Navigation Links
Scripps research scientists find new genetic mutation that halts the development of lupus
Date:1/17/2008

The new study was published in the January 18 edition (Volume 28, Issue 1) of the journal Immunity.

The lupus-suppressing action is the result of what is known as a nonsense mutation of the Coronin-1A gene (Coro1a) required for the development of the disease. A nonsense mutation causes the gene to produce proteins that no longer function. The Coronin-1A gene is a multifunctional regulator of the cytoskeleton, a network of protein fibers or filaments in the cell that helps maintain cell shape and is the key contributor to cell movement.

The mutation reduced symptoms of the disease by interfering with the development and activation of T cells and other immune responses, said Dwight Kono, an associate professor at The Scripps Research Institute. These findings solidify the critical role of Coronin-1A in normal immune responses, and identify it as a potential therapeutic target for lupus.

Two Sides of Lupus Genetics

Systemic lupus erythematosus is a serious autoimmune disease that affects approximately 1.5 million Americans. It is influenced by genetic, environmental, and hormonal factors, although genetic predisposition appears to be the single greatest contributor to its onset.

There has been considerable interest in defining the genetics of systemic lupus erythematosus in recent years, not only for gaining a better understanding of the fundamental causes of the disease but also for the development of potential therapies.

We were searching for a lupus susceptibility gene, Kono said. After mapping and cloning the Coronin-1A gene, we discovered this spontaneous mutation in a single strain of mice-those that dont get severe or systemic lupus-like disease. More than likely, the mutation had existed undetected in our mouse colony for years.

We ended up cloning a disease-resistance gene when we were thinking about doing the opposite, he continued. Suppressive genes may, in fact, play an important r
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scripps research scientists discover chemical triggers for aggression in mice
2. Scripps Health Treats More Than 160 Fire Victims at Emergency Departments Across San Diego County
3. Scripps Research scientists shed new light on how antibodies fight HIV
4. Researcher, magnet lab receive $2 million grant to target tuberculosis
5. Equity Research Firm Issued Unauthorized Report and Press Release on Immunosyn Corporation Today
6. UNC, Duke lead first statewide shaken baby prevention research project in US
7. Researchers Hone in on Cancer Stem Cells for Melanoma
8. New Research Shows Nutrition Programs Targeting Pregnancy and First 24 Months of Life Dramatically Improve Child Survival and Overall Health
9. Bisexuality not a transitional phase among women, according to new research
10. Childrens Hospital Boston Mourns the Death of Dr. Judah Folkman, World Renowned Researcher and Founder of the Field of Angiogenesis
11. American Academy of Ophthalmology Mourns Loss of Judah Folkman, MD, Pioneering Researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... AZ (PRWEB) March 28, 2015 Coffee could ... also help protect you from gum disease, researchers have found. ... against gum disease. , Coffee contains antioxidants. Antioxidants fight gum ... the question researchers at Boston Univ. Henry M. Goldman School ... in the August 2014 issue of the Journal of Periodontology. ...
(Date:3/28/2015)... March 28, 2015 Could genetic code ... new study by researchers at the Harvard ... with the support of the Coffee and Caffeine Genetics ... Psychiatry this past fall, the study—one of several recent ... genomic data from more than 120,000 regular coffee drinkers ...
(Date:3/28/2015)... "Necrorun" was featured on NewsWatch as part ... the latest and coolest applications on the market for ... NewsWatch and technology expert, conducted the app review and ... runner game with knights, nature, and peasants. , ... according to Eurogamer. The popularity of these games grew ...
(Date:3/28/2015)... Take a bite of warm, gooey pepperoni ... tumble into the stomach, ready to break down your ... these acids run amok, triggering a burning sensation in ... than 60 million Americans have heartburn at least once ... and how it can be stopped. , Heartburn or ...
(Date:3/28/2015)... 28, 2015 With more than ... fields of osteoporosis, osteoarthritis and musculoskeletal diseases gathered ... may be the first time in the 17-year ... that the hot-button topic is an emerging non-pharmaceutical ... well-accepted scientific principles of Wolff’s law, osteogenic loading ...
Breaking Medicine News(10 mins):Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2Health News:Non-Drug Protocol for Building Bone Density Expected to Steal Spotlight at World Congress on Osteoporosis 2
... BeneChill, Inc. ( www.benechill.com ) today announced the ... study. This randomized study will determine whether intra-nasal ... patient resuscitation and survival rates.The PRINCE study is ... Europe. The company received CE marking for the ...
... manufacturer of,GUM(R) and Butler(R) brand products and a leader ... worldwide, is putting its support,behind the American Dental Association,s ... health. , Each February since ... to raise awareness about the importance of oral health. ...
... most symptoms fade within 6 weeks, experts say , , ... physical therapy and anti-inflammatory drugs is the most effective ... degenerative disc disease, according to a review of published ... 90 percent of people with low back pain, symptoms ...
... part in regular physical activity have a better quality ... issue of the journal Cancer Epidemiology Biomarkers and ... more physically active report better mood, more vigor, and ... take-home message is that early-stage lung cancer survivors may ...
... ANN ARBOR, Mich. One-fifth of women who should ... potentially lifesaving treatment, according to a new study from ... , The study looked at 396 women who were ... found that 19 percent of women who fell clearly ...
... Vitamin(R) has launched the web site for Keep ,Em ... that gives pregnant women the greatest opportunity to carry ... information and offering online community support. , ... Cookin, with one very specific goal in mind --- ...
Cached Medicine News:Health News:BeneChill Launches European Study of Intra-Arrest Cooling 2Health News:Sunstar to Support ADA's 60th Annual National Children's Dental Health Month 2Health News:Sunstar to Support ADA's 60th Annual National Children's Dental Health Month 3Health News:Therapy, Meds Best for Lumbar Low Back Pain 2Health News:Regular physical activity linked to better quality of life in early-stage lung cancer survivors 2Health News:19 percent of breast cancer patients don’t receive recommended radiation after mastectomy 2Health News:Vitamin Launches Online Face for Keep 'Em Cookin' 2
(Date:3/27/2015)... YORK , March 27, 2015 BioCorRx, ... Santa Ana, California is a healthcare ... for which is estimated at $22 billion in the U.S. ... the use of FDA-approved Naltrexone in a specially compounded form ... Australia and New Zealand ...
(Date:3/27/2015)... March 27, 2015 Across the global healthcare ... challenges in clinical development, market education, and regulatory compliance. ... Medical Affairs function is expected to increase in prominence ... According to research by benchmarking firm, Best ... group dedicated to Medical Affairs. Among companies in ...
(Date:3/27/2015)... 2015  The quality function within the medical device ... quality standards at every stage of the product life ... also have the challenge of balancing quality and safety ... don,t effectively balance these priorities risk funding and staffing ... and regulatory scrutiny. For the third consecutive ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
... Clinical trials in which participants are randomly assigned to different ... conducted correctly, it,s widely accepted by the research community that ... But researchers at the University of Michigan hope to ... patients by investigating the impact of a class of innovative ...
... CRY ), an implantable biological medical device ... BioGlue Surgical Adhesive has received Shonin approval from the ... use in the repair of aortic dissections. ... in Japan for use in this subset of cardiac ...
Cached Medicine Technology:U-M Receives NIH, FDA Grant To Study Adaptive Clinical Trial Design 2CryoLife Receives Japanese Regulatory Approval for BioGlue Surgical Adhesive 2CryoLife Receives Japanese Regulatory Approval for BioGlue Surgical Adhesive 3CryoLife Receives Japanese Regulatory Approval for BioGlue Surgical Adhesive 4CryoLife Receives Japanese Regulatory Approval for BioGlue Surgical Adhesive 5
Benchtop UV Incubator is designed to provide precise temperature control and uniformity throughout the chamber. Decontaminate chamber between experiments with built-in shortwave UV....
Inquire...
Inquire...
Inquire...
Medicine Products: