Judah Folkman, World Renowned Researcher and Founder of the Field of Angiogenesis
11. American Academy of Ophthalmology Mourns Loss of Judah Folkman, MD, Pioneering Researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of ... the HOPE Movement of EvolvHealth. In what has been a long-term relationship between the ... their missions of purpose together to change the course of the network marketing industry. ...
(Date:8/1/2015)... ... August 01, 2015 , ... “ reTXT ” was featured on NewsWatch ... coolest applications on the market for iOS, Android, and Windows. Joe Toohey, the host ... users to clarify, edit and delete any message including ones already sent. , While ...
(Date:7/31/2015)... ... August 01, 2015 , ... The Honor Society of Nursing, Sigma ... the Future of Nursing (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key ... meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... its new store run by GoodThreads. The store can be accessed by visiting ... designs, many of which are customizable. The best part: whenever a product is ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... communicate. Rally Insurance Group, Inc. has re-branded their social media profiles to better ... personal way for consumers to communicate, find information, share insights and opinions. The ...
Breaking Medicine News(10 mins):Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2
... Towards the Electronic,Patient Record (TEPR) -- ... today its next-generation interface terminology delivery service.,The ... to all of,IMO,s terminology knowledge sources. The ... for millisecond response times in a highly,scalable ...
... The Natural Marketing,Institute,s (NMI) Health & Wellness ... to suffer from digestive disorders than men. No ... hormones, stress, diet, or all,three., Preliminary research ... gastrointestinal problems. The studies show transit time,slows significantly ...
... Doctors and Women, WASHINGTON, May 19 A new ... less likely than,men to be treated with medications to prevent ... for women with heart,disease -- is calling on doctors to ... care that they need., "This study should serve as ...
... studies in 15 Finnish families have shown that ... aptitude. Musical aptitude was determined using three tests: ... test), and the Seashore pitch and time discrimination ... genetic study that aims in the identification of ...
... Fund has announced the 2008 recipients of the Career Awards ... Medical Scientists program is the result of the reformulation of ... by BWF in 1995 and ran through the 2006 award ... Independence program, which was modeled after the CABS award, BWF ...
... New Delhi and Singapore (May 14, 2008) ... announced its continued expansion in medical publishing with ... & Vascular Disease and Journal of the Renin-Angiotensin-Aldosterone ... British Journal of Diabetes & Vascular Disease (BJDVD) ...
Cached Medicine News:Health News:Intelligent Medical Objects (IMO), Inc. announces the General Availability of Its Terminology Portal Service for EMR/EHR and Charge-Capture Applications 2Health News:Intelligent Medical Objects (IMO), Inc. announces the General Availability of Its Terminology Portal Service for EMR/EHR and Charge-Capture Applications 3Health News:Intelligent Medical Objects (IMO), Inc. announces the General Availability of Its Terminology Portal Service for EMR/EHR and Charge-Capture Applications 4Health News:Women's Health Crisis: GI Problems Common in Women 2Health News:Study: Doctors Significantly Less Likely to Provide Women with Treatments to Prevent Heart Attacks 2Health News:BWF awards $11.2 million to support physician-scientists 2Health News:BWF awards $11.2 million to support physician-scientists 3Health News:SAGE acquires 2 new medical journals 2
(Date:7/30/2015)... CHENGDU, China , July 30, 2015 ... "Company"), a pharmaceutical company that specializes in the patented ... active pharmaceutical ingredients (API), provided updates regarding the notice ... MKT LLC (the "Exchange") indicating that the Company was ... set forth in Sections 134 and 1101 of the ...
(Date:7/30/2015)... N.J. , July 30, 2015 Eisai ... in the United States , European ... FDA, EMA and MHLW, respectively) for eribulin, for the ... who have received prior chemotherapy for advanced or metastatic ... on data from a pivotal global Phase 3 clinical ...
(Date:7/30/2015)... 2015 Future Market Insights (FMI) ... Glucose Monitoring Systems Market: Global Industry Analysis and Opportunity ... global continuous glucose monitoring systems market was valued at ... reach US$ 788.4 Mn by 2020, registering a CAGR ... Global continuous glucose monitoring systems market is ...
Breaking Medicine Technology:TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 2Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 3Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 4Eisai Submits Simultaneous Regulatory Applications for Eribulin in Soft Tissue Sarcoma in the United States, European Union and Japan 5Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
... AcelRx Pharmaceuticals, Inc. announced today that it has filed ... and Exchange Commission (SEC) relating to a proposed initial public ... the common stock to be sold in the offering will ... Co. is acting as sole book-running manager. Canaccord Genuity Inc., ...
... Nov. 12, 2010 WebMD Health Corp. (Nasdaq: ... will deliver a presentation at the Citi 7th Annual U.S. ... p.m. ET and Anthony Vuolo, COO and CFO, will join ... analysts and the general public are invited to listen to ...
Cached Medicine Technology:
... Cement consists of a two ... bone cement liquid within a ... polyethylene bag,containing bone cement powder ... interiors of the blister pack,and ...
A low viscosity type of bone cement, intended for syringe or cement gun application....
A "doughy" type of bone cement intended for manual application....
High viscosity bone cement without antibiotics for digital use with an average setting time of approx. 6-8 Min., 40g of powder and 14.4g of liquid....
Medicine Products: